Outcome after high-dose chemotherapy and autologous stem cell transplantation in patients with aggressive B-cell non-Hodgkin's lymphoma
Objective For more than two decades, high-dose chemotherapy (HDT) and autologous blood stem cell transplantation (ABSCT) were treatment options for patients with aggressive B-cell non-Hodgkin's lymphoma (B-NHL). However, the ideal timing and the collective patient benefits are still being debat...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
25 March 2018
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| In: |
European journal of haematology
Year: 2018, Volume: 101, Issue: 1, Pages: 12-20 |
| ISSN: | 1600-0609 |
| DOI: | 10.1111/ejh.13064 |
| Online Access: | Verlag, Volltext: https://doi.org/10.1111/ejh.13064 Verlag: https://onlinelibrary.wiley.com/doi/abs/10.1111/ejh.13064 
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| Author Notes: | Katharina Kriegsmann, Michael Rieger, Mark-Alexander Schwarzbich, Sören Sitter, Mark Kriegsmann, Thomas Bruckner, Manfred Hensel, Anthony Dick Ho, Mathias Witzens‐Harig, Patrick Wuchter |
MARC
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| 245 | 1 | 0 | |a Outcome after high-dose chemotherapy and autologous stem cell transplantation in patients with aggressive B-cell non-Hodgkin's lymphoma |c Katharina Kriegsmann, Michael Rieger, Mark-Alexander Schwarzbich, Sören Sitter, Mark Kriegsmann, Thomas Bruckner, Manfred Hensel, Anthony Dick Ho, Mathias Witzens‐Harig, Patrick Wuchter |
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| 520 | |a Objective For more than two decades, high-dose chemotherapy (HDT) and autologous blood stem cell transplantation (ABSCT) were treatment options for patients with aggressive B-cell non-Hodgkin's lymphoma (B-NHL). However, the ideal timing and the collective patient benefits are still being debated. Method We retrospectively analyzed the data of 163 patients with B-NHL who received an HDT protocol followed by ABSCT between 2001 and 2007. Patients were analyzed according to the time point of HDT/ABSCT to compare upfront (directly after induction, n = 72, 44%) versus secondary transplantation (at first relapse, n = 91, 56%). Results The overall response rate was 100% and 94% after upfront and secondary HDT/ABSCT, respectively. No significant differences were found for hematopoietic recovery and toxicity profile. The progression-free survival (PFS) and overall survival (OS) probability were found to be significantly higher in the upfront HDT/ABSCT treatment group (P = .018 and P = .004). In multivariate analysis, upfront HDT/ABSCT and low IPI risk score had a significant beneficial effect on OS (P = .031 and P = .019). Conclusion HDT and ABSCT directly after induction chemotherapy were confirmed to be feasible with high PFS and OS rates. In addition, for patients with relapse after first-line therapy and consecutively poor prognosis, HDT/ABSCT also offers an effective treatment strategy. | ||
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