Autologous stem cell transplantation for HIV-associated lymphoma in the antiretroviral and rituximab era: a retrospective study by the EBMT Lymphoma Working Party
The present study aimed at describing the outcome of patients with HIV-associated lymphomas following autologous hematopoietic stem cell transplantation (autoHCT) in the rituximab and combined antiretroviral therapy (cART) era. Eligible for this retrospective study were HIV-positive patients with ly...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
25 February 2019
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| In: |
Bone marrow transplantation
Year: 2019, Volume: 54, Issue: 10, Pages: 1625-1631 |
| ISSN: | 1476-5365 |
| DOI: | 10.1038/s41409-019-0480-x |
| Online Access: | Verlag, Volltext: https://doi.org/10.1038/s41409-019-0480-x Verlag: https://www.nature.com/articles/s41409-019-0480-x 
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| Author Notes: | Kai Hübel, Alessandro Re, Ariane Boumendil, Herve Finel, Marcus Hentrich, Stephen Robinson, Christoph Wyen, Mariagrazia Michieli, Edward Kanfer, Jose Luis Diez-Martin, Pascual Balsalobre, Laure Vincent, Wilfried Schroyens, Josep Maria Ribera Santasusana, Nicolaus Kröger, Xaver Schiel, Kate Cwynarski, Albert Esquirol, Aida Botelho Sousa, Chiara Cattaneo, Silvia Montoto, Peter Dreger |
| Summary: | The present study aimed at describing the outcome of patients with HIV-associated lymphomas following autologous hematopoietic stem cell transplantation (autoHCT) in the rituximab and combined antiretroviral therapy (cART) era. Eligible for this retrospective study were HIV-positive patients with lymphoma who received autoHCT between 2007 and 2013. A total of 118 patients were included with a median age of 45 years (range 24-66). Underlying diagnoses were diffuse large B cell lymphoma in 47%, Hodgkin lymphoma in 24%, Burkitt lymphoma in 18%, and plasmablastic lymphoma in 7% of patients. Disease status at autoHCT was complete remission in 44%, partial remission (PR) in 38%, and less than PR in 18% of the patients. With a median follow-up of 4 years, 3-year non-relapse mortality, incidence of relapse, progression-free survival (PFS) and overall survival (OS) were 10%, 27%, 63% and 66%, respectively. By multivariate analysis, disease status less than PR but not CD4+ cell count at the time of autoHCT was a significant predictor of unfavorable PFS and OS. In conclusion, in the era of cART and chemoimmunotherapy, the outcome of autoHCT for HIV-related lymphoma is driven by lymphoma-dependent risk factors rather than by characteristics of the HIV infection. |
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| Item Description: | Gesehen am 29.10.2019 |
| Physical Description: | Online Resource |
| ISSN: | 1476-5365 |
| DOI: | 10.1038/s41409-019-0480-x |