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Normalization of tumor vessels by Tie2 activation and Ang2 inhibition enhances drug delivery and produces a favorable tumor microenvironment

A destabilized tumor vasculature leads to limited drug delivery, hypoxia, detrimental tumor microenvironment, and even metastasis. We performed a side-by-side comparison of ABTAA (Ang2-Binding and Tie2-Activating Antibody) and ABA (Ang2-Blocking Antibody) in mice with orthotopically implanted glioma...

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Hauptverfasser: Park, Jin-Sung (VerfasserIn) , Augustin, Hellmut (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: December 12, 2016
In: Cancer cell
Year: 2016, Jahrgang: 30, Heft: 6, Pages: 953-967
ISSN:1878-3686
DOI:10.1016/j.ccell.2016.10.018
Online-Zugang:Verlag, Volltext: https://doi.org/10.1016/j.ccell.2016.10.018
Verlag: http://www.sciencedirect.com/science/article/pii/S1535610816305050
Volltext
Verfasserangaben:Jin-Sung Park, Il-Kug Kim, Sangyeul Han, Intae Park, Chan Kim, Jeomil Bae, Seung Ja Oh, Seungjoo Lee, Jeong Hoon Kim, Dong-Cheol Woo, Yulong He, Hellmut G. Augustin, Injune Kim, Doheon Lee, and Gou Young Koh
Beschreibung
Zusammenfassung:A destabilized tumor vasculature leads to limited drug delivery, hypoxia, detrimental tumor microenvironment, and even metastasis. We performed a side-by-side comparison of ABTAA (Ang2-Binding and Tie2-Activating Antibody) and ABA (Ang2-Blocking Antibody) in mice with orthotopically implanted glioma, with subcutaneously implanted Lewis lung carcinoma, and with spontaneous mammary cancer. We found that Tie2 activation induced tumor vascular normalization, leading to enhanced blood perfusion and chemotherapeutic drug delivery, markedly lessened lactate acidosis, and reduced tumor growth and metastasis. Moreover, ABTAA favorably altered the immune cell profile within tumors. Together, our findings establish that simultaneous Tie2 activation and Ang2 inhibition form a powerful therapeutic strategy to elicit a favorable tumor microenvironment and enhanced delivery of a chemotherapeutic agent into tumors.
Beschreibung:Gesehen am 31.10.2019
Beschreibung:Online Resource
ISSN:1878-3686
DOI:10.1016/j.ccell.2016.10.018

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