Multiple prevalent fractures in relation to macroscopic bone architecture in patients with cystic fibrosis
Background - The relative risk for bone fractures in patients with cystic fibrosis (CF) and its relationship to macroscopic bone architecture assessed by pQCT and DXA are incompletely defined. - Methods - In a cross-sectional study of 43 CF patients (age, 17.8±6.2years), rate and location of fractur...
Gespeichert in:
| Hauptverfasser: | , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
[January 2018]
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| In: |
Journal of cystic fibrosis
Year: 2018, Jahrgang: 17, Heft: 1, Pages: 114-120 |
| ISSN: | 1873-5010 |
| DOI: | 10.1016/j.jcf.2016.06.004 |
| Online-Zugang: | Verlag, Volltext: https://doi.org/10.1016/j.jcf.2016.06.004 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S1569199316305471 
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| Verfasserangaben: | Mirjam Stahl, Christian Holfelder, Carolin Kneppo, Meinhard Kieser, Christian Kasperk, Eckhard Schoenau, Olaf Sommerburg, Burkhard Tönshoff |
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| 245 | 1 | 0 | |a Multiple prevalent fractures in relation to macroscopic bone architecture in patients with cystic fibrosis |c Mirjam Stahl, Christian Holfelder, Carolin Kneppo, Meinhard Kieser, Christian Kasperk, Eckhard Schoenau, Olaf Sommerburg, Burkhard Tönshoff |
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| 520 | |a Background - The relative risk for bone fractures in patients with cystic fibrosis (CF) and its relationship to macroscopic bone architecture assessed by pQCT and DXA are incompletely defined. - Methods - In a cross-sectional study of 43 CF patients (age, 17.8±6.2years), rate and location of fractures, bone mass, density, geometry, and strength of the radius as well as forearm muscle size were investigated. - Results - The fracture rate in CF was 9.2-fold higher compared to an age-matched German control population. The probability of remaining free of any fracture in CF patients at 25years was reduced to 39.8% compared to 84.6% in controls (P<0.001). Assessment of macroscopic bone architecture by DXA and pQCT allowed the differentiation of patients with multiple prevalent fractures with a high sensitivity (up to 100%) and specificity (up to 94.3%). - Conclusions - Bone densitometry is a useful tool for noninvasive assessment of fracture risk in CF patients. | ||
| 650 | 4 | |a Bone densitometry | |
| 650 | 4 | |a Bone disease | |
| 650 | 4 | |a Cystic fibrosis | |
| 650 | 4 | |a Fracture rate | |
| 650 | 4 | |a Macroscopic bone architecture | |
| 650 | 4 | |a Noninvasive monitoring | |
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