Prognostic role of miR-221 and miR-222 expression in cancer patients: a systematic review and meta-analysis
Background: A wealth of evidence has shown that microRNAs (miRNAs) can modulate specific genes, increasing our knowledge on the fine-tuning regulation of protein expression. miR-221 and miR-222 have been frequently identified as deregulated across different cancer types; however, their prognostic si...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
11 July 2019
|
| In: |
Cancers
Year: 2019, Volume: 11, Issue: 7 |
| ISSN: | 2072-6694 |
| DOI: | 10.3390/cancers11070970 |
| Online Access: | Verlag, Volltext: https://doi.org/10.3390/cancers11070970 Verlag: https://www.mdpi.com/2072-6694/11/7/970 
|
| Author Notes: | Gloria Ravegnini, Sarah Cargnin, Giulia Sammarini, Federica Zanotti, Justo Lorenzo Bermejo, Patrizia Hrelia, Salvatore Terrazzino and Sabrina Angelini |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1680890921 | ||
| 003 | DE-627 | ||
| 005 | 20230427033330.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 191104s2019 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.3390/cancers11070970 |2 doi | |
| 035 | |a (DE-627)1680890921 | ||
| 035 | |a (DE-599)KXP1680890921 | ||
| 035 | |a (OCoLC)1341250245 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Ravegnini, Gloria |e VerfasserIn |0 (DE-588)1198718684 |0 (DE-627)1680891782 |4 aut | |
| 245 | 1 | 0 | |a Prognostic role of miR-221 and miR-222 expression in cancer patients |b a systematic review and meta-analysis |c Gloria Ravegnini, Sarah Cargnin, Giulia Sammarini, Federica Zanotti, Justo Lorenzo Bermejo, Patrizia Hrelia, Salvatore Terrazzino and Sabrina Angelini |
| 264 | 1 | |c 11 July 2019 | |
| 300 | |a 24 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 04.11.2019 | ||
| 520 | |a Background: A wealth of evidence has shown that microRNAs (miRNAs) can modulate specific genes, increasing our knowledge on the fine-tuning regulation of protein expression. miR-221 and miR-222 have been frequently identified as deregulated across different cancer types; however, their prognostic significance in cancer remains controversial. In view of these considerations, we performed an updated systematic review and meta-analysis of published data investigating the effects of miR-221/222 on overall survival (OS) and other secondary outcomes among cancer patients. A systematic search of PubMed, Web of Knowledge, and Cochrane Library databases was performed. Hazard ratios (HRs) and 95% confidence intervals (95% CIs) were used to assess the strength of association. Results: Fifty studies, analyzing 6086 patients, were included in the systematic review. Twenty-five studies for miR-221 and 17 studies for miR-222 which assessed OS were included in the meta-analysis. High expression of miR-221 and miR-222 significantly predicted poor OS (HR: 1.48, 95% CI: 1.14–1.93, p = 0.003 and HR: 1.90, 95% CI: 1.43–2.54, p < 0.001, respectively). Subgroup analysis revealed that the finding on miR-221 was not as robust as the one on miR-222. Furthermore, high miR-222 expression was also associated with worse progression-free survival and disease-free survival pooled with recurrence-free survival. Conclusions: The meta-analysis demonstrated that high expression of miR-222 is associated with poor prognosis in cancer patients, whereas the significance of miR-221 remains unclear. More work is required to fully elucidate the role of miR-221 and miR-222 in cancer prognosis, particularly in view of the limitations of existing results, including the significant heterogeneity and limited number of studies for some cancers. | ||
| 650 | 4 | |a cancer | |
| 650 | 4 | |a miR-221 | |
| 650 | 4 | |a miR-222 | |
| 650 | 4 | |a overall survival | |
| 650 | 4 | |a progression-free survival | |
| 700 | 1 | |a Lorenzo Bermejo, Justo |d 1972- |e VerfasserIn |0 (DE-588)124754619 |0 (DE-627)706705572 |0 (DE-576)294483632 |4 aut | |
| 700 | 1 | |a Hrelia, Patrizia |e VerfasserIn |4 aut | |
| 700 | 1 | |a Terrazzino, Salvatore |e VerfasserIn |4 aut | |
| 700 | 1 | |a Angelini, Sabrina |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Cancers |d Basel : MDPI, 2009 |g 11(2019,7) Artikel-Nummer 970, 24 Seiten |h Online-Ressource |w (DE-627)614095670 |w (DE-600)2527080-1 |w (DE-576)313958548 |x 2072-6694 |7 nnas |a Prognostic role of miR-221 and miR-222 expression in cancer patients a systematic review and meta-analysis |
| 773 | 1 | 8 | |g volume:11 |g year:2019 |g number:7 |g extent:24 |a Prognostic role of miR-221 and miR-222 expression in cancer patients a systematic review and meta-analysis |
| 856 | 4 | 0 | |u https://doi.org/10.3390/cancers11070970 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u https://www.mdpi.com/2072-6694/11/7/970 |x Verlag |
| 951 | |a AR | ||
| 992 | |a 20191104 | ||
| 993 | |a Article | ||
| 994 | |a 2019 | ||
| 998 | |g 124754619 |a Lorenzo Bermejo, Justo |m 124754619:Lorenzo Bermejo, Justo |d 910000 |d 999701 |e 910000PL124754619 |e 999701PL124754619 |k 0/910000/ |k 1/910000/999701/ |p 5 | ||
| 999 | |a KXP-PPN1680890921 |e 3536602495 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"person":[{"roleDisplay":"VerfasserIn","display":"Ravegnini, Gloria","role":"aut","family":"Ravegnini","given":"Gloria"},{"given":"Justo","family":"Lorenzo Bermejo","role":"aut","roleDisplay":"VerfasserIn","display":"Lorenzo Bermejo, Justo"},{"family":"Hrelia","given":"Patrizia","roleDisplay":"VerfasserIn","display":"Hrelia, Patrizia","role":"aut"},{"display":"Terrazzino, Salvatore","roleDisplay":"VerfasserIn","role":"aut","family":"Terrazzino","given":"Salvatore"},{"roleDisplay":"VerfasserIn","display":"Angelini, Sabrina","role":"aut","family":"Angelini","given":"Sabrina"}],"title":[{"title_sort":"Prognostic role of miR-221 and miR-222 expression in cancer patients","subtitle":"a systematic review and meta-analysis","title":"Prognostic role of miR-221 and miR-222 expression in cancer patients"}],"language":["eng"],"recId":"1680890921","type":{"media":"Online-Ressource","bibl":"article-journal"},"note":["Gesehen am 04.11.2019"],"name":{"displayForm":["Gloria Ravegnini, Sarah Cargnin, Giulia Sammarini, Federica Zanotti, Justo Lorenzo Bermejo, Patrizia Hrelia, Salvatore Terrazzino and Sabrina Angelini"]},"id":{"eki":["1680890921"],"doi":["10.3390/cancers11070970"]},"origin":[{"dateIssuedDisp":"11 July 2019","dateIssuedKey":"2019"}],"relHost":[{"type":{"bibl":"periodical","media":"Online-Ressource"},"note":["Gesehen am 27.05.2020"],"disp":"Prognostic role of miR-221 and miR-222 expression in cancer patients a systematic review and meta-analysisCancers","language":["eng"],"recId":"614095670","pubHistory":["1.2009 -"],"part":{"extent":"24","volume":"11","text":"11(2019,7) Artikel-Nummer 970, 24 Seiten","issue":"7","year":"2019"},"title":[{"title":"Cancers","title_sort":"Cancers"}],"physDesc":[{"extent":"Online-Ressource"}],"name":{"displayForm":["Molecular Diversity Preservation International (MDPI)"]},"origin":[{"publisher":"MDPI","dateIssuedKey":"2009","dateIssuedDisp":"2009-","publisherPlace":"Basel"}],"id":{"zdb":["2527080-1"],"eki":["614095670"],"issn":["2072-6694"]}}],"physDesc":[{"extent":"24 S."}]} | ||
| SRT | |a RAVEGNINIGPROGNOSTIC1120 | ||