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Short- and long-term incidence of thromboembolic events in Takotsubo Syndrome as compared with acute coronary syndrome

Thromboembolic events are a common complication in Takotsubo syndrome (TTS). However, their long-term incidence compared with acute coronary syndrome (ACS) is lacking. In-hospital and long-term incidence of thromboembolic events of 138 consecutive patients with TTS were compared with 138 sex- and ag...

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Main Authors: El-Battrawy, Ibrahim (Author) , Gietzen, Thorsten (Author) , Lang, Siegfried (Author) , Ansari, Uzair (Author) , Behnes, Michael (Author) , Zhou, Xiao-Bo (Author) , Borggrefe, Martin (Author) , Akın, Ibrahim (Author)
Format: Article (Journal)
Language:English
Published: April 15, 2019
In: Angiology
Year: 2019, Volume: 70, Issue: 9, Pages: 838-843
ISSN:1940-1574
DOI:10.1177/0003319719842682
Online Access:Verlag, Volltext: https://doi.org/10.1177/0003319719842682
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Author Notes:Ibrahim El-Battrawy, Thorsten Gietzen, Siegfried Lang, Uzair Ansari, Michael Behnes, Xiaobo Zhou, Martin Borggrefe, Ibrahim Akin

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520 |a Thromboembolic events are a common complication in Takotsubo syndrome (TTS). However, their long-term incidence compared with acute coronary syndrome (ACS) is lacking. In-hospital and long-term incidence of thromboembolic events of 138 consecutive patients with TTS were compared with 138 sex- and age-matched patients with ACS. Predictors of events were analyzed. The incidence of thromboembolic events in TTS was 2-fold higher than ACS (21% vs 9%; P < .01) over a mean follow-up of 5 years. Although the left ventricular ejection fraction (LVEF) at event was significantly lower in TTS compared with ACS (38% [9%] vs 54% [11%]; P < .01), the follow-up LVEF was comparable. Patients with TTS suffering from thromboembolic events were more often treated with anticoagulation compared with ACS (44.8% vs 8.3%, P = .03). However, more patients presenting with ACS (100% vs 48.3%; P < .01) were discharged on aspirin. Only elevated C-reactive protein was a predictor of thromboembolic events using multivariate analysis (hazard ratio 1.1, 95% confidence interval, 1.0-1.2; P < .01). In conclusion, the risk of thromboembolic events in TTS was significantly higher than the risk of thromboembolic events in ACS over a mean follow-up of 5 years. 
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