Fibroblast growth factor receptor 4 (FGFR4) as detected by immunohistochemistry is associated with postoperative residual disease in ovarian cancer
Purpose Fibroblast Growth Factor Receptor 4 (FGFR4) was proposed to hold prognostic significance in high-grade serous ovarian carcinoma (HGSOC). However, information on this deriving from large, representative patient panels is still missing, though such data would be indispensable to validate suit...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
5 August 2019
|
| In: |
Journal of cancer research and clinical oncology
Year: 2019, Volume: 145, Issue: 9, Pages: 2251-2259 |
| ISSN: | 1432-1335 |
| DOI: | 10.1007/s00432-019-02986-0 |
| Online Access: | Verlag, Volltext: https://doi.org/10.1007/s00432-019-02986-0 Verlag: http://link.springer.com/10.1007/s00432-019-02986-0 
|
| Author Notes: | Sabine Heublein, Michael S. Anglesio, Frederik Marmé, Stefan Kommoss |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1681421615 | ||
| 003 | DE-627 | ||
| 005 | 20220817021254.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 191107s2019 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s00432-019-02986-0 |2 doi | |
| 035 | |a (DE-627)1681421615 | ||
| 035 | |a (DE-599)KXP1681421615 | ||
| 035 | |a (OCoLC)1341250536 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Heublein, Sabine |e VerfasserIn |0 (DE-588)1109920091 |0 (DE-627)864502745 |0 (DE-576)475662733 |4 aut | |
| 245 | 1 | 0 | |a Fibroblast growth factor receptor 4 (FGFR4) as detected by immunohistochemistry is associated with postoperative residual disease in ovarian cancer |c Sabine Heublein, Michael S. Anglesio, Frederik Marmé, Stefan Kommoss |
| 264 | 1 | |c 5 August 2019 | |
| 300 | |a 9 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 07.11.2019 | ||
| 520 | |a Purpose Fibroblast Growth Factor Receptor 4 (FGFR4) was proposed to hold prognostic significance in high-grade serous ovarian carcinoma (HGSOC). However, information on this deriving from large, representative patient panels is still missing, though such data would be indispensable to validate suitability of FGFR4 as prognostic marker or even pharmacological target. - Methods 1063 ovarian cancer cases were included in this study. Immunohistochemistry (IHC) was performed using two different anti-FGFR4 specific antibodies (HPA027273, sc-124) on an automated staining system. IHC data of both FGFR4 antibodies were available from 995 cases. FGFR4 immunostaining was correlated to prognostic factors including survival using uni- and multivariate proportional hazard models. - Results FGFR4 was positively associated with advanced FIGO stage, high grade and presence of residual disease. When progression free (PFS) of FGFR4 negative vs. positive patients was compared, patients scored as FGFR4 positive had significantly shortened PFS as compared to those that stained negative. All associations of FGFR4 and shortened PFS were lost during multivariate testing. No significant associations were found in terms of OS. - Conclusions We were not able to confirm FGFR4 as an independent negative prognosticator as described before. However, FGFR4 was highly prevalent in those cases harboring residual disease after debulking surgery. Since especially patients that could only be debulked sub-optimally may benefit from targeted adjuvant treatment, tyrosine kinase inhibitors targeting FGFRs might turn out to be an interesting future treatment option. | ||
| 700 | 1 | |a Marmé, Frederik |d 1974- |e VerfasserIn |0 (DE-588)132561972 |0 (DE-627)52394893X |0 (DE-576)299226549 |4 aut | |
| 700 | 1 | |a Kommoss, Stefan |d 1978- |e VerfasserIn |0 (DE-588)13261555X |0 (DE-627)690728115 |0 (DE-576)299258467 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of cancer research and clinical oncology |d Berlin : Springer, 1979 |g 145(2019), 9, Seite 2251-2259 |h Online-Ressource |w (DE-627)253769515 |w (DE-600)1459285-X |w (DE-576)072578319 |x 1432-1335 |7 nnas |a Fibroblast growth factor receptor 4 (FGFR4) as detected by immunohistochemistry is associated with postoperative residual disease in ovarian cancer |
| 773 | 1 | 8 | |g volume:145 |g year:2019 |g number:9 |g pages:2251-2259 |g extent:9 |a Fibroblast growth factor receptor 4 (FGFR4) as detected by immunohistochemistry is associated with postoperative residual disease in ovarian cancer |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00432-019-02986-0 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u http://link.springer.com/10.1007/s00432-019-02986-0 |x Verlag |
| 951 | |a AR | ||
| 992 | |a 20191107 | ||
| 993 | |a Article | ||
| 994 | |a 2019 | ||
| 998 | |g 132561972 |a Marmé, Frederik |m 132561972:Marmé, Frederik |d 910000 |d 910400 |d 60000 |d 61300 |d 50000 |e 910000PM132561972 |e 910400PM132561972 |e 60000PM132561972 |e 61300PM132561972 |e 50000PM132561972 |k 0/910000/ |k 1/910000/910400/ |k 0/60000/ |k 1/60000/61300/ |k 0/50000/ |p 3 | ||
| 998 | |g 1109920091 |a Heublein, Sabine |m 1109920091:Heublein, Sabine |d 910000 |d 910400 |e 910000PH1109920091 |e 910400PH1109920091 |k 0/910000/ |k 1/910000/910400/ |p 1 |x j | ||
| 999 | |a KXP-PPN1681421615 |e 3538380643 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"type":{"media":"Online-Ressource","bibl":"article-journal"},"id":{"doi":["10.1007/s00432-019-02986-0"],"eki":["1681421615"]},"physDesc":[{"extent":"9 S."}],"relHost":[{"note":["Gesehen am 19.03.25","Teils ungezählte Beil.: Supplement"],"physDesc":[{"extent":"Online-Ressource"}],"id":{"eki":["253769515"],"issn":["1432-1335"],"zdb":["1459285-X"]},"part":{"issue":"9","extent":"9","pages":"2251-2259","year":"2019","text":"145(2019), 9, Seite 2251-2259","volume":"145"},"title":[{"title_sort":"Journal of cancer research and clinical oncology","subtitle":"official organ of the Deutsche Krebsgesellschaft","title":"Journal of cancer research and clinical oncology"}],"origin":[{"publisher":"Springer","dateIssuedDisp":"1979-","dateIssuedKey":"1979","publisherPlace":"Berlin ; Heidelberg"}],"pubHistory":["Volume 93, issue 1 (January 1979)-"],"type":{"media":"Online-Ressource","bibl":"periodical"},"language":["eng","ger"],"titleAlt":[{"title":"Cancer research and clinical oncology"}],"recId":"253769515","disp":"Fibroblast growth factor receptor 4 (FGFR4) as detected by immunohistochemistry is associated with postoperative residual disease in ovarian cancerJournal of cancer research and clinical oncology"}],"note":["Gesehen am 07.11.2019"],"recId":"1681421615","name":{"displayForm":["Sabine Heublein, Michael S. Anglesio, Frederik Marmé, Stefan Kommoss"]},"origin":[{"dateIssuedDisp":"5 August 2019","dateIssuedKey":"2019"}],"person":[{"display":"Heublein, Sabine","given":"Sabine","family":"Heublein","role":"aut"},{"family":"Marmé","display":"Marmé, Frederik","given":"Frederik","role":"aut"},{"role":"aut","display":"Kommoss, Stefan","given":"Stefan","family":"Kommoss"}],"language":["eng"],"title":[{"title":"Fibroblast growth factor receptor 4 (FGFR4) as detected by immunohistochemistry is associated with postoperative residual disease in ovarian cancer","title_sort":"Fibroblast growth factor receptor 4 (FGFR4) as detected by immunohistochemistry is associated with postoperative residual disease in ovarian cancer"}]} | ||
| SRT | |a HEUBLEINSAFIBROBLAST5201 | ||