Distal pancreatectomy with celiac axis resection (DP-CAR) for pancreatic cancer: how I do it

Approximately 30% of all pancreatic cancer patients have locally advanced (AJCC stage 3) disease. A sub-group of these patients - where the cancer only involves the celiac axis - may benefit from distal pancreatectomy with celiac axis resection (DP-CAR). Previous studies have shown that DP-CAR offer...

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Hauptverfasser: Klompmaker, Sjors (VerfasserIn) , Hackert, Thilo (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 13 August 2018
In: Journal of gastrointestinal surgery
Year: 2018, Jahrgang: 22, Heft: 10, Pages: 1804-1810
ISSN:1873-4626
DOI:10.1007/s11605-018-3894-7
Online-Zugang:Resolving-System, Volltext: https://doi.org/10.1007/s11605-018-3894-7
Verlag: https://link.springer.com/article/10.1007%2Fs11605-018-3894-7
Volltext
Verfasserangaben:Sjors Klompmaker, Ugo Boggi, Thilo Hackert, Roberto Salvia, Matthew Weiss, Hiroki Yamaue, Herbert J. Zeh, Marc G. Besselink

MARC

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520 |a Approximately 30% of all pancreatic cancer patients have locally advanced (AJCC stage 3) disease. A sub-group of these patients - where the cancer only involves the celiac axis - may benefit from distal pancreatectomy with celiac axis resection (DP-CAR). Previous studies have shown that DP-CAR offers a survival benefit to a selected group of patients with otherwise unresectable pancreatic cancer, when performed by experienced pancreatic cancer treatment teams at high-volume centers. This article proposes a standardized approach to DP-CAR, including routine neoadjuvant (FOLFIRINOX) chemotherapy. This approach to selecting patients and performing DP-CAR has the potential to improve short-term outcomes and overall survival in selected patients, but it should be reserved for high-volume centers. 
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