The ColoCare study: a paradigm of transdisciplinary science in colorectal cancer outcomes
Background: Colorectal cancer is a leading cause of cancer death. Biomarkers to predict treatment outcomes are needed, as is evidence whether postdiagnosis diet and lifestyle can affect well-being and clinical outcomes. The international ColoCare Consortium aims to identify new biologic markers (e.g...
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| Hauptverfasser: | , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2019
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| In: |
Cancer epidemiology, biomarkers & prevention
Year: 2018, Jahrgang: 28, Heft: 3, Pages: 591-601 |
| ISSN: | 1538-7755 |
| DOI: | 10.1158/1055-9965.EPI-18-0773 |
| Online-Zugang: | Verlag, Volltext: https://doi.org/10.1158/1055-9965.EPI-18-0773 Verlag, Volltext: https://cebp.aacrjournals.org/content/28/3/591 
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| Verfasserangaben: | Cornelia M. Ulrich, Biljana Gigic, Jürgen Böhm, Jennifer Ose, Richard Viskochil, Martin Schneider, Graham A. Colditz, Jane C. Figueiredo, William M. Grady, Christopher I. Li, David Shibata, Erin M. Siegel, Adetunji T. Toriola, and Alexis Ulrich |
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| 245 | 1 | 4 | |a The ColoCare study |b a paradigm of transdisciplinary science in colorectal cancer outcomes |c Cornelia M. Ulrich, Biljana Gigic, Jürgen Böhm, Jennifer Ose, Richard Viskochil, Martin Schneider, Graham A. Colditz, Jane C. Figueiredo, William M. Grady, Christopher I. Li, David Shibata, Erin M. Siegel, Adetunji T. Toriola, and Alexis Ulrich |
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| 520 | |a Background: Colorectal cancer is a leading cause of cancer death. Biomarkers to predict treatment outcomes are needed, as is evidence whether postdiagnosis diet and lifestyle can affect well-being and clinical outcomes. The international ColoCare Consortium aims to identify new biologic markers (e.g., metabolomic, transcriptomic, metagenomic, genetic, epigenetic, proteomic markers) that predict clinical outcomes, and to characterize associations between modifiable risk factors (e.g., diet, supplement use, physical activity) with short-term and long-term patient-reported and clinical outcomes among patients with colorectal cancer.Methods/Results: ColoCare is recruiting newly diagnosed patients with colorectal cancer across six sites in the United States and one site in Germany. As of April 2018, we have recruited >2,000 patients across all sites. Our projected enrollment is >4,000 multiethnic patients with colorectal cancer. The study includes uniformly collected, comprehensive sets of data and biospecimens at multiple time points up to 5 years after diagnosis. Treatment and clinical data are abstracted from medical records and centrally harmonized. Biospecimens are archived according to standardized procedures. Our initial studies demonstrated metabolic differences in adipose tissue types. We further reported on associations of biological factors (e.g., inflammation, DNA methylation, metabolomics) with lifestyle factors (e.g., adiposity, smoking, physical activity, dietary supplement use) or joint associations with clinical outcomes. - Conclusions: ColoCare is a consortium for the investigation of multilevel factors relevant to colorectal cancer survivorship. - Impact: The combination of a comprehensive set of biospecimens collected at multiple time points, jointly with detailed assessments of health behaviors and other prognostic factors, results in a unique resource that facilitates wide-ranging, innovative, and impactful research on colorectal cancer. | ||
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