Impact of interventions and tumor stage on health-related quality of life in patients with hepatocellular carcinoma
Purpose: This study aims to examine the health-related quality of life in patients with hepatocellular carcinoma. Methods: 181 patients attending a tertiary center outpatient clinic were interviewed and completed the short form 36 (SF36) questionnaire. The SF36 was used to assess health-related QoL....
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| Hauptverfasser: | , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
19 August 2019
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| In: |
Journal of cancer research and clinical oncology
Year: 2019, Jahrgang: 145, Heft: 11, Pages: 2761-2769 |
| ISSN: | 1432-1335 |
| DOI: | 10.1007/s00432-019-03005-y |
| Online-Zugang: | Verlag, Volltext: https://doi.org/10.1007/s00432-019-03005-y
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| Verfasserangaben: | Cyrill Wehling, Daniel Hornuss, Pasquale Schneider, Christoph Springfeld, Katrin Hoffmann, De-Hua Chang, Patrick Naumann, Markus Mieth, Thomas Longerich, Clemens Kratochwil, Arianeb Mehrabi, Annika Gauss, Karl Heinz Weiss, Jan Pfeiffenberger |
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| 245 | 1 | 0 | |a Impact of interventions and tumor stage on health-related quality of life in patients with hepatocellular carcinoma |c Cyrill Wehling, Daniel Hornuss, Pasquale Schneider, Christoph Springfeld, Katrin Hoffmann, De-Hua Chang, Patrick Naumann, Markus Mieth, Thomas Longerich, Clemens Kratochwil, Arianeb Mehrabi, Annika Gauss, Karl Heinz Weiss, Jan Pfeiffenberger |
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| 520 | |a Purpose: This study aims to examine the health-related quality of life in patients with hepatocellular carcinoma. Methods: 181 patients attending a tertiary center outpatient clinic were interviewed and completed the short form 36 (SF36) questionnaire. The SF36 was used to assess health-related QoL. Cross-sectional analyses by group (age, gender, clinical scores, systemic, and local interventions) as well sequel questionnaires were conducted. Results: Participants included were 79% (143/181) men [mean age at first SF36: 63.8 (± 12.3; 18.4-85.8) years]. Barcelona Clinic Liver Cancer (BCLC) stadium C was associated with significantly lower SF36 total scores, and elevated initial alpha-fetoprotein (AFP) concentrations were associated with lower SF36 functional and mental health sum scores throughout the course of the third questionnaire. Patients treated with sorafenib had within the sub-dimension scores a significantly lower result for role limitations due to physical health compared to patients without sorafenib treatment. Patients who underwent a transarterial chemoembolization (TACE) had within the sub-dimension scores a significantly higher result for control of pain compared to patients without TACE. Kaplan-Meier analysis revealed significant survival benefits for patients who underwent any intervention at the first SF36 (mean survival in years 4.3 vs. 1.6; P < 0.01) as well as for patients who underwent hepatic resection (mean survival in years 6.3 vs. 2.7; P < 0.0001). Conclusion: Advanced tumor stages marked by BCLC stadium C and elevated initial AFP concentrations were associated with lower SF36 total scores and functional sum scores, respectively. During the course of sorafenib treatment, the sub-dimensional score for role limitations due to physical health decreased significantly, whereas TACE performance was associated with a significant improvement of the control of body pain. | ||
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