Clinical benefits of systemic amoxicillin/metronidazole may depend on periodontitis severity and patients' age: an exploratory sub-analysis of the ABPARO trial
Aim The aim was to identify benefit thresholds for clinical variables. We hypothesize, if variables fall below or exceed these threshold levels, systemic amoxicillin/metronidazole may contribute to reducing progression of periodontitis. Material & Methods This is an explorative per-protocol coll...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
02 March 2019
|
| In: |
Journal of clinical periodontology
Year: 2019, Jahrgang: 46, Heft: 4, Pages: 491-501 |
| ISSN: | 1600-051X |
| DOI: | 10.1111/jcpe.13096 |
| Online-Zugang: | Verlag, Volltext: https://doi.org/10.1111/jcpe.13096 Verlag, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/jcpe.13096 
|
| Verfasserangaben: | Peter Eickholz, Raphael Koch, Thomas Kocher, Thomas Hoffmann, Ti-Sun Kim, Joerg Meyle, Doğan Kaner, Ulrich Schlagenhauf, Dag Harmsen, Inga Harks, Benjamin Ehmke |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1682037983 | ||
| 003 | DE-627 | ||
| 005 | 20220830090616.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 191118s2019 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1111/jcpe.13096 |2 doi | |
| 035 | |a (DE-627)1682037983 | ||
| 035 | |a (DE-599)KXP1682037983 | ||
| 035 | |a (OCoLC)1341251187 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Eickholz, Peter |d 1963- |e VerfasserIn |0 (DE-588)17206063X |0 (DE-627)69696533X |0 (DE-576)13293485X |4 aut | |
| 245 | 1 | 0 | |a Clinical benefits of systemic amoxicillin/metronidazole may depend on periodontitis severity and patients' age |b an exploratory sub-analysis of the ABPARO trial |c Peter Eickholz, Raphael Koch, Thomas Kocher, Thomas Hoffmann, Ti-Sun Kim, Joerg Meyle, Doğan Kaner, Ulrich Schlagenhauf, Dag Harmsen, Inga Harks, Benjamin Ehmke |
| 264 | 1 | |c 02 March 2019 | |
| 300 | |a 11 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 18.11.2019 | ||
| 520 | |a Aim The aim was to identify benefit thresholds for clinical variables. We hypothesize, if variables fall below or exceed these threshold levels, systemic amoxicillin/metronidazole may contribute to reducing progression of periodontitis. Material & Methods This is an explorative per-protocol collective analysis (n = 345) conducted on the placebo-controlled, multi-centre ABPARO trial (ClinicalTrials.gov NCT00707369). Patients received debridement with systemic amoxicillin 500 mg/metronidazole 400 mg (3×/day, 7 days, n = 170) or placebo (n = 175) and maintenance therapy every three months. To identify thresholds, each of the following baseline characteristics was classified into two groups (≥threshold value/<threshold value): bleeding on probing, extent of pocket probing depth (PPD) ≥ 5 mm, mean clinical attachment level and age. Treatment effect (% of sites with new attachment loss ≥ 1.3 mm at 27.5 months post-treatment) was calculated. Results Adjunctive antimicrobials reduced median new attachment loss in patients < 55 years (5.2%), or with ≥ 35% PPD ≥ 5 mm (4.5%) or with a mean attachment level > 5 mm (5.2%) at baseline compared to the placebo (9.0%, 11.6%, and 12.5%, respectively; p < 0.005). Conclusions The clinical benefits of systemic amoxicillin/metronidazole may depend on periodontitis severity and patients' age. | ||
| 650 | 4 | |a amoxicillin/metronidazole | |
| 650 | 4 | |a attachment loss | |
| 650 | 4 | |a clinical threshold | |
| 650 | 4 | |a periodontitis | |
| 650 | 4 | |a systemic antimicrobials | |
| 700 | 1 | |a Koch, Raphael |d 1982- |e VerfasserIn |0 (DE-588)1049793153 |0 (DE-627)78270073X |0 (DE-576)403791618 |4 aut | |
| 700 | 1 | |a Kocher, Thomas |e VerfasserIn |0 (DE-588)1181810973 |0 (DE-627)1662376642 |4 aut | |
| 700 | 1 | |a Hoffmann, Thomas |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kim, Ti-Sun |e VerfasserIn |0 (DE-588)107028842X |0 (DE-627)82440596X |0 (DE-576)430000936 |4 aut | |
| 700 | 1 | |a Meyle, Jörg |e VerfasserIn |0 (DE-588)1081095733 |0 (DE-627)845570277 |0 (DE-576)453941613 |4 aut | |
| 700 | 1 | |a Kaner, Doğan |d 1974- |e VerfasserIn |0 (DE-588)130365955 |0 (DE-627)500423393 |0 (DE-576)298152517 |4 aut | |
| 700 | 1 | |a Schlagenhauf, Ulrich |d 1954- |e VerfasserIn |0 (DE-588)123687594 |0 (DE-627)706395719 |0 (DE-576)214968251 |4 aut | |
| 700 | 1 | |a Harmsen, Dag |e VerfasserIn |4 aut | |
| 700 | 1 | |a Harks, Inga |e VerfasserIn |0 (DE-588)1122207077 |0 (DE-627)875228909 |0 (DE-576)481186808 |4 aut | |
| 700 | 1 | |a Ehmke, Benjamin |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of clinical periodontology |d Oxford [u.a.] : Wiley-Blackwell, 1974 |g 46(2019), 4, Seite 491-501 |h Online-Ressource |w (DE-627)323607381 |w (DE-600)2026349-1 |w (DE-576)093888732 |x 1600-051X |7 nnas |a Clinical benefits of systemic amoxicillin/metronidazole may depend on periodontitis severity and patients' age an exploratory sub-analysis of the ABPARO trial |
| 773 | 1 | 8 | |g volume:46 |g year:2019 |g number:4 |g pages:491-501 |g extent:11 |a Clinical benefits of systemic amoxicillin/metronidazole may depend on periodontitis severity and patients' age an exploratory sub-analysis of the ABPARO trial |
| 856 | 4 | 0 | |u https://doi.org/10.1111/jcpe.13096 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u https://onlinelibrary.wiley.com/doi/abs/10.1111/jcpe.13096 |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20191118 | ||
| 993 | |a Article | ||
| 994 | |a 2019 | ||
| 998 | |g 107028842X |a Kim, Ti-Sun |m 107028842X:Kim, Ti-Sun |d 50000 |e 50000PK107028842X |k 0/50000/ |p 5 | ||
| 999 | |a KXP-PPN1682037983 |e 3541624434 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"relHost":[{"part":{"issue":"4","extent":"11","year":"2019","text":"46(2019), 4, Seite 491-501","pages":"491-501","volume":"46"},"physDesc":[{"extent":"Online-Ressource"}],"title":[{"title_sort":"Journal of clinical periodontology","title":"Journal of clinical periodontology","subtitle":"the official publication of the European Federation of Periodontology"}],"origin":[{"dateIssuedKey":"1974","publisher":"Wiley-Blackwell ; Munksgaard ; Blackwell","publisherPlace":"Oxford [u.a.] ; Copenhagen ; Oxford [u.a.]","dateIssuedDisp":"1974-"}],"id":{"issn":["1600-051X"],"zdb":["2026349-1"],"doi":["10.1111/(ISSN)1600-051X"],"eki":["323607381"]},"type":{"media":"Online-Ressource","bibl":"periodical"},"language":["eng"],"note":["Gesehen am 08.04.22"],"pubHistory":["1.1974 -"],"recId":"323607381","disp":"Clinical benefits of systemic amoxicillin/metronidazole may depend on periodontitis severity and patients' age an exploratory sub-analysis of the ABPARO trialJournal of clinical periodontology"}],"person":[{"display":"Eickholz, Peter","family":"Eickholz","given":"Peter","role":"aut"},{"given":"Raphael","family":"Koch","display":"Koch, Raphael","role":"aut"},{"given":"Thomas","display":"Kocher, Thomas","family":"Kocher","role":"aut"},{"display":"Hoffmann, Thomas","family":"Hoffmann","given":"Thomas","role":"aut"},{"role":"aut","family":"Kim","display":"Kim, Ti-Sun","given":"Ti-Sun"},{"display":"Meyle, Jörg","family":"Meyle","given":"Jörg","role":"aut"},{"role":"aut","given":"Doğan","family":"Kaner","display":"Kaner, Doğan"},{"given":"Ulrich","family":"Schlagenhauf","display":"Schlagenhauf, Ulrich","role":"aut"},{"role":"aut","display":"Harmsen, Dag","family":"Harmsen","given":"Dag"},{"given":"Inga","display":"Harks, Inga","family":"Harks","role":"aut"},{"display":"Ehmke, Benjamin","family":"Ehmke","given":"Benjamin","role":"aut"}],"physDesc":[{"extent":"11 S."}],"title":[{"title":"Clinical benefits of systemic amoxicillin/metronidazole may depend on periodontitis severity and patients' age","subtitle":"an exploratory sub-analysis of the ABPARO trial","title_sort":"Clinical benefits of systemic amoxicillin/metronidazole may depend on periodontitis severity and patients' age"}],"origin":[{"dateIssuedDisp":"02 March 2019","dateIssuedKey":"2019"}],"language":["eng"],"id":{"eki":["1682037983"],"doi":["10.1111/jcpe.13096"]},"type":{"bibl":"article-journal","media":"Online-Ressource"},"note":["Gesehen am 18.11.2019"],"recId":"1682037983","name":{"displayForm":["Peter Eickholz, Raphael Koch, Thomas Kocher, Thomas Hoffmann, Ti-Sun Kim, Joerg Meyle, Doğan Kaner, Ulrich Schlagenhauf, Dag Harmsen, Inga Harks, Benjamin Ehmke"]}} | ||
| SRT | |a EICKHOLZPECLINICALBE0220 | ||