High endothelial venules are associated with microsatellite instability, hereditary background and immune evasion in colorectal cancer
BACKGROUND: Microsatellite-unstable (MSI) tumours show a high load of mutational neoantigens, as a consequence of DNA mismatch repair deficiency. Consequently, MSI tumours commonly present with dense immune infiltration and develop immune evasion mechanisms. Whether improved lymphocyte recruitment con...
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| Main Authors: | , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
30 July 2019
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| In: |
British journal of cancer
Year: 2019, Volume: 121, Issue: 5, Pages: 395-404 |
| ISSN: | 1532-1827 |
| DOI: | 10.1038/s41416-019-0514-6 |
| Online Access: | Verlag, Volltext: https://doi.org/10.1038/s41416-019-0514-6 Verlag: http://www.nature.com/articles/s41416-019-0514-6 
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| Author Notes: | Pauline L. Pfuderer, Alexej Ballhausen, Florian Seidler, Hans-Jürgen Stark, Niels Grabe, Ian M. Frayling, Ann Ager, Magnus von Knebel Doeberitz, Matthias Kloor & Aysel Ahadova |
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| 245 | 1 | 0 | |a High endothelial venules are associated with microsatellite instability, hereditary background and immune evasion in colorectal cancer |c Pauline L. Pfuderer, Alexej Ballhausen, Florian Seidler, Hans-Jürgen Stark, Niels Grabe, Ian M. Frayling, Ann Ager, Magnus von Knebel Doeberitz, Matthias Kloor & Aysel Ahadova |
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| 520 | |a BACKGROUND: Microsatellite-unstable (MSI) tumours show a high load of mutational neoantigens, as a consequence of DNA mismatch repair deficiency. Consequently, MSI tumours commonly present with dense immune infiltration and develop immune evasion mechanisms. Whether improved lymphocyte recruitment contributes to the pronounced immune infiltration in MSI tumours is unknown. We analysed the density of high endothelial venules (HEV) and postcapillary blood vessels specialised for lymphocyte trafficking, in MSI colorectal cancers (CRC). - METHODS: HEV density was determined by immunohistochemical staining of FFPE tissue sections from MSI (n = 48) and microsatellite-stable (MSS, n = 35) CRCs. Associations with clinical and pathological variables were analysed. - RESULTS: We found elevated HEV densities in MSI compared with MSS CRCs (median 0.049 vs 0.000 counts/mm2, respectively, p = 0.0002), with the highest densities in Lynch syndrome MSI CRCs. Dramatically elevated HEV densities were observed in B2M-mutant Lynch syndrome CRCs, pointing towards a link between lymphocyte recruitment and immune evasion (median 0.485 vs 0.0885 counts/mm2 in B2M-wild-type tumours, p = 0.0237). - CONCLUSIONS: Our findings for the first time indicate a significant contribution of lymphocyte trafficking in immune responses against MSI CRC, particularly in the context of Lynch syndrome. High HEV densities in B2M-mutant tumours underline the significance of immunoediting during tumour evolution. | ||
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