Induction of HIV transcription by Nef involves Lck activation and protein kinase C[theta] raft recruitment leading to activation of ERK1/2 but not NF[kappa]B

The Nef protein of HIV-1 is a key promoter of disease progression, owing to its dramatic yet ill-defined impact on viral replication. Previously, we have shown that Nef enhances embryonic ectodermal development Tat-mediated transcription in a manner depending on Lck and the cytoplasmic sequestration...

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Main Authors: Witte, Vanessa Alexandra (Author) , Laffert, Bernd (Author) , Gintschel, Patricia (Author) , Krautkrämer, Ellen (Author) , Blume, Katja (Author) , Fackler, Oliver Till (Author) , Baur, Andreas S. (Author)
Format: Article (Journal)
Language:English
Published: December 15, 2008
In: The journal of immunology
Year: 2008, Volume: 181, Issue: 12, Pages: 8425-8432
ISSN:1550-6606
DOI:10.4049/jimmunol.181.12.8425
Online Access:Verlag, Volltext: https://doi.org/10.4049/jimmunol.181.12.8425
Verlag, Volltext: https://www.jimmunol.org/content/181/12/8425
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Author Notes:Vanessa Witte, Bernd Laffert, Patricia Gintschel, Ellen Krautkrämer, Katja Blume, Oliver T. Fackler, and Andreas S. Baur
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Induction of HIV transcription by Nef involves Lck activation and protein kinase C[theta] raft recruitment leading to activation of ERK1/2 but not NF[kappa]B by Witte, Vanessa Alexandra (Author) , Laffert, Bernd (Author) , Gintschel, Patricia (Author) ,


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Article (Journal)