Induction of HIV transcription by Nef involves Lck activation and protein kinase C[theta] raft recruitment leading to activation of ERK1/2 but not NF[kappa]B
The Nef protein of HIV-1 is a key promoter of disease progression, owing to its dramatic yet ill-defined impact on viral replication. Previously, we have shown that Nef enhances embryonic ectodermal development Tat-mediated transcription in a manner depending on Lck and the cytoplasmic sequestration...
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| Main Authors: | , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
December 15, 2008
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| In: |
The journal of immunology
Year: 2008, Volume: 181, Issue: 12, Pages: 8425-8432 |
| ISSN: | 1550-6606 |
| DOI: | 10.4049/jimmunol.181.12.8425 |
| Online Access: | Verlag, Volltext: https://doi.org/10.4049/jimmunol.181.12.8425 Verlag, Volltext: https://www.jimmunol.org/content/181/12/8425 |
| Author Notes: | Vanessa Witte, Bernd Laffert, Patricia Gintschel, Ellen Krautkrämer, Katja Blume, Oliver T. Fackler, and Andreas S. Baur |