Active medulloblastoma enhancers reveal subgroup-specific cellular origins
Genomic studies of the paediatric brain tumour medulloblastoma have revealed four clinically distinct molecular subgroups. In this study, the authors map active gene regulatory elements in 28 primary medulloblastoma tissues to reveal differentially regulated enhancers across the different subgroups....
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| Hauptverfasser: | , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
27 January 2016
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| In: |
Nature
Year: 2016, Jahrgang: 530, Heft: 7588, Pages: 57-62 |
| ISSN: | 1476-4687 |
| DOI: | 10.1038/nature16546 |
| Online-Zugang: | Verlag, Volltext: https://doi.org/10.1038/nature16546 Verlag: https://www.nature.com/articles/nature16546 
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| Verfasserangaben: | Charles Y. Lin, Serap Erkek, Yiai Tong, Linlin Yin, Alexander J. Federation, Marc Zapatka, Parthiv Haldipur, Daisuke Kawauchi, Thomas Risch, Hans-Jörg Warnatz, Barbara C. Worst, Bensheng Ju, Brent A. Orr, Rhamy Zeid, Donald R. Polaski, Maia Segura-Wang, Sebastian M. Waszak, David T.W. Jones, Marcel Kool, Volker Hovestadt, Ivo Buchhalter, Laura Sieber, Pascal Johann, Lukas Chavez, Stefan Gröschel, Marina Ryzhova, Andrey Korshunov, Wenbiao Chen, Victor V. Chizhikov, Kathleen J. Millen, Vyacheslav Amstislavskiy, Hans Lehrach, Marie-Laure Yaspo, Roland Eils, Peter Lichter, Jan O. Korbel, Stefan M. Pfister, James E. Bradner & Paul A. Northcott |
MARC
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| 520 | |a Genomic studies of the paediatric brain tumour medulloblastoma have revealed four clinically distinct molecular subgroups. In this study, the authors map active gene regulatory elements in 28 primary medulloblastoma tissues to reveal differentially regulated enhancers across the different subgroups. The results allow insight into the transcription factors that characterize subgroup divergence and the cellular origin of the poorly characterized Group 3 and 4 subgroups. | ||
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