Patients with malignant lymphoma and HIV infection experiencing remission after first-line treatment have an excellent prognosis
Background - Malignant lymphoma is still the leading cause of death among AIDS-related diseases. - Patients and Methods - We performed a retrospective analysis of 50 HIV-positive lymphoma patients. The median interval between HIV and malignant lymphoma diagnosis was 4 years. Eight patients (16%) had...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
30 May 2019
|
| In: |
Clinical lymphoma, myeloma & leukemia
Year: 2019, Volume: 19, Issue: 10, Pages: e581-e587 |
| ISSN: | 2152-2669 |
| DOI: | 10.1016/j.clml.2019.05.019 |
| Online Access: | Verlag, Volltext: https://doi.org/10.1016/j.clml.2019.05.019 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S215226501831718X 
|
| Author Notes: | Katharina Kriegsmann, Julia S. Klee, Manfred Hensel, Eike C. Buss, Mark Kriegsmann, Martin Cremer, Anthony D. Ho, Gerlinde Egerer, Patrick Wuchter, Mathias Witzens-Harig |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1682409031 | ||
| 003 | DE-627 | ||
| 005 | 20240323101727.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 191121s2019 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.clml.2019.05.019 |2 doi | |
| 035 | |a (DE-627)1682409031 | ||
| 035 | |a (DE-599)KXP1682409031 | ||
| 035 | |a (OCoLC)1341278359 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Kriegsmann, Katharina |d 1986- |e VerfasserIn |0 (DE-588)1049422449 |0 (DE-627)781924006 |0 (DE-576)40339774X |4 aut | |
| 245 | 1 | 0 | |a Patients with malignant lymphoma and HIV infection experiencing remission after first-line treatment have an excellent prognosis |c Katharina Kriegsmann, Julia S. Klee, Manfred Hensel, Eike C. Buss, Mark Kriegsmann, Martin Cremer, Anthony D. Ho, Gerlinde Egerer, Patrick Wuchter, Mathias Witzens-Harig |
| 264 | 1 | |c 30 May 2019 | |
| 300 | |a 7 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 21.11.2019 | ||
| 520 | |a Background - Malignant lymphoma is still the leading cause of death among AIDS-related diseases. - Patients and Methods - We performed a retrospective analysis of 50 HIV-positive lymphoma patients. The median interval between HIV and malignant lymphoma diagnosis was 4 years. Eight patients (16%) had Hodgkin lymphoma and 42 (84%) non-Hodgkin lymphoma. Among non-Hodgkin lymphoma patients, diffuse large B-cell lymphoma (n = 18, 42%), Burkitt lymphoma (n = 11, 26%), and plasmoblastic lymphoma (n = 5, 12%) were the most frequent entities. - Results - Lymphoma was treated according to standard protocols. Forty-four patients (88%) received combination antiretroviral therapy, 2 (4%) were not treated, and in 4 (8%) the HIV treatment status was not clarified. Response to first-line therapy was complete response (CR) in 24 (56%), partial response (PR) in 15 (35%), and stable disease in 1 (2%). Three patients (7%) developed progressive disease, and 9 (18%) experienced relapse after CR or PR. At a median observation period of 31 (range, 0.4-192) months, the 1-, 2-, and 5-year overall survival was 87%, 79%, and 76%, respectively. At univariate analysis, remission status after first-line treatment was predictive of outcome, as the 2-year overall survival was 95%, 66%, and 0 for patients with CR, with PR, and with progressive disease (P < .001). Results of the multivariate analysis revealed lactate dehydrogenase concentration at lymphoma diagnosis (P = .046) and relapse (P = .050) to be independent factors for overall survival. - Conclusion - First-line treatment of lymphoma in HIV positive patients is crucial. Patients who experienced and maintained a first CR had a favorable prognosis. | ||
| 650 | 4 | |a Hodgkin lymphoma | |
| 650 | 4 | |a Human immunodeficiency virus | |
| 650 | 4 | |a Non-Hodgkin lymphoma | |
| 650 | 4 | |a Overall survival | |
| 650 | 4 | |a Progression-free survival | |
| 700 | 1 | |a Klee, Julia |d 1984- |e VerfasserIn |0 (DE-588)1125156198 |0 (DE-627)879485566 |0 (DE-576)483358487 |4 aut | |
| 700 | 1 | |a Hensel, Manfred |e VerfasserIn |4 aut | |
| 700 | 1 | |a Buß, Eike Christian |d 1974- |e VerfasserIn |0 (DE-588)128723696 |0 (DE-627)37867658X |0 (DE-576)297299654 |4 aut | |
| 700 | 1 | |a Kriegsmann, Mark |d 1987- |e VerfasserIn |0 (DE-588)103740324X |0 (DE-627)755668782 |0 (DE-576)39141870X |4 aut | |
| 700 | 1 | |a Cremer, Martin |e VerfasserIn |0 (DE-588)1084363852 |0 (DE-627)848800796 |0 (DE-576)456316078 |4 aut | |
| 700 | 1 | |a Ho, Anthony Dick |d 1948- |e VerfasserIn |0 (DE-588)108692477 |0 (DE-627)504904205 |0 (DE-576)19010466X |4 aut | |
| 700 | 1 | |a Egerer, Gerlinde |e VerfasserIn |0 (DE-588)105502168X |0 (DE-627)792516745 |0 (DE-576)167430882 |4 aut | |
| 700 | 1 | |a Wuchter, Patrick |d 1975- |e VerfasserIn |0 (DE-588)123450284 |0 (DE-627)082563624 |0 (DE-576)184642574 |4 aut | |
| 700 | 1 | |a Witzens-Harig, Mathias |e VerfasserIn |0 (DE-588)1050736516 |0 (DE-627)784812322 |0 (DE-576)404988970 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Clinical lymphoma, myeloma & leukemia |d Amsterdam [u.a.] : Elsevier, 2010 |g 19(2019), 10, Seite e581-e587 |h Online-Ressource |w (DE-627)620142014 |w (DE-600)2540998-0 |w (DE-576)358408776 |x 2152-2669 |7 nnas |a Patients with malignant lymphoma and HIV infection experiencing remission after first-line treatment have an excellent prognosis |
| 773 | 1 | 8 | |g volume:19 |g year:2019 |g number:10 |g pages:e581-e587 |g extent:7 |a Patients with malignant lymphoma and HIV infection experiencing remission after first-line treatment have an excellent prognosis |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.clml.2019.05.019 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u http://www.sciencedirect.com/science/article/pii/S215226501831718X |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20191121 | ||
| 993 | |a Article | ||
| 994 | |a 2019 | ||
| 998 | |g 1050736516 |a Witzens-Harig, Mathias |m 1050736516:Witzens-Harig, Mathias |d 910000 |d 910100 |e 910000PW1050736516 |e 910100PW1050736516 |k 0/910000/ |k 1/910000/910100/ |p 10 |y j | ||
| 998 | |g 123450284 |a Wuchter, Patrick |m 123450284:Wuchter, Patrick |d 60000 |d 63500 |e 60000PW123450284 |e 63500PW123450284 |k 0/60000/ |k 1/60000/63500/ |p 9 | ||
| 998 | |g 105502168X |a Egerer, Gerlinde |m 105502168X:Egerer, Gerlinde |d 910000 |d 910100 |e 910000PE105502168X |e 910100PE105502168X |k 0/910000/ |k 1/910000/910100/ |p 8 | ||
| 998 | |g 108692477 |a Ho, Anthony Dick |m 108692477:Ho, Anthony Dick |d 910000 |d 910100 |e 910000PH108692477 |e 910100PH108692477 |k 0/910000/ |k 1/910000/910100/ |p 7 | ||
| 998 | |g 1084363852 |a Cremer, Martin |m 1084363852:Cremer, Martin |d 910000 |d 910100 |e 910000PC1084363852 |e 910100PC1084363852 |k 0/910000/ |k 1/910000/910100/ |p 6 | ||
| 998 | |g 103740324X |a Kriegsmann, Mark |m 103740324X:Kriegsmann, Mark |d 910000 |d 910100 |e 910000PK103740324X |e 910100PK103740324X |k 0/910000/ |k 1/910000/910100/ |p 5 | ||
| 998 | |g 128723696 |a Buß, Eike Christian |m 128723696:Buß, Eike Christian |d 910000 |d 910100 |e 910000PB128723696 |e 910100PB128723696 |k 0/910000/ |k 1/910000/910100/ |p 3 | ||
| 998 | |g 1125156198 |a Klee, Julia |m 1125156198:Klee, Julia |d 910000 |d 910100 |e 910000PK1125156198 |e 910100PK1125156198 |k 0/910000/ |k 1/910000/910100/ |p 2 | ||
| 998 | |g 1049422449 |a Kriegsmann, Katharina |m 1049422449:Kriegsmann, Katharina |d 910000 |d 910100 |e 910000PK1049422449 |e 910100PK1049422449 |k 0/910000/ |k 1/910000/910100/ |p 1 |x j | ||
| 999 | |a KXP-PPN1682409031 |e 3544020777 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"id":{"eki":["1682409031"],"doi":["10.1016/j.clml.2019.05.019"]},"name":{"displayForm":["Katharina Kriegsmann, Julia S. Klee, Manfred Hensel, Eike C. Buss, Mark Kriegsmann, Martin Cremer, Anthony D. Ho, Gerlinde Egerer, Patrick Wuchter, Mathias Witzens-Harig"]},"physDesc":[{"extent":"7 S."}],"recId":"1682409031","note":["Gesehen am 21.11.2019"],"language":["eng"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"title":[{"title_sort":"Patients with malignant lymphoma and HIV infection experiencing remission after first-line treatment have an excellent prognosis","title":"Patients with malignant lymphoma and HIV infection experiencing remission after first-line treatment have an excellent prognosis"}],"relHost":[{"id":{"eki":["620142014"],"issn":["2152-2669"],"zdb":["2540998-0"]},"part":{"pages":"e581-e587","issue":"10","text":"19(2019), 10, Seite e581-e587","extent":"7","year":"2019","volume":"19"},"titleAlt":[{"title":"Clinical lymphoma, myeloma and leukemia"}],"pubHistory":["10.2010 -"],"disp":"Patients with malignant lymphoma and HIV infection experiencing remission after first-line treatment have an excellent prognosisClinical lymphoma, myeloma & leukemia","physDesc":[{"extent":"Online-Ressource"}],"recId":"620142014","type":{"bibl":"periodical","media":"Online-Ressource"},"language":["eng"],"note":["Gesehen am 04.02.20"],"title":[{"title":"Clinical lymphoma, myeloma & leukemia","title_sort":"Clinical lymphoma, myeloma & leukemia"}],"origin":[{"publisher":"Elsevier ; CIG Media Group","publisherPlace":"Amsterdam [u.a.] ; Dallas, Tex.","dateIssuedKey":"2010","dateIssuedDisp":"2010-"}]}],"person":[{"display":"Kriegsmann, Katharina","family":"Kriegsmann","given":"Katharina","role":"aut"},{"display":"Klee, Julia","given":"Julia","role":"aut","family":"Klee"},{"display":"Hensel, Manfred","role":"aut","given":"Manfred","family":"Hensel"},{"role":"aut","given":"Eike Christian","family":"Buß","display":"Buß, Eike Christian"},{"family":"Kriegsmann","given":"Mark","role":"aut","display":"Kriegsmann, Mark"},{"display":"Cremer, Martin","family":"Cremer","given":"Martin","role":"aut"},{"display":"Ho, Anthony Dick","role":"aut","given":"Anthony Dick","family":"Ho"},{"display":"Egerer, Gerlinde","role":"aut","given":"Gerlinde","family":"Egerer"},{"display":"Wuchter, Patrick","family":"Wuchter","role":"aut","given":"Patrick"},{"role":"aut","given":"Mathias","family":"Witzens-Harig","display":"Witzens-Harig, Mathias"}],"origin":[{"dateIssuedKey":"2019","dateIssuedDisp":"30 May 2019"}]} | ||
| SRT | |a KRIEGSMANNPATIENTSWI3020 | ||