Entry of hepatitis B and hepatitis D virus into hepatocytes: Basic insights and clinical implications
For almost three decades following the discovery of the human Hepatitis B Virus (HBV) the early events of virus infection (attachment to hepatocytes, specific binding to a receptor on hepatocytes) remained enigmatic. The gradual improvement of tissue culture systems for HBV has enabled the identific...
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
12 April 2016
|
| In: |
Journal of hepatology
Year: 2016, Jahrgang: 64, Heft: 1, Supplement, Pages: S32-S40 |
| ISSN: | 1600-0641 |
| DOI: | 10.1016/j.jhep.2016.02.011 |
| Online-Zugang: | Verlag, Volltext: https://doi.org/10.1016/j.jhep.2016.02.011 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0168827816000921 
|
| Verfasserangaben: | Wenhui Li, Stephan Urban |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1683461029 | ||
| 003 | DE-627 | ||
| 005 | 20220817164205.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 191125s2016 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.jhep.2016.02.011 |2 doi | |
| 035 | |a (DE-627)1683461029 | ||
| 035 | |a (DE-599)KXP1683461029 | ||
| 035 | |a (OCoLC)1341278772 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Li, Wenhui |e VerfasserIn |0 (DE-588)1200490800 |0 (DE-627)168362209X |4 aut | |
| 245 | 1 | 0 | |a Entry of hepatitis B and hepatitis D virus into hepatocytes |b Basic insights and clinical implications |c Wenhui Li, Stephan Urban |
| 264 | 1 | |c 12 April 2016 | |
| 300 | |a 9 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 25.11.2019 | ||
| 520 | |a For almost three decades following the discovery of the human Hepatitis B Virus (HBV) the early events of virus infection (attachment to hepatocytes, specific binding to a receptor on hepatocytes) remained enigmatic. The gradual improvement of tissue culture systems for HBV has enabled the identification of viral determinants for viral infectivity and facilitated the discovery of the human sodium taurocholate co-transporting polypeptide (hNTCP) as a liver specific receptor of HBV and its satellite, the human Hepatitis Delta Virus (HDV). These findings are currently leading basic and clinical research activities in new directions. (1) Stable hNTCP-expressing cell lines have become a valuable platform to study the full HBV replication cycle from its native template, the cccDNA. (2) The suitability of NTCP complemented cell culture systems for high throughput screening approaches will facilitate identification of novel host factors involved in HBV replication (including those that determine the peculiar host specificity of HBV infection) and will enable identification and development of novel drug candidates for improved therapeutics. (3) Since NTCP is a major host-specific restriction factor for HBV and HDV, hNTCP-expressing animals provide the basis for future susceptible in vivo models. (4) The concept obtained with the entry inhibitor Myrcludex B demonstrates that NTCP is a suitable target for clinical interference with viral entry. This will foster further clinical approaches aiming at curative combination therapies. | ||
| 650 | 4 | |a Hepatitis B virus entry | |
| 650 | 4 | |a Hepatitis B virus receptor | |
| 650 | 4 | |a Myrcludex B | |
| 650 | 4 | |a NTCP | |
| 650 | 4 | |a SLC10A1 | |
| 700 | 1 | |a Urban, Stephan |e VerfasserIn |0 (DE-588)1060263599 |0 (DE-627)79935399X |0 (DE-576)174162049 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of hepatology |d Amsterdam [u.a.] : Elsevier Science, 1985 |g 64(2016), 1, Supplement, Seite S32-S40 |h Online-Ressource |w (DE-627)320984486 |w (DE-600)2027112-8 |w (DE-576)093888856 |x 1600-0641 |7 nnas |a Entry of hepatitis B and hepatitis D virus into hepatocytes Basic insights and clinical implications |
| 773 | 1 | 8 | |g volume:64 |g year:2016 |g number:1, Supplement |g pages:S32-S40 |g extent:9 |a Entry of hepatitis B and hepatitis D virus into hepatocytes Basic insights and clinical implications |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.jhep.2016.02.011 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u http://www.sciencedirect.com/science/article/pii/S0168827816000921 |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20191125 | ||
| 993 | |a Article | ||
| 994 | |a 2016 | ||
| 998 | |g 1060263599 |a Urban, Stephan |m 1060263599:Urban, Stephan |d 910000 |d 911700 |e 910000PU1060263599 |e 911700PU1060263599 |k 0/910000/ |k 1/910000/911700/ |p 2 |y j | ||
| 999 | |a KXP-PPN1683461029 |e 354971100X | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"note":["Gesehen am 25.11.2019"],"relHost":[{"part":{"extent":"9","text":"64(2016), 1, Supplement, Seite S32-S40","pages":"S32-S40","volume":"64","year":"2016","issue":"1, Supplement"},"origin":[{"publisherPlace":"Amsterdam [u.a.] ; [Erscheinungsort nicht ermittelbar]","dateIssuedDisp":"1985-","dateIssuedKey":"1985","publisher":"Elsevier Science ; Wiley-Blackwell"}],"id":{"eki":["320984486"],"zdb":["2027112-8"],"issn":["1600-0641"]},"disp":"Entry of hepatitis B and hepatitis D virus into hepatocytes Basic insights and clinical implicationsJournal of hepatology","recId":"320984486","title":[{"title_sort":"Journal of hepatology","subtitle":"official journal of the European Association for the Study of the Liver","title":"Journal of hepatology"}],"language":["eng"],"pubHistory":["1.1985 -"],"physDesc":[{"extent":"Online-Ressource"}],"note":["Gesehen am 18.02.2020"],"type":{"media":"Online-Ressource","bibl":"periodical"}}],"title":[{"title":"Entry of hepatitis B and hepatitis D virus into hepatocytes","subtitle":"Basic insights and clinical implications","title_sort":"Entry of hepatitis B and hepatitis D virus into hepatocytes"}],"person":[{"family":"Li","given":"Wenhui","role":"aut","display":"Li, Wenhui"},{"display":"Urban, Stephan","family":"Urban","given":"Stephan","role":"aut"}],"physDesc":[{"extent":"9 S."}],"language":["eng"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"origin":[{"dateIssuedDisp":"12 April 2016","dateIssuedKey":"2016"}],"id":{"doi":["10.1016/j.jhep.2016.02.011"],"eki":["1683461029"]},"recId":"1683461029","name":{"displayForm":["Wenhui Li, Stephan Urban"]}} | ||
| SRT | |a LIWENHUIURENTRYOFHEP1220 | ||