Genome organization and DNA accessibility control antigenic variation in trypanosomes
Long-read sequencing allows the assembly of antigen-gene arrays in Trypanosoma brucei and, coupled with deletion experiments, demonstrates that histone variants act as a molecular link between genome architecture, chromatin conformation and antigen variation.
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
17 October 2018
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| In: |
Nature
Year: 2018, Volume: 563, Issue: 7729, Pages: 121-125 |
| ISSN: | 1476-4687 |
| DOI: | 10.1038/s41586-018-0619-8 |
| Online Access: | Verlag, Pay-per-use, Volltext: https://doi.org/10.1038/s41586-018-0619-8 Verlag, Pay-per-use, Volltext: https://www.nature.com/articles/s41586-018-0619-8 
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| Author Notes: | Laura S.M. Müller, Raúl O. Cosentino, Konrad U. Förstner, Julien Guizetti, Carolin Wedel, Noam Kaplan, Christian J. Janzen, Panagiota Arampatzi, Jörg Vogel, Sascha Steinbiss, Thomas D. Otto, Antoine-Emmanuel Saliba, Robert P. Sebra & T. Nicolai Siegel |
| Summary: | Long-read sequencing allows the assembly of antigen-gene arrays in Trypanosoma brucei and, coupled with deletion experiments, demonstrates that histone variants act as a molecular link between genome architecture, chromatin conformation and antigen variation. |
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| Item Description: | Gesehen am 27.11.2019 Laura S.M. Müller and Raúl O. Cosentino contributed equally |
| Physical Description: | Online Resource |
| ISSN: | 1476-4687 |
| DOI: | 10.1038/s41586-018-0619-8 |