Genome organization and DNA accessibility control antigenic variation in trypanosomes
Long-read sequencing allows the assembly of antigen-gene arrays in Trypanosoma brucei and, coupled with deletion experiments, demonstrates that histone variants act as a molecular link between genome architecture, chromatin conformation and antigen variation.
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
17 October 2018
|
| In: |
Nature
Year: 2018, Volume: 563, Issue: 7729, Pages: 121-125 |
| ISSN: | 1476-4687 |
| DOI: | 10.1038/s41586-018-0619-8 |
| Online Access: | Verlag, Pay-per-use, Volltext: https://doi.org/10.1038/s41586-018-0619-8 Verlag, Pay-per-use, Volltext: https://www.nature.com/articles/s41586-018-0619-8 
|
| Author Notes: | Laura S.M. Müller, Raúl O. Cosentino, Konrad U. Förstner, Julien Guizetti, Carolin Wedel, Noam Kaplan, Christian J. Janzen, Panagiota Arampatzi, Jörg Vogel, Sascha Steinbiss, Thomas D. Otto, Antoine-Emmanuel Saliba, Robert P. Sebra & T. Nicolai Siegel |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1683639278 | ||
| 003 | DE-627 | ||
| 005 | 20220817164758.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 191127s2018 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1038/s41586-018-0619-8 |2 doi | |
| 035 | |a (DE-627)1683639278 | ||
| 035 | |a (DE-599)KXP1683639278 | ||
| 035 | |a (OCoLC)1341278894 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 32 |2 sdnb | ||
| 100 | 1 | |a Müller, Laura S. M. |d 1990- |e VerfasserIn |0 (DE-588)1200502981 |0 (DE-627)1683640357 |4 aut | |
| 245 | 1 | 0 | |a Genome organization and DNA accessibility control antigenic variation in trypanosomes |c Laura S.M. Müller, Raúl O. Cosentino, Konrad U. Förstner, Julien Guizetti, Carolin Wedel, Noam Kaplan, Christian J. Janzen, Panagiota Arampatzi, Jörg Vogel, Sascha Steinbiss, Thomas D. Otto, Antoine-Emmanuel Saliba, Robert P. Sebra & T. Nicolai Siegel |
| 264 | 1 | |c 17 October 2018 | |
| 300 | |a 5 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 27.11.2019 | ||
| 500 | |a Laura S.M. Müller and Raúl O. Cosentino contributed equally | ||
| 520 | |a Long-read sequencing allows the assembly of antigen-gene arrays in Trypanosoma brucei and, coupled with deletion experiments, demonstrates that histone variants act as a molecular link between genome architecture, chromatin conformation and antigen variation. | ||
| 700 | 1 | |a Cosentino, Raúl O. |e VerfasserIn |0 (DE-588)1200503627 |0 (DE-627)168364123X |4 aut | |
| 700 | 1 | |a Guizetti, Julien |e VerfasserIn |0 (DE-588)1186736615 |0 (DE-627)1666006343 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Nature |d London [u.a.] : Nature Publ. Group, 1869 |g 563(2018), 7729, Seite 121-125 |h Online-Ressource |w (DE-627)240151402 |w (DE-600)1413423-8 |w (DE-576)079718426 |x 1476-4687 |7 nnas |a Genome organization and DNA accessibility control antigenic variation in trypanosomes |
| 773 | 1 | 8 | |g volume:563 |g year:2018 |g number:7729 |g pages:121-125 |g extent:5 |a Genome organization and DNA accessibility control antigenic variation in trypanosomes |
| 856 | 4 | 0 | |u https://doi.org/10.1038/s41586-018-0619-8 |x Verlag |x Resolving-System |z Pay-per-use |3 Volltext |
| 856 | 4 | 0 | |u https://www.nature.com/articles/s41586-018-0619-8 |x Verlag |z Pay-per-use |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20191127 | ||
| 993 | |a Article | ||
| 994 | |a 2018 | ||
| 998 | |g 1186736615 |a Guizetti, Julien |m 1186736615:Guizetti, Julien |d 910000 |d 911700 |e 910000PG1186736615 |e 911700PG1186736615 |k 0/910000/ |k 1/910000/911700/ |p 4 | ||
| 999 | |a KXP-PPN1683639278 |e 355051901X | ||
| BIB | |a Y | ||
| SER | |a newspaper | ||
| JSO | |a {"name":{"displayForm":["Laura S.M. Müller, Raúl O. Cosentino, Konrad U. Förstner, Julien Guizetti, Carolin Wedel, Noam Kaplan, Christian J. Janzen, Panagiota Arampatzi, Jörg Vogel, Sascha Steinbiss, Thomas D. Otto, Antoine-Emmanuel Saliba, Robert P. Sebra & T. Nicolai Siegel"]},"origin":[{"dateIssuedKey":"2018","dateIssuedDisp":"17 October 2018"}],"id":{"doi":["10.1038/s41586-018-0619-8"],"eki":["1683639278"]},"physDesc":[{"extent":"5 S."}],"relHost":[{"recId":"240151402","language":["eng"],"type":{"bibl":"newspaper","media":"Online-Ressource"},"disp":"Genome organization and DNA accessibility control antigenic variation in trypanosomesNature","note":["Gesehen am 19.02.2019"],"titleAlt":[{"title":"Nature <London>"},{"title":"Nature"}],"part":{"issue":"7729","pages":"121-125","year":"2018","extent":"5","volume":"563","text":"563(2018), 7729, Seite 121-125"},"pubHistory":["1.1869/70 - ; auch mit durchgehender Nr.-Zählung"],"title":[{"title_sort":"Nature","title":"Nature","subtitle":"international weekly journal of science"}],"physDesc":[{"extent":"Online-Ressource"}],"id":{"issn":["1476-4687"],"eki":["240151402"],"zdb":["1413423-8"]},"origin":[{"dateIssuedDisp":"1869-","dateIssuedKey":"1869","publisher":"Nature Publ. Group ; Macmillan","publisherPlace":"London [u.a.] ; London"}]}],"person":[{"roleDisplay":"VerfasserIn","display":"Müller, Laura S. M.","role":"aut","family":"Müller","given":"Laura S. M."},{"given":"Raúl O.","family":"Cosentino","role":"aut","roleDisplay":"VerfasserIn","display":"Cosentino, Raúl O."},{"role":"aut","roleDisplay":"VerfasserIn","display":"Guizetti, Julien","given":"Julien","family":"Guizetti"}],"title":[{"title_sort":"Genome organization and DNA accessibility control antigenic variation in trypanosomes","title":"Genome organization and DNA accessibility control antigenic variation in trypanosomes"}],"note":["Gesehen am 27.11.2019","Laura S.M. Müller and Raúl O. Cosentino contributed equally"],"type":{"media":"Online-Ressource","bibl":"article-newspaper"},"language":["eng"],"recId":"1683639278"} | ||
| SRT | |a MUELLERLAUGENOMEORGA1720 | ||