The association of high-sensitivity cardiac troponin I and T with echocardiographic stages of heart failure with preserved ejection fraction
Background: This study evaluates the associations between high-sensitivity troponin I and T (hs-TnI/hs-TnT) and the stages of heart failure with preserved ejection fraction (HFpEF)/diastolic dysfunction. Methods: Blood samples for biomarker measurements (hs-TnI/hs-TnT/NT-proBNP) were collected withi...
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| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
May 21, 2019
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| In: |
Annals of clinical biochemistry
Year: 2019, Volume: 56, Issue: 4, Pages: 431-441 |
| ISSN: | 1758-1001 |
| DOI: | 10.1177/0004563219841644 |
| Online Access: | Verlag, Volltext: https://doi.org/10.1177/0004563219841644
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| Author Notes: | Julia Hoffmann, Michael Behnes, Uzair Ansari, Kathrin Weidner, Philip Kuche, Jonas Rusnak, Seung-Hyun Kim, Michele Natale, Nadine Reckord, Siegfried Lang, Ursula Hoffmann, Thomas Bertsch, Marc Fatar, Martin Borggrefe, Ibrahim Akin |
MARC
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| 245 | 1 | 4 | |a The association of high-sensitivity cardiac troponin I and T with echocardiographic stages of heart failure with preserved ejection fraction |c Julia Hoffmann, Michael Behnes, Uzair Ansari, Kathrin Weidner, Philip Kuche, Jonas Rusnak, Seung-Hyun Kim, Michele Natale, Nadine Reckord, Siegfried Lang, Ursula Hoffmann, Thomas Bertsch, Marc Fatar, Martin Borggrefe, Ibrahim Akin |
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| 520 | |a Background: This study evaluates the associations between high-sensitivity troponin I and T (hs-TnI/hs-TnT) and the stages of heart failure with preserved ejection fraction (HFpEF)/diastolic dysfunction. Methods: Blood samples for biomarker measurements (hs-TnI/hs-TnT/NT-proBNP) were collected within 24 h of routine echocardiographic examination. Patients with left ventricular ejection fraction <50%, right ventricular dysfunction and moderate-to-severe valvular heart disease were excluded. Graduation of diastolic dysfunction was determined according to current guidelines. Results: A total of 70 patients were included. Hs-TnT concentrations increased significantly according to the progression of diastolic dysfunction (P = 0.024). Hs-TnT was able to discriminate patients with diastolic dysfunction grade III (AUC = 0.737; P = 0.013), while NT-proBNP revealed a greater AUC (AUC 0.798; P = 0.002). Concentrations of hs-TnI increased only numerically according to the increasing stages of diastolic dysfunction (P = 0.353). In multivariable logistic regression models, hs-TnT concentrations > 28 ng/L were associated with diastolic dysfunction grade III (OR = 4.7, P = 0.024), even after adjusting for NT-proBNP. Conclusion: Increasing concentrations of hs-TnT may reflect the stages of diastolic dysfunction being assessed by echocardiography, whereas hs-TnI does not show any association with diastolic dysfunction. | ||
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