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Using wearables to screen motor performance deterioration because of cancer and chemotherapy-induced peripheral neuropathy (CIPN) in adults: toward an early diagnosis of CIPN

Objective - An essential component for optimizing quality of life in adults with cancer is determining the degree to which therapy may negatively impact motor-performance, so that patients can maintain their quality of life and independence. This study examined whether instrumented gait and balance...

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Main Authors: Zahiri, Mohsen (Author) , Chen, Kevin M. (Author) , Zhou, He (Author) , Nguyen, Hung (Author) , Workeneh, Biruh T. (Author) , Yellapragada, Sarvari V. (Author) , Sada, Yvonne H. (Author) , Schwenk, Michael (Author) , Najafi, Bijan (Author)
Format: Article (Journal)
Language:English
Published: 18 January 2019
In: Journal of geriatric oncology
Year: 2019, Volume: 10, Issue: 6, Pages: 960-967
ISSN:1879-4076
DOI:10.1016/j.jgo.2019.01.010
Online Access:Verlag, Volltext: https://doi.org/10.1016/j.jgo.2019.01.010
Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S1879406818303655
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Author Notes:Mohsen Zahiri, Kevin M. Chen, He Zhou, Hung Nguyen, Biruh T. Workeneh, Sarvari V. Yellapragada, Yvonne H. Sada, Michael Schwenk, Bijan Najafi

MARC

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520 |a Objective - An essential component for optimizing quality of life in adults with cancer is determining the degree to which therapy may negatively impact motor-performance, so that patients can maintain their quality of life and independence. This study examined whether instrumented gait and balance could determine the magnitude of deterioration in motor-performance from chemotherapy-induced peripheral neuropathy (CIPN). - Methods - We recruited 84 adults with cancer (age=71.1±9.7years old, BMI=26.8±6.2kg/m2, gender=56%female) and 57 age-matched non-cancer patients (age=69.5±9.8years old, BMI=27.1±6.0kg/m2, gender=79%female). Based on clinical screening, the group with cancer was classified into two groups: participants with CIPN (CIPN+) and without CIPN (CIPN-). Gait and balance were quantified using validated wearables. The Vibration Perception Threshold (VPT) test was used to stratify the CIPN+ group into mild (Mild-CIPN) and severe (Severe-CIPN) subgroups. - Results - All gait and balance parameters were deteriorated in the group with cancer compared to non-cancer group with the largest effects observed for stride-time (11%, Cohen's effect size d=1.00, p<0.001) and eyes-closed ankle sway (94%, d=0.49, p=0.001). The same trend was observed when the Severe-CIPN subgroup was compared to the Mild-CIPN. VPT correlates significantly with motor deterioration, with the largest correlation found in stride-time (Rho=0.37, p=0.007). Severe-CIPN subjects were significantly older and overall had more deterioration in the majority of motor-performance parameters after adjusting for age (p<0.050). - Conclusion - These results confirmed the negative impact of CIPN on motor-performance with the largest effects on ankle stability and stride-time. VPT is a predictor of motor deterioration and may be used to determine the severity of CIPN symptom. 
650 4 |a Adults with cancer 
650 4 |a Balance 
650 4 |a Chemotherapy-Induced Peripheral Neuropathy 
650 4 |a Falls 
650 4 |a Gait 
650 4 |a Motor performance 
650 4 |a Neuropathy 
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