Neuronal vulnerability and multilineage diversity in multiple sclerosis

Single-cell RNA sequencing was used to construct a map of gene expression in lesions from brains of patients with multiple sclerosis, revealing distinct lineage- and region-specific transcriptomic changes associated with selective cortical neuron damage and glial activation.

Bibliographic Details

Main Authors:	Schirmer, Lucas (Author) , Velmeshev, Dmitry (Author) , Holmqvist, Staffan (Author) , Kaufmann, Max (Author) , Werneburg, Sebastian (Author) , Jung, Diane (Author) , Vistnes, Stephanie (Author) , Stockley, John H. (Author) , Young, Adam (Author) , Steindel, Maike (Author) , Tung, Brian (Author) , Goyal, Nitasha (Author) , Bhaduri, Aparna (Author) , Mayer, Simone (Author) , Engler, Jan Broder (Author) , Bayraktar, Omer A. (Author) , Franklin, Robin J. M. (Author) , Haeussler, Maximilian (Author) , Reynolds, Richard (Author) , Schafer, Dorothy P. (Author) , Friese, Manuel A. (Author) , Shiow, Lawrence R. (Author) , Kriegstein, Arnold R. (Author) , Rowitch, David H. (Author)
Format:	Article (Journal)
Language:	English
Published:	17 July 2019
In:	Nature Year: 2019, Volume: 573, Issue: 7772, Pages: 75-82
ISSN:	1476-4687
DOI:	10.1038/s41586-019-1404-z
Online Access:	Verlag, Volltext: https://doi.org/10.1038/s41586-019-1404-z Verlag, Volltext: https://www.nature.com/articles/s41586-019-1404-z
Author Notes:	Lucas Schirmer, Dmitry Velmeshev, Staffan Holmqvist, Max Kaufmann, Sebastian Werneburg, Diane Jung, Stephanie Vistnes, John H. Stockley, Adam Young, Maike Steindel, Brian Tung, Nitasha Goyal, Aparna Bhaduri, Simone Mayer, Jan Broder Engler, Omer A. Bayraktar, Robin J. M. Franklin, Maximilian Haeussler, Richard Reynolds, Dorothy P. Schafer, Manuel A. Friese, Lawrence R. Shiow, Arnold R. Kriegstein & David H. Rowitch