Outcome and prognosis after pancreatectomy in patients with solid pseudopapillary neoplasms
Background - Solid pseudopapillary neoplasms (SPN) are rare and represent approximately 4% of all cystic pancreatic tumors. The prognosis is excellent, although 10-15% of SPN patients show metastasis at the time of surgery or tumor recurrence during follow-up after pancreatectomy. Aim of the study w...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
14 June 2019
|
| In: |
Pancreatology
Year: 2019, Volume: 19, Issue: 5, Pages: 699-709 |
| ISSN: | 1424-3911 |
| DOI: | 10.1016/j.pan.2019.06.008 |
| Online Access: | Verlag, Volltext: https://doi.org/10.1016/j.pan.2019.06.008 Verlag: http://www.sciencedirect.com/science/article/pii/S142439031930609X 
|
| Author Notes: | Christine Tjaden, Matthias Hassenpflug, Ulf Hinz, Ulla Klaiber, Miriam Klauss, Markus W. Büchler, Thilo Hackert |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1684166802 | ||
| 003 | DE-627 | ||
| 005 | 20230426071241.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 191204s2019 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.pan.2019.06.008 |2 doi | |
| 035 | |a (DE-627)1684166802 | ||
| 035 | |a (DE-599)KXP1684166802 | ||
| 035 | |a (OCoLC)1341280430 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Tjaden, Christin |e VerfasserIn |0 (DE-588)103328145X |0 (DE-627)74081219X |0 (DE-576)380859521 |4 aut | |
| 245 | 1 | 0 | |a Outcome and prognosis after pancreatectomy in patients with solid pseudopapillary neoplasms |c Christine Tjaden, Matthias Hassenpflug, Ulf Hinz, Ulla Klaiber, Miriam Klauss, Markus W. Büchler, Thilo Hackert |
| 264 | 1 | |c 14 June 2019 | |
| 300 | |a 11 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 04.12.2019 | ||
| 520 | |a Background - Solid pseudopapillary neoplasms (SPN) are rare and represent approximately 4% of all cystic pancreatic tumors. The prognosis is excellent, although 10-15% of SPN patients show metastasis at the time of surgery or tumor recurrence during follow-up after pancreatectomy. Aim of the study was to analyze surgical management, risk factors for malignancy as well as long-term outcome and prognosis of this distinct tumor entity. - Method - All patients with pancreatic resection for SPN between 10/2001 and 07/2018 in the authors’ institution were identified from a prospective database. Clinicopathologic details, perioperative data and long-term follow-up results were retrospectively analyzed. - Results - Fifty-two patients were identified, 44 (85%) of them were female and the median age was 29 years (IQR 9-71). Seven (13%) patients showed a malignant behaviour of SPN with N1 (n=2) or M1 (n=1) disease at resection; 5 patients developed tumor recurrence, after a median of 21 months. During follow-up time (median 54 months) all patients were alive, the 5- and 10-year rates for disease-free survival were 89.0% and 81.6%, respectively. Significant risk factors for recurrence were age <18 years (p=0.0087) and parenchyma-preserving surgical approaches (p=0.0006). The postoperative long-term outcome showed ECOG=0-1 in all patients, with resection related exocrine insufficiency in 20 (41%) and diabetes mellitus in 2 (4%) patients. - Conclusions - Age<18 years is a significant risk factor for malignancy in SPN, and parenchyma preserving resections harbor a significant risk for tumor recurrence. As recurrence may occur late, a systematic life-long follow-up should be performed. | ||
| 650 | 4 | |a Follow-up | |
| 650 | 4 | |a Frantz tumor | |
| 650 | 4 | |a Malignancy | |
| 650 | 4 | |a Metastases | |
| 650 | 4 | |a Pancreas resection | |
| 700 | 1 | |a Hassenpflug, Matthias |d 1979- |e VerfasserIn |0 (DE-588)143006827 |0 (DE-627)641429479 |0 (DE-576)334578043 |4 aut | |
| 700 | 1 | |a Hinz, Ulf |e VerfasserIn |0 (DE-588)1022150499 |0 (DE-627)716927748 |0 (DE-576)175505284 |4 aut | |
| 700 | 1 | |a Klaiber, Ulla |d 1985- |e VerfasserIn |0 (DE-588)1045771155 |0 (DE-627)775079944 |0 (DE-576)399230939 |4 aut | |
| 700 | 1 | |a Klauß, Miriam |d 1978- |e VerfasserIn |0 (DE-588)130870552 |0 (DE-627)506783839 |0 (DE-576)29838728X |4 aut | |
| 700 | 1 | |a Büchler, Markus W. |d 1955- |e VerfasserIn |0 (DE-588)120893339 |0 (DE-627)080952526 |0 (DE-576)292434146 |4 aut | |
| 700 | 1 | |a Hackert, Thilo |d 1971- |e VerfasserIn |0 (DE-588)122158512 |0 (DE-627)70579346X |0 (DE-576)182659208 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Pancreatology |d Amsterdam : Elsevier, 2001 |g 19(2019), 5, Seite 699-709 |h Online-Ressource |w (DE-627)32764432X |w (DE-600)2043694-4 |w (DE-576)110513657 |x 1424-3911 |7 nnas |a Outcome and prognosis after pancreatectomy in patients with solid pseudopapillary neoplasms |
| 773 | 1 | 8 | |g volume:19 |g year:2019 |g number:5 |g pages:699-709 |g extent:11 |a Outcome and prognosis after pancreatectomy in patients with solid pseudopapillary neoplasms |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.pan.2019.06.008 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u http://www.sciencedirect.com/science/article/pii/S142439031930609X |x Verlag |
| 951 | |a AR | ||
| 992 | |a 20191204 | ||
| 993 | |a Article | ||
| 994 | |a 2019 | ||
| 998 | |g 122158512 |a Hackert, Thilo |m 122158512:Hackert, Thilo |d 910000 |d 910200 |e 910000PH122158512 |e 910200PH122158512 |k 0/910000/ |k 1/910000/910200/ |p 7 |y j | ||
| 998 | |g 120893339 |a Büchler, Markus W. |m 120893339:Büchler, Markus W. |d 910000 |d 910200 |e 910000PB120893339 |e 910200PB120893339 |k 0/910000/ |k 1/910000/910200/ |p 6 | ||
| 998 | |g 130870552 |a Klauß, Miriam |m 130870552:Klauß, Miriam |d 910000 |e 910000PK130870552 |k 0/910000/ |p 5 | ||
| 998 | |g 1045771155 |a Klaiber, Ulla |m 1045771155:Klaiber, Ulla |d 910000 |d 910200 |e 910000PK1045771155 |e 910200PK1045771155 |k 0/910000/ |k 1/910000/910200/ |p 4 | ||
| 998 | |g 1022150499 |a Hinz, Ulf |m 1022150499:Hinz, Ulf |d 910000 |d 910200 |e 910000PH1022150499 |e 910200PH1022150499 |k 0/910000/ |k 1/910000/910200/ |p 3 | ||
| 998 | |g 143006827 |a Hassenpflug, Matthias |m 143006827:Hassenpflug, Matthias |d 910000 |d 910200 |e 910000PH143006827 |e 910200PH143006827 |k 0/910000/ |k 1/910000/910200/ |p 2 | ||
| 998 | |g 103328145X |a Tjaden, Christin |m 103328145X:Tjaden, Christin |d 910000 |d 910200 |e 910000PT103328145X |e 910200PT103328145X |k 0/910000/ |k 1/910000/910200/ |p 1 |x j | ||
| 999 | |a KXP-PPN1684166802 |e 3556341794 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"person":[{"display":"Tjaden, Christin","given":"Christin","role":"aut","family":"Tjaden"},{"display":"Hassenpflug, Matthias","role":"aut","given":"Matthias","family":"Hassenpflug"},{"display":"Hinz, Ulf","family":"Hinz","role":"aut","given":"Ulf"},{"role":"aut","given":"Ulla","family":"Klaiber","display":"Klaiber, Ulla"},{"family":"Klauß","given":"Miriam","role":"aut","display":"Klauß, Miriam"},{"display":"Büchler, Markus W.","role":"aut","given":"Markus W.","family":"Büchler"},{"role":"aut","given":"Thilo","family":"Hackert","display":"Hackert, Thilo"}],"title":[{"title_sort":"Outcome and prognosis after pancreatectomy in patients with solid pseudopapillary neoplasms","title":"Outcome and prognosis after pancreatectomy in patients with solid pseudopapillary neoplasms"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"physDesc":[{"extent":"11 S."}],"language":["eng"],"id":{"eki":["1684166802"],"doi":["10.1016/j.pan.2019.06.008"]},"origin":[{"dateIssuedDisp":"14 June 2019","dateIssuedKey":"2019"}],"name":{"displayForm":["Christine Tjaden, Matthias Hassenpflug, Ulf Hinz, Ulla Klaiber, Miriam Klauss, Markus W. Büchler, Thilo Hackert"]},"recId":"1684166802","note":["Gesehen am 04.12.2019"],"relHost":[{"disp":"Outcome and prognosis after pancreatectomy in patients with solid pseudopapillary neoplasmsPancreatology","recId":"32764432X","part":{"year":"2019","issue":"5","text":"19(2019), 5, Seite 699-709","extent":"11","volume":"19","pages":"699-709"},"id":{"eki":["32764432X"],"issn":["1424-3911"],"zdb":["2043694-4"]},"origin":[{"publisher":"Elsevier ; Karger","dateIssuedKey":"2001","dateIssuedDisp":"2001-","publisherPlace":"Amsterdam ; Basel"}],"pubHistory":["1.2001 -"],"physDesc":[{"extent":"Online-Ressource"}],"language":["eng"],"type":{"media":"Online-Ressource","bibl":"periodical"},"note":["Gesehen am 09.01.2019"],"title":[{"title":"Pancreatology","subtitle":"official journal of the International Association of Pancreatology (IAP) and the European Pancreatic Club (EPC)","title_sort":"Pancreatology"}]}]} | ||
| SRT | |a TJADENCHRIOUTCOMEAND1420 | ||