Inflammation- and angiogenesis-related biomarkers are correlated with cancer-related fatigue in colorectal cancer patients: results from the ColoCare Study
Cancer-related fatigue is one of the most common side effects of colorectal cancer treatment and is affected by biomedical factors. We investigated the association of inflammation- and angiogenesis-related biomarkers with cancer-related fatigue. Pre-surgery (baseline) serum samples were obtained fro...
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| Hauptverfasser: | , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
24 April 2019
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| In: |
European journal of cancer care
Year: 2019, Jahrgang: 28, Heft: 4, Pages: 13055 |
| ISSN: | 1365-2354 |
| DOI: | 10.1111/ecc.13055 |
| Online-Zugang: | Verlag, Volltext: https://doi.org/10.1111/ecc.13055 Verlag, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/ecc.13055 
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| Verfasserangaben: | Caroline Himbert, Jennifer Ose, Tengda Lin, Christy A. Warby, Biljana Gigic, Karen Steindorf, Petra Schrotz‐King, Clare Abbenhardt‐Martin, Lin Zielske, Juergen Boehm, Cornelia M. Ulrich |
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| 245 | 1 | 0 | |a Inflammation- and angiogenesis-related biomarkers are correlated with cancer-related fatigue in colorectal cancer patients |b results from the ColoCare Study |c Caroline Himbert, Jennifer Ose, Tengda Lin, Christy A. Warby, Biljana Gigic, Karen Steindorf, Petra Schrotz‐King, Clare Abbenhardt‐Martin, Lin Zielske, Juergen Boehm, Cornelia M. Ulrich |
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| 520 | |a Cancer-related fatigue is one of the most common side effects of colorectal cancer treatment and is affected by biomedical factors. We investigated the association of inflammation- and angiogenesis-related biomarkers with cancer-related fatigue. Pre-surgery (baseline) serum samples were obtained from n = 236 newly diagnosed colorectal cancer patients. Meso Scale Discovery assays were performed to measure levels of biomarkers for inflammation and angiogenesis (CRP, SAA, IL-6, IL-8, MCP-1, sICAM-1, sVCAM-1, TNFα, VEGFA and VEGFD). Cancer-related fatigue was assessed with the EORTC QLQ-30 questionnaire at baseline and 6 and 12 months post-surgery. We tested associations using Spearman's partial correlations and logistic regression analyses, adjusting for age, sex and body mass index. sICAM-1 and VEGFD showed a significant positive correlation with cancer-related fatigue at baseline and 6-, and 12-month follow-up (sICAM-1: r = 0.19, p = 0.010; r = 0.24, p = 0.004; r = 0.25, p = 0.006; VEGFD: r = 0.20, p = 0.006; r = 0.15, p = 0.06; r = 0.23, p = 0.01 respectively). Biomarkers of inflammation and angiogenesis measured prior to surgery are associated with cancer-related fatigue in colorectal cancer patients throughout various time points. Our results suggest the involvement of overexpressed sICAM-1 and VEGFD in the development of fatigue. | ||
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