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Inflammation- and angiogenesis-related biomarkers are correlated with cancer-related fatigue in colorectal cancer patients: results from the ColoCare Study

Cancer-related fatigue is one of the most common side effects of colorectal cancer treatment and is affected by biomedical factors. We investigated the association of inflammation- and angiogenesis-related biomarkers with cancer-related fatigue. Pre-surgery (baseline) serum samples were obtained fro...

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Main Authors: Himbert, Caroline (Author) , Ose, Jennifer (Author) , Lin, Tengda (Author) , Warby, Christy A. (Author) , Gigić, Biljana (Author) , Steindorf, Karen (Author) , Schrotz-King, Petra (Author) , Abbenhardt-Martin, Clare (Author) , Zielske, Lin (Author) , Böhm, Jürgen (Author) , Ulrich, Cornelia (Author)
Format: Article (Journal)
Language:English
Published: 24 April 2019
In: European journal of cancer care
Year: 2019, Volume: 28, Issue: 4, Pages: 13055
ISSN:1365-2354
DOI:10.1111/ecc.13055
Online Access:Verlag, Volltext: https://doi.org/10.1111/ecc.13055
Verlag, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/ecc.13055
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Author Notes:Caroline Himbert, Jennifer Ose, Tengda Lin, Christy A. Warby, Biljana Gigic, Karen Steindorf, Petra Schrotz‐King, Clare Abbenhardt‐Martin, Lin Zielske, Juergen Boehm, Cornelia M. Ulrich
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Summary:Cancer-related fatigue is one of the most common side effects of colorectal cancer treatment and is affected by biomedical factors. We investigated the association of inflammation- and angiogenesis-related biomarkers with cancer-related fatigue. Pre-surgery (baseline) serum samples were obtained from n = 236 newly diagnosed colorectal cancer patients. Meso Scale Discovery assays were performed to measure levels of biomarkers for inflammation and angiogenesis (CRP, SAA, IL-6, IL-8, MCP-1, sICAM-1, sVCAM-1, TNFα, VEGFA and VEGFD). Cancer-related fatigue was assessed with the EORTC QLQ-30 questionnaire at baseline and 6 and 12 months post-surgery. We tested associations using Spearman's partial correlations and logistic regression analyses, adjusting for age, sex and body mass index. sICAM-1 and VEGFD showed a significant positive correlation with cancer-related fatigue at baseline and 6-, and 12-month follow-up (sICAM-1: r = 0.19, p = 0.010; r = 0.24, p = 0.004; r = 0.25, p = 0.006; VEGFD: r = 0.20, p = 0.006; r = 0.15, p = 0.06; r = 0.23, p = 0.01 respectively). Biomarkers of inflammation and angiogenesis measured prior to surgery are associated with cancer-related fatigue in colorectal cancer patients throughout various time points. Our results suggest the involvement of overexpressed sICAM-1 and VEGFD in the development of fatigue.
Item Description:Gesehen am 05.12.2019
Physical Description:Online Resource
ISSN:1365-2354
DOI:10.1111/ecc.13055

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