Genetic ablation of TASK-1 (tandem of P domains in a weak inward rectifying K+ channel-related acid-sensitive K+ channel-1) (K2P3.1) K+ channels suppresses atrial fibrillation and prevents electrical remodeling
Background:Despite an increasing understanding of atrial fibrillation (AF) pathophysiology, translation into mechanism-based treatment options is lacking. In atrial cardiomyocytes of patients with chronic AF, expression, and function of tandem of P domains in a weak inward rectifying TASK-1 (K+ chan...
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| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
September 13, 2019
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| In: |
Circulation. Arrhythmia and electrophysiology
Year: 2019, Volume: 12, Issue: 9, Pages: e007465 |
| ISSN: | 1941-3084 |
| DOI: | 10.1161/CIRCEP.119.007465 |
| Online Access: | Verlag, Volltext: https://doi.org/10.1161/CIRCEP.119.007465 Verlag: https://www.ahajournals.org/doi/10.1161/CIRCEP.119.007465 
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| Author Notes: | Constanze Schmidt, MD, Felix Wiedmann, MD, Christoph Beyersdorf, BS, Zhi-han Zhao, MSc, Ibrahim El-Battrawy, MD, Huan Lan, MD, Gabor Szabo, MD, Xin Li, MSc, Siegfried Lang, PhD, Sevil Korkmaz-Icöz, MD, Kleopatra Rapti, PhD, Andreas Jungmann, PhD, Antonius Ratte, MD, Oliver J. Müller, MD, Matthias Karck, MD, Gunnar Seemann, PhD, Ibrahim Akin, MD, Martin Borggrefe, MD, Xiao-Bo Zhou, MD, Hugo A. Katus, MD, Dierk Thomas, MD |
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