Immunohistochemical profiling of liver metastases and matched-pair analysis in patients with metastatic pancreatic ductal adenocarcinoma
Background - The purpose of the current study was to investigate the immunohistochemical (IHC) profile of liver metastases (LM) in patients with pancreatic ductal adenocarcinoma (PDAC). - Methods - Expression of 15 IHC markers in liver biopsies from 77 patients with PDAC, who were diagnosed between...
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| Hauptverfasser: | , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
14 September 2019
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| In: |
Pancreatology
Year: 2019, Jahrgang: 19, Heft: 7, Pages: 963-970 |
| ISSN: | 1424-3911 |
| DOI: | 10.1016/j.pan.2019.09.005 |
| Online-Zugang: | Verlag, Volltext: https://doi.org/10.1016/j.pan.2019.09.005 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S1424390319307264 
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| Verfasserangaben: | Thomas Held, Caroline S. Verbeke, Oliver Strobel, Wiktor Rutkowski, Christina Villard, Carlos Fernández Moro, Marco Del Chiaro, Markus Büchler, Rainer Heuchel, Matthias Löhr |
MARC
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| 245 | 1 | 0 | |a Immunohistochemical profiling of liver metastases and matched-pair analysis in patients with metastatic pancreatic ductal adenocarcinoma |c Thomas Held, Caroline S. Verbeke, Oliver Strobel, Wiktor Rutkowski, Christina Villard, Carlos Fernández Moro, Marco Del Chiaro, Markus Büchler, Rainer Heuchel, Matthias Löhr |
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| 520 | |a Background - The purpose of the current study was to investigate the immunohistochemical (IHC) profile of liver metastases (LM) in patients with pancreatic ductal adenocarcinoma (PDAC). - Methods - Expression of 15 IHC markers in liver biopsies from 77 patients with PDAC, who were diagnosed between 2010 and 2014, were evaluated. In a separate subgroup analysis (n=12), paired samples (LM and primary tumor) from the same patient were investigated for IHC profile differences. - Results - LM samples were classified as pancreatobiliary-type (PB-type) in 72 patients (93.5%), intestinal-type (INT-type) in four patients (5.2%), and squamous in one patient (1.3%). There was no significant difference in overall survival (OS) between LM of the PB-type or INT-type (p=0.097). In a multivariate analysis, age <70 years (p=0.047), absence of SMAD4 mutation (p=0.026), absence of CDX2 expression (p=0.003), and well to moderate differentiation were significant prognostic factors for better OS in patients with LM (p=0.031). Analysis of paired tissue samples from LM and the primary tumor revealed a difference in CDX2 (50% increase, p=0.125) and SMAD4 (33% loss of SMAD4, p=0.375). - Conclusions - CDX2 expression and SMAD4 mutation indicate a poor outcome in patients with LM of PDAC. Matched-pair analysis revealed differences in distinct IHC marker expression. | ||
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