Differential effects of Ang-2/VEGF-A inhibiting antibodies in combination with radio- or chemotherapy in glioma
Antiangiogenic strategies have not shown striking antitumor activities in the majority of glioma patients so far. It is unclear which antiangiogenic combination regimen with standard therapy is most effective. Therefore, we compared anti-VEGF-A, anti-Ang2, and bispecific anti-Ang-2/VEGF-A antibody t...
Gespeichert in:
| Hauptverfasser: | , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
6 March 2019
|
| In: |
Cancers
Year: 2019, Jahrgang: 11, Heft: 3 |
| ISSN: | 2072-6694 |
| DOI: | 10.3390/cancers11030314 |
| Online-Zugang: | Verlag, Volltext: https://doi.org/10.3390/cancers11030314 Verlag: https://www.mdpi.com/2072-6694/11/3/314 
|
| Verfasserangaben: | Gergely Solecki, Matthias Osswald, Daniel Weber, Malte Glock, Miriam Ratliff, Hans-Joachim Müller, Oliver Krieter, Yvonne Kienast, Wolfgang Wick and Frank Winkler |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1684405734 | ||
| 003 | DE-627 | ||
| 005 | 20230426073117.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 191205s2019 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.3390/cancers11030314 |2 doi | |
| 035 | |a (DE-627)1684405734 | ||
| 035 | |a (DE-599)KXP1684405734 | ||
| 035 | |a (OCoLC)1341280555 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Solecki, Gergely |e VerfasserIn |0 (DE-588)1139308556 |0 (DE-627)89706237X |0 (DE-576)493232974 |4 aut | |
| 245 | 1 | 0 | |a Differential effects of Ang-2/VEGF-A inhibiting antibodies in combination with radio- or chemotherapy in glioma |c Gergely Solecki, Matthias Osswald, Daniel Weber, Malte Glock, Miriam Ratliff, Hans-Joachim Müller, Oliver Krieter, Yvonne Kienast, Wolfgang Wick and Frank Winkler |
| 264 | 1 | |c 6 March 2019 | |
| 300 | |a 16 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 05.12.2019 | ||
| 520 | |a Antiangiogenic strategies have not shown striking antitumor activities in the majority of glioma patients so far. It is unclear which antiangiogenic combination regimen with standard therapy is most effective. Therefore, we compared anti-VEGF-A, anti-Ang2, and bispecific anti-Ang-2/VEGF-A antibody treatments, alone and in combination with radio- or temozolomide (TMZ) chemotherapy, in a malignant glioma model using multiparameter two-photon in vivo microscopy in mice. We demonstrate that anti-Ang-2/VEGF-A lead to the strongest vascular changes, including vascular normalization, both as monotherapy and when combined with chemotherapy. The latter was accompanied by the most effective chemotherapy-induced death of cancer cells and diminished tumor growth. This was most probably due to a better tumor distribution of the drug, decreased tumor cell motility, and decreased formation of resistance-associated tumor microtubes. Remarkably, all these parameters where reverted when radiotherapy was chosen as combination partner for anti-Ang-2/VEGF-A. In contrast, the best combination partner for radiotherapy was anti-VEGF-A. In conclusion, while TMZ chemotherapy benefits most from combination with anti-Ang-2/VEGF-A, radiotherapy does from anti-VEGF-A. The findings imply that uninformed combination regimens of antiangiogenic and cytotoxic therapies should be avoided. | ||
| 650 | 4 | |a Ang-2 | |
| 650 | 4 | |a antiangiogenic therapy | |
| 650 | 4 | |a in vivo imaging | |
| 650 | 4 | |a radio- and chemotherapy | |
| 650 | 4 | |a VEGF-A | |
| 700 | 1 | |a Osswald, Matthias |d 1982- |e VerfasserIn |0 (DE-588)139015620 |0 (DE-627)703181645 |0 (DE-576)309419069 |4 aut | |
| 700 | 1 | |a Weber, Daniel |d 1997- |e VerfasserIn |0 (DE-588)1201125995 |0 (DE-627)1684410231 |4 aut | |
| 700 | 1 | |a Glock, Malte |e VerfasserIn |0 (DE-588)1201126320 |0 (DE-627)1684410762 |4 aut | |
| 700 | 1 | |a Ratliff, Miriam |d 1979- |e VerfasserIn |0 (DE-588)1012081028 |0 (DE-627)660894602 |0 (DE-576)344899357 |4 aut | |
| 700 | 1 | |a Wick, Wolfgang |d 1970- |e VerfasserIn |0 (DE-588)120297736 |0 (DE-627)080586929 |0 (DE-576)186221320 |4 aut | |
| 700 | 1 | |a Winkler, Frank |d 1971- |e VerfasserIn |0 (DE-588)120794586 |0 (DE-627)704993104 |0 (DE-576)292388586 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Cancers |d Basel : MDPI, 2009 |g 11(2019,3) Artikel-Nummer 314, 16 Seiten |h Online-Ressource |w (DE-627)614095670 |w (DE-600)2527080-1 |w (DE-576)313958548 |x 2072-6694 |7 nnas |a Differential effects of Ang-2/VEGF-A inhibiting antibodies in combination with radio- or chemotherapy in glioma |
| 773 | 1 | 8 | |g volume:11 |g year:2019 |g number:3 |g extent:16 |a Differential effects of Ang-2/VEGF-A inhibiting antibodies in combination with radio- or chemotherapy in glioma |
| 856 | 4 | 0 | |u https://doi.org/10.3390/cancers11030314 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u https://www.mdpi.com/2072-6694/11/3/314 |x Verlag |
| 951 | |a AR | ||
| 992 | |a 20191205 | ||
| 993 | |a Article | ||
| 994 | |a 2019 | ||
| 998 | |g 120794586 |a Winkler, Frank |m 120794586:Winkler, Frank |d 910000 |d 911100 |e 910000PW120794586 |e 911100PW120794586 |k 0/910000/ |k 1/910000/911100/ |p 10 |y j | ||
| 998 | |g 120297736 |a Wick, Wolfgang |m 120297736:Wick, Wolfgang |d 910000 |d 911100 |e 910000PW120297736 |e 911100PW120297736 |k 0/910000/ |k 1/910000/911100/ |p 9 | ||
| 998 | |g 1012081028 |a Ratliff, Miriam |m 1012081028:Ratliff, Miriam |p 5 | ||
| 998 | |g 1201126320 |a Glock, Malte |m 1201126320:Glock, Malte |p 4 | ||
| 998 | |g 1201125995 |a Weber, Daniel |m 1201125995:Weber, Daniel |p 3 | ||
| 998 | |g 139015620 |a Osswald, Matthias |m 139015620:Osswald, Matthias |d 910000 |d 911100 |e 910000PO139015620 |e 911100PO139015620 |k 0/910000/ |k 1/910000/911100/ |p 2 | ||
| 998 | |g 1139308556 |a Solecki, Gergely |m 1139308556:Solecki, Gergely |p 1 |x j | ||
| 999 | |a KXP-PPN1684405734 |e 3557040127 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"name":{"displayForm":["Gergely Solecki, Matthias Osswald, Daniel Weber, Malte Glock, Miriam Ratliff, Hans-Joachim Müller, Oliver Krieter, Yvonne Kienast, Wolfgang Wick and Frank Winkler"]},"id":{"eki":["1684405734"],"doi":["10.3390/cancers11030314"]},"origin":[{"dateIssuedKey":"2019","dateIssuedDisp":"6 March 2019"}],"person":[{"display":"Solecki, Gergely","given":"Gergely","role":"aut","family":"Solecki"},{"role":"aut","given":"Matthias","family":"Osswald","display":"Osswald, Matthias"},{"role":"aut","given":"Daniel","family":"Weber","display":"Weber, Daniel"},{"role":"aut","given":"Malte","family":"Glock","display":"Glock, Malte"},{"family":"Ratliff","given":"Miriam","role":"aut","display":"Ratliff, Miriam"},{"given":"Wolfgang","role":"aut","family":"Wick","display":"Wick, Wolfgang"},{"family":"Winkler","given":"Frank","role":"aut","display":"Winkler, Frank"}],"relHost":[{"title":[{"title":"Cancers","title_sort":"Cancers"}],"language":["eng"],"type":{"bibl":"periodical","media":"Online-Ressource"},"note":["Gesehen am 27.05.2020"],"origin":[{"dateIssuedKey":"2009","publisherPlace":"Basel","dateIssuedDisp":"2009-","publisher":"MDPI"}],"disp":"Differential effects of Ang-2/VEGF-A inhibiting antibodies in combination with radio- or chemotherapy in gliomaCancers","recId":"614095670","physDesc":[{"extent":"Online-Ressource"}],"id":{"eki":["614095670"],"issn":["2072-6694"],"zdb":["2527080-1"]},"part":{"extent":"16","text":"11(2019,3) Artikel-Nummer 314, 16 Seiten","volume":"11","issue":"3","year":"2019"},"name":{"displayForm":["Molecular Diversity Preservation International (MDPI)"]},"pubHistory":["1.2009 -"]}],"language":["eng"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"note":["Gesehen am 05.12.2019"],"title":[{"title":"Differential effects of Ang-2/VEGF-A inhibiting antibodies in combination with radio- or chemotherapy in glioma","title_sort":"Differential effects of Ang-2/VEGF-A inhibiting antibodies in combination with radio- or chemotherapy in glioma"}],"physDesc":[{"extent":"16 S."}],"recId":"1684405734"} | ||
| SRT | |a SOLECKIGERDIFFERENTI6201 | ||