The lipid-droplet-associated protein ABHD5 protects the heart through proteolysis of HDAC4
Known as a regulator of lipolysis, ABHD5 is found to also act as a serine protease that cleaves HDAC4 in response to catecholaminergic stimulation, thus resulting in the formation of a polypeptide that protects against metabolic-stress-induced heart failure.
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| Hauptverfasser: | , , , , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
15 November 2019
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| In: |
Nature metabolism
Year: 2019, Jahrgang: 1, Heft: 11, Pages: 1157-1167 |
| ISSN: | 2522-5812 |
| DOI: | 10.1038/s42255-019-0138-4 |
| Online-Zugang: | Resolving-System, Volltext: https://doi.org/10.1038/s42255-019-0138-4 Verlag: https://www.nature.com/articles/s42255-019-0138-4 
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| Verfasserangaben: | Zegeye H. Jebessa, Kumar D. Shanmukha, Matthias Dewenter, Lorenz H. Lehmann, Chang Xu, Friederike Schreiter, Dominik Siede, Xue-Min Gong, Barbara C. Worst, Giuseppina Federico, Sven W. Sauer, Tamas Fischer, Lisa Wechselberger, Oliver J. Müller, Samuel Sossalla, Christoph Dieterich, Patrick Most, Herrmann-Josef Gröne, Cedric Moro, Monika Oberer, Guenter Haemmerle, Hugo A. Katus, Jens Tyedmers and Johannes Backs |
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