Helium ions for radiotherapy?: Physical and biological verifications of a novel treatment modality
Purpose: Modern facilities for actively scanned ion beam radiotherapy allow in principle the use of helium beams, which could present specific advantages, especially for pediatric tumors. In order to assess the potential use of these beams for radiotherapy, i.e., to create realistic treatment plans,...
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| Main Authors: | , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
30 March 2016
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| In: |
Medical physics
Year: 2016, Volume: 43, Issue: 4, Pages: 1995-2004 |
| ISSN: | 2473-4209 |
| DOI: | 10.1118/1.4944593 |
| Online Access: | Verlag, Volltext: https://doi.org/10.1118/1.4944593 Verlag, Volltext: https://aapm.onlinelibrary.wiley.com/doi/abs/10.1118/1.4944593 
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| Author Notes: | Michael Krämer, Emanuele Scifoni, Christoph Schuy, Marta Rovituso, Walter Tinganelli, Andreas Maier, Robert Kaderka, Wilma Kraft‐Weyrather, Stephan Brons, Thomas Tessonnier, Katia Parodi, Marco Durante |
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| 245 | 1 | 0 | |a Helium ions for radiotherapy? |b Physical and biological verifications of a novel treatment modality |c Michael Krämer, Emanuele Scifoni, Christoph Schuy, Marta Rovituso, Walter Tinganelli, Andreas Maier, Robert Kaderka, Wilma Kraft‐Weyrather, Stephan Brons, Thomas Tessonnier, Katia Parodi, Marco Durante |
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| 520 | |a Purpose: Modern facilities for actively scanned ion beam radiotherapy allow in principle the use of helium beams, which could present specific advantages, especially for pediatric tumors. In order to assess the potential use of these beams for radiotherapy, i.e., to create realistic treatment plans, the authors set up a dedicated 4He beam model, providing base data for their treatment planning system TRiP98, and they have reported that in this work together with its physical and biological validations. Methods: A semiempirical beam model for the physical depth dose deposition and the production of nuclear fragments was developed and introduced in TRiP98. For the biological effect calculations the last version of the local effect model was used. The model predictions were experimentally verified at the HIT facility. The primary beam attenuation and the characteristics of secondary charged particles at various depth in water were investigated using 4He ion beams of 200 MeV/u. The nuclear charge of secondary fragments was identified using a ΔE/E telescope. 3D absorbed dose distributions were measured with pin point ionization chambers and the biological dosimetry experiments were realized irradiating a Chinese hamster ovary cells stack arranged in an extended target. Results: The few experimental data available on basic physical processes are reproduced by their beam model. The experimental verification of absorbed dose distributions in extended target volumes yields an overall agreement, with a slight underestimation of the lateral spread. Cell survival along a 4 cm extended target is reproduced with remarkable accuracy. Conclusions: The authors presented a simple simulation model for therapeutical 4He beams which they introduced in TRiP98, and which is validated experimentally by means of physical and biological dosimetries. Thus, it is now possible to perform detailed treatment planning studies with 4He beams, either exclusively or in combination with other ion modalities. | ||
| 650 | 4 | |a Alpha particles | |
| 650 | 4 | |a Carbon | |
| 650 | 4 | |a Chemical reaction cross sections | |
| 650 | 4 | |a Computer modeling | |
| 650 | 4 | |a dosimetry | |
| 650 | 4 | |a Dosimetry | |
| 650 | 4 | |a Dosimetry/exposure assessment | |
| 650 | 4 | |a helium | |
| 650 | 4 | |a helium ions | |
| 650 | 4 | |a Helium-4 | |
| 650 | 4 | |a including brachytherapy | |
| 650 | 4 | |a ion beam radiotherapy | |
| 650 | 4 | |a Ion beams | |
| 650 | 4 | |a ionisation chambers | |
| 650 | 4 | |a paediatrics | |
| 650 | 4 | |a Protons | |
| 650 | 4 | |a radiation therapy | |
| 650 | 4 | |a Radiation therapy | |
| 650 | 4 | |a Scintigraphy | |
| 650 | 4 | |a Therapeutic applications | |
| 650 | 4 | |a treatment planning system | |
| 650 | 4 | |a tumours | |
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