Cover Image

Copy number load predicts outcome of metastatic colorectal cancer patients receiving bevacizumab combination therapy

Increased copy number alterations, indicative of chromosomal instability, is associated with poor cancer outcome. Here, metastatic colorectal cancer patients displaying intermediate-high CIN associate with improved outcome following chemotherapy and bevacizumab treatment, suggesting CIN as a predict...

Full description

Saved in:
Bibliographic Details
Main Authors: Smeets, Dominiek (Author) , Miller, Ian S. (Author) , O’Connor, Darran P. (Author) , Das, Sudipto (Author) , Moran, Bruce (Author) , Boeckx, Bram (Author) , Gaiser, Timo (Author) , Betge, Johannes (Author) , Barat, Ana (Author) , Klinger, Rut (Author) , Grieken, Nicole C. T. van (Author) , Cremolini, Chiara (Author) , Prenen, Hans (Author) , Mazzone, Massimiliano (Author) , Depreeuw, Jeroen (Author) , Bacon, Orna (Author) , Fender, Bozena (Author) , Brady, Joseph (Author) , Hennessy, Bryan T. (Author) , McNamara, Deborah A. (Author) , Kay, Elaine (Author) , Verheul, Henk M. (Author) , Maarten, Neerincx (Author) , Gallagher, William M. (Author) , Murphy, Verena (Author) , Prehn, Jochen H. M. (Author) , Koopman, Miriam (Author) , Punt, Cornelis J. A. (Author) , Loupakis, Fotios (Author) , Ebert, Matthias P. A. (Author) , Ylstra, Bauke (Author) , Lambrechts, Diether (Author) , Byrne, Annette T. (Author)
Format: Article (Journal)
Language:English
Published: 05 October 2018
In: Nature Communications
Year: 2018, Volume: 9, Pages: 1-16
ISSN:2041-1723
DOI:10.1038/s41467-018-06567-6
Online Access:Verlag, Volltext: http://dx.doi.org/10.1038/s41467-018-06567-6
Verlag, Volltext: https://www.nature.com/articles/s41467-018-06567-6
Get full text
Author Notes:Dominiek Smeets et al.

MARC

LEADER 00000caa a2200000 c 4500
001 168546243X
003 DE-627
005 20240617092958.0
007 cr uuu---uuuuu
008 191213s2018 xx |||||o 00| ||eng c
024 7 |a 10.1038/s41467-018-06567-6  |2 doi 
035 |a (DE-627)168546243X 
035 |a (DE-599)KXP168546243X 
035 |a (OCoLC)1341280908 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Smeets, Dominiek  |e VerfasserIn  |0 (DE-588)1201576075  |0 (DE-627)168546338X  |4 aut 
245 1 0 |a Copy number load predicts outcome of metastatic colorectal cancer patients receiving bevacizumab combination therapy  |c Dominiek Smeets et al. 
264 1 |c 05 October 2018 
300 |a 16 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 13.12.2019 
520 |a Increased copy number alterations, indicative of chromosomal instability, is associated with poor cancer outcome. Here, metastatic colorectal cancer patients displaying intermediate-high CIN associate with improved outcome following chemotherapy and bevacizumab treatment, suggesting CIN as a predictive biomarker. 
700 1 |a Miller, Ian S.  |e VerfasserIn  |4 aut 
700 1 |a O’Connor, Darran P.  |e VerfasserIn  |4 aut 
700 1 |a Das, Sudipto  |e VerfasserIn  |4 aut 
700 1 |a Moran, Bruce  |e VerfasserIn  |4 aut 
700 1 |a Boeckx, Bram  |e VerfasserIn  |4 aut 
700 1 |a Gaiser, Timo  |d 1975-  |e VerfasserIn  |0 (DE-588)1030402280  |0 (DE-627)735221685  |0 (DE-576)378226533  |4 aut 
700 1 |a Betge, Johannes  |d 1986-  |e VerfasserIn  |0 (DE-588)108257421X  |0 (DE-627)847674347  |0 (DE-576)455525021  |4 aut 
700 1 |a Barat, Ana  |e VerfasserIn  |4 aut 
700 1 |a Klinger, Rut  |e VerfasserIn  |4 aut 
700 1 |a Grieken, Nicole C. T. van  |e VerfasserIn  |4 aut 
700 1 |a Cremolini, Chiara  |e VerfasserIn  |4 aut 
700 1 |a Prenen, Hans  |e VerfasserIn  |4 aut 
700 1 |a Mazzone, Massimiliano  |e VerfasserIn  |4 aut 
700 1 |a Depreeuw, Jeroen  |e VerfasserIn  |4 aut 
700 1 |a Bacon, Orna  |e VerfasserIn  |4 aut 
700 1 |a Fender, Bozena  |e VerfasserIn  |4 aut 
700 1 |a Brady, Joseph  |e VerfasserIn  |4 aut 
700 1 |a Hennessy, Bryan T.  |e VerfasserIn  |4 aut 
700 1 |a McNamara, Deborah A.  |e VerfasserIn  |4 aut 
700 1 |a Kay, Elaine  |e VerfasserIn  |4 aut 
700 1 |a Verheul, Henk M.  |e VerfasserIn  |4 aut 
700 1 |a Maarten, Neerincx  |e VerfasserIn  |4 aut 
700 1 |a Gallagher, William M.  |e VerfasserIn  |4 aut 
700 1 |a Murphy, Verena  |e VerfasserIn  |4 aut 
700 1 |a Prehn, Jochen H. M.  |e VerfasserIn  |4 aut 
700 1 |a Koopman, Miriam  |e VerfasserIn  |4 aut 
700 1 |a Punt, Cornelis J. A.  |e VerfasserIn  |4 aut 
700 1 |a Loupakis, Fotios  |e VerfasserIn  |4 aut 
700 1 |a Ebert, Matthias P. A.  |e VerfasserIn  |4 aut 
700 1 |a Ylstra, Bauke  |e VerfasserIn  |4 aut 
700 1 |a Lambrechts, Diether  |e VerfasserIn  |4 aut 
700 1 |a Byrne, Annette T.  |e VerfasserIn  |4 aut 
773 0 8 |i Enthalten in  |t Nature Communications  |d [London] : Springer Nature, 2010  |g 9(2018), Artikel-ID 4112, Seite 1-16  |h Online-Ressource  |w (DE-627)626457688  |w (DE-600)2553671-0  |w (DE-576)331555905  |x 2041-1723  |7 nnas  |a Copy number load predicts outcome of metastatic colorectal cancer patients receiving bevacizumab combination therapy 
773 1 8 |g volume:9  |g year:2018  |g elocationid:4112  |g pages:1-16  |g extent:16  |a Copy number load predicts outcome of metastatic colorectal cancer patients receiving bevacizumab combination therapy 
856 4 0 |u http://dx.doi.org/10.1038/s41467-018-06567-6  |x Verlag  |x Resolving-System  |3 Volltext 
856 4 0 |u https://www.nature.com/articles/s41467-018-06567-6  |x Verlag  |3 Volltext 
951 |a AR 
992 |a 20191213 
993 |a Article 
994 |a 2018 
998 |g 108257421X  |a Betge, Johannes  |m 108257421X:Betge, Johannes  |d 60000  |d 61100  |e 60000PB108257421X  |e 61100PB108257421X  |k 0/60000/  |k 1/60000/61100/  |p 8 
998 |g 1030402280  |a Gaiser, Timo  |m 1030402280:Gaiser, Timo  |d 60000  |d 63400  |e 60000PG1030402280  |e 63400PG1030402280  |k 0/60000/  |k 1/60000/63400/  |p 7 
999 |a KXP-PPN168546243X  |e 356457106X 
BIB |a Y 
SER |a journal 
JSO |a {"name":{"displayForm":["Dominiek Smeets et al."]},"recId":"168546243X","id":{"eki":["168546243X"],"doi":["10.1038/s41467-018-06567-6"]},"origin":[{"dateIssuedKey":"2018","dateIssuedDisp":"05 October 2018"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"language":["eng"],"physDesc":[{"extent":"16 S."}],"person":[{"given":"Dominiek","role":"aut","family":"Smeets","display":"Smeets, Dominiek"},{"display":"Miller, Ian S.","family":"Miller","role":"aut","given":"Ian S."},{"role":"aut","given":"Darran P.","family":"O’Connor","display":"O’Connor, Darran P."},{"display":"Das, Sudipto","role":"aut","given":"Sudipto","family":"Das"},{"family":"Moran","role":"aut","given":"Bruce","display":"Moran, Bruce"},{"display":"Boeckx, Bram","family":"Boeckx","role":"aut","given":"Bram"},{"display":"Gaiser, Timo","role":"aut","given":"Timo","family":"Gaiser"},{"role":"aut","given":"Johannes","family":"Betge","display":"Betge, Johannes"},{"role":"aut","given":"Ana","family":"Barat","display":"Barat, Ana"},{"family":"Klinger","role":"aut","given":"Rut","display":"Klinger, Rut"},{"family":"Grieken","role":"aut","given":"Nicole C. T. van","display":"Grieken, Nicole C. T. van"},{"role":"aut","given":"Chiara","family":"Cremolini","display":"Cremolini, Chiara"},{"display":"Prenen, Hans","family":"Prenen","given":"Hans","role":"aut"},{"family":"Mazzone","role":"aut","given":"Massimiliano","display":"Mazzone, Massimiliano"},{"family":"Depreeuw","role":"aut","given":"Jeroen","display":"Depreeuw, Jeroen"},{"display":"Bacon, Orna","family":"Bacon","role":"aut","given":"Orna"},{"given":"Bozena","role":"aut","family":"Fender","display":"Fender, Bozena"},{"given":"Joseph","role":"aut","family":"Brady","display":"Brady, Joseph"},{"display":"Hennessy, Bryan T.","given":"Bryan T.","role":"aut","family":"Hennessy"},{"display":"McNamara, Deborah A.","role":"aut","given":"Deborah A.","family":"McNamara"},{"display":"Kay, Elaine","given":"Elaine","role":"aut","family":"Kay"},{"family":"Verheul","role":"aut","given":"Henk M.","display":"Verheul, Henk M."},{"display":"Maarten, Neerincx","family":"Maarten","role":"aut","given":"Neerincx"},{"display":"Gallagher, William M.","given":"William M.","role":"aut","family":"Gallagher"},{"family":"Murphy","given":"Verena","role":"aut","display":"Murphy, Verena"},{"family":"Prehn","given":"Jochen H. M.","role":"aut","display":"Prehn, Jochen H. M."},{"display":"Koopman, Miriam","family":"Koopman","given":"Miriam","role":"aut"},{"role":"aut","given":"Cornelis J. A.","family":"Punt","display":"Punt, Cornelis J. A."},{"family":"Loupakis","role":"aut","given":"Fotios","display":"Loupakis, Fotios"},{"family":"Ebert","role":"aut","given":"Matthias P. A.","display":"Ebert, Matthias P. A."},{"family":"Ylstra","role":"aut","given":"Bauke","display":"Ylstra, Bauke"},{"display":"Lambrechts, Diether","role":"aut","given":"Diether","family":"Lambrechts"},{"display":"Byrne, Annette T.","family":"Byrne","given":"Annette T.","role":"aut"}],"title":[{"title_sort":"Copy number load predicts outcome of metastatic colorectal cancer patients receiving bevacizumab combination therapy","title":"Copy number load predicts outcome of metastatic colorectal cancer patients receiving bevacizumab combination therapy"}],"relHost":[{"language":["eng"],"pubHistory":["2010-"],"physDesc":[{"extent":"Online-Ressource"}],"note":["Gesehen am 13.06.24"],"type":{"bibl":"periodical","media":"Online-Ressource"},"title":[{"title":"Nature Communications","title_sort":"Nature Communications"}],"disp":"Copy number load predicts outcome of metastatic colorectal cancer patients receiving bevacizumab combination therapyNature Communications","recId":"626457688","part":{"text":"9(2018), Artikel-ID 4112, Seite 1-16","extent":"16","pages":"1-16","volume":"9","year":"2018"},"origin":[{"publisherPlace":"[London] ; [London]","publisher":"Springer Nature ; Nature Publishing Group UK","dateIssuedDisp":"[2010]-"}],"id":{"issn":["2041-1723"],"zdb":["2553671-0"],"eki":["626457688"]}}],"note":["Gesehen am 13.12.2019"]} 
SRT |a SMEETSDOMICOPYNUMBER0520 

Similar Items