miR-339-3p is a tumor suppressor in melanoma
Determinants of invasion and metastasis in cancer remain of great interest to define. Here, we report the definition of miR-339-3p as a novel tumor suppressive microRNA that blocks melanoma cell invasion without affecting cell survival. miR-339-3p was identified by a comprehensive functional screen...
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| Hauptverfasser: | , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
April 15, 2016
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| In: |
Cancer research
Year: 2016, Jahrgang: 76, Heft: 12, Pages: 3562-3571 |
| ISSN: | 1538-7445 |
| DOI: | 10.1158/0008-5472.CAN-15-2932 |
| Online-Zugang: | Verlag, Volltext: https://doi.org/10.1158/0008-5472.CAN-15-2932 Verlag, Volltext: https://cancerres.aacrjournals.org/content/76/12/3562 
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| Verfasserangaben: | Claudia E.M. Weber, Chonglin Luo, Agnes Hotz-Wagenblatt, Adriane Gardyan, Theresa Kordaß, Tim Holland-Letz, Wolfram Osen, and Stefan B. Eichmüller |
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| 520 | |a Determinants of invasion and metastasis in cancer remain of great interest to define. Here, we report the definition of miR-339-3p as a novel tumor suppressive microRNA that blocks melanoma cell invasion without affecting cell survival. miR-339-3p was identified by a comprehensive functional screen of a human miRNA mimetic library in a cell-based assay for invasion by the melanoma cell line A375. miR-339-3p was determined as a strong inhibitor of invasion differentially expressed in melanoma cells and healthy melanocytes. MCL1 was defined as a target for downregulation by miR-339-3p, functioning through direct interaction with the 3′ untranslated region of MCL1 mRNA. Blocking miR-339-3p by an antagomiR was sufficient to increase melanoma cell invasion, an effect that could be phenocopied by RNAi-mediated silencing of MCL1. In vivo studies established that miR-339-3p overexpression was sufficient to decrease lung colonization by A375 melanoma cells in NSG mice, relative to control cells. Overall, our results defined miR-339-3p as a melanoma tumor suppressor, the levels of which contributes to invasive aggressiveness. | ||
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