Autoimmune and immunogenetic profile of patients with optic neuritis in a population-based cohort
Background: Optic neuritis (ON) is an inflammatory optic neuropathy, where the genetic and autoimmune dependency remains poorly characterized. Objective: To investigate autoimmune and immunogenetic aspects of ON. Method: In a prospective population-based cohort 51 patients with ON were included. At...
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| Hauptverfasser: | , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
7 March 2018
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| In: |
Multiple Sclerosis and Related Disorders
Year: 2018, Jahrgang: 21, Pages: 97-102 |
| ISSN: | 2211-0356 |
| DOI: | 10.1016/j.msard.2018.03.003 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1016/j.msard.2018.03.003 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S2211034818300890 
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| Verfasserangaben: | K. Soelberg, A.C. Nilsson, C. Nielsen, S. Jarius, M. Reindl, B. Wildemann, S.T. Lillevang, N. Asgari |
MARC
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| 245 | 1 | 0 | |a Autoimmune and immunogenetic profile of patients with optic neuritis in a population-based cohort |c K. Soelberg, A.C. Nilsson, C. Nielsen, S. Jarius, M. Reindl, B. Wildemann, S.T. Lillevang, N. Asgari |
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| 520 | |a Background: Optic neuritis (ON) is an inflammatory optic neuropathy, where the genetic and autoimmune dependency remains poorly characterized. Objective: To investigate autoimmune and immunogenetic aspects of ON. Method: In a prospective population-based cohort 51 patients with ON were included. At follow up 20 patients had progressed to multiple sclerosis (MS-ON). All patients were screened for neuronal and systemic autoantibodies. HLA genotypes and allele and genotype frequencies of the PTPN22 C1858T and the PD-1.3 single-nucleotide polymorphisms (SNPs) were determined and compared to a cohort of Danish blood donors, acting as healthy controls. Results: Median follow-up was 366 days (301−430) for MS-ON patients and 375 (range 50-436) for isolated ON (ION). Autoantibodies against myelin oligodendrocyte glycoprotein (MOG-IgG), were positive in two patients, no patients had anti-aquaporin-4 antibodies. Coexisting neural autoantibodies were detected in two patients and in 12 patients other systemic autoantibodies were found. Four (8%) had other autoimmune disorders. A family history of autoimmunity was observed in 12 (24%) and of demyelinating disease in six patients (12%). In MS-ON patients the frequencies of HLA-DQB1*06:02 and HLA-DRB1*15:01 tended to be higher compared to controls (p=0.08). Stratification of patients with presence of oligoclonal bands (OCB) showed an association to the HLA-DQB1*06:02-HLA-DRB1*15:01 haplotype in ION (HLA-DQB1*06:02 and HLA-DRB1*15:01 (p=0.03)), and in MS-ON patients (HLA-DQB1*06:02 and HLA-DRB1*15:01 (p=0.03)). No significant associations to PTPN22 1858C/T or PD-1.3G/A were found in any group comparison. Conclusions: ON patients had a general susceptibility to autoimmunity and two were MOG-IgG positive. HLA-DQB1*06:02 and HLA-DRB1*15:01 were associated with the presence of OCB in ON patients. | ||
| 650 | 4 | |a Genetics | |
| 650 | 4 | |a Immunology | |
| 650 | 4 | |a Multiple sclerosis | |
| 650 | 4 | |a Optic neuritis | |
| 700 | 1 | |a Nilsson, A. C. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Nielsen, C. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Jarius, Sven |e VerfasserIn |0 (DE-588)1054615918 |0 (DE-627)791654818 |0 (DE-576)410367478 |4 aut | |
| 700 | 1 | |a Reindl, M. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Wildemann, Brigitte |e VerfasserIn |0 (DE-588)110203844 |0 (DE-627)510150004 |0 (DE-576)171831330 |4 aut | |
| 700 | 1 | |a Lillevang, S. T. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Asgari, N. |e VerfasserIn |4 aut | |
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