Simple and robust polymer-based sensor for rapid cancer detection using serum
We report a polymer-based sensor that rapidly detects cancer based on changes in serum protein levels. Using three ratiometric fluorescence outputs, this simple system identifies early stage and metastatic lung cancer with a high level of accuracy exceeding many biomarker-based assays, making it an...
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| Hauptverfasser: | , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2019
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| In: |
Chemical communications
Year: 2019, Jahrgang: 55, Heft: 76, Pages: 11458-11461 |
| ISSN: | 1364-548X |
| DOI: | 10.1039/c9cc04854e |
| Online-Zugang: | Verlag, Volltext: https://doi.org/10.1039/c9cc04854e
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| Verfasserangaben: | Ngoc D.B. Le, Arvind K. Singla, Yingying Geng, Jinsong Han, Kai Seehafer, Gyan Prakash, Daniel F. Moyano, Charlene M. Downey, Michael J. Monument, Doha Itani, Uwe H.F. Bunz, Frank R. Jirik and Vincent M. Rotello |
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| 520 | |a We report a polymer-based sensor that rapidly detects cancer based on changes in serum protein levels. Using three ratiometric fluorescence outputs, this simple system identifies early stage and metastatic lung cancer with a high level of accuracy exceeding many biomarker-based assays, making it an attractive strategy for point-of-care testing. | ||
| 650 | 4 | |a Animals | |
| 650 | 4 | |a Biomarkers, Tumor | |
| 650 | 4 | |a Blood Proteins | |
| 650 | 4 | |a Fluorescence | |
| 650 | 4 | |a Fluorescent Dyes | |
| 650 | 4 | |a Humans | |
| 650 | 4 | |a Lung Neoplasms | |
| 650 | 4 | |a Mice | |
| 650 | 4 | |a Mice, Transgenic | |
| 650 | 4 | |a Molecular Structure | |
| 650 | 4 | |a Neoplasms, Experimental | |
| 650 | 4 | |a Point-of-Care Testing | |
| 650 | 4 | |a Polymers | |
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| 700 | 1 | |a Moyano, Daniel F. |e VerfasserIn |4 aut | |
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