Glochidion zeylanicum leaf extracts exhibit lifespan extending and oxidative stress resistance properties in Caenorhabditis elegans via DAF-16/FoxO and SKN-1/Nrf-2 signaling pathways
Background - Glochidion zeylanicum (GZ), a common plant in Thailand and Eastern Asia, is rich in antioxidants. However, the possible anti-aging and oxidative stress resistance properties of GZ leaf extracts (hexane and methanol extracts) have not been reported. - Purpose - We aimed to provide the fi...
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
31 July 2019
|
| In: |
Phytomedicine
Year: 2019, Jahrgang: 64, Pages: 153061 |
| ISSN: | 1618-095X |
| DOI: | 10.1016/j.phymed.2019.153061 |
| Online-Zugang: | Verlag, Volltext: https://doi.org/10.1016/j.phymed.2019.153061 Verlag: http://www.sciencedirect.com/science/article/pii/S0944711319302272 
|
| Verfasserangaben: | Chatrawee Duangjan, Panthakarn Rangsinth, Xiaojie Gu, Shaoxiong Zhang, Michael Wink, Tewin Tencomnao |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1686665172 | ||
| 003 | DE-627 | ||
| 005 | 20230428080217.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 200108s2019 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.phymed.2019.153061 |2 doi | |
| 035 | |a (DE-627)1686665172 | ||
| 035 | |a (DE-599)KXP1686665172 | ||
| 035 | |a (OCoLC)1341297463 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Duangjan, Chatrawee |e VerfasserIn |0 (DE-588)1202522599 |0 (DE-627)1686665113 |4 aut | |
| 245 | 1 | 0 | |a Glochidion zeylanicum leaf extracts exhibit lifespan extending and oxidative stress resistance properties in Caenorhabditis elegans via DAF-16/FoxO and SKN-1/Nrf-2 signaling pathways |c Chatrawee Duangjan, Panthakarn Rangsinth, Xiaojie Gu, Shaoxiong Zhang, Michael Wink, Tewin Tencomnao |
| 264 | 1 | |c 31 July 2019 | |
| 300 | |a 8 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Available online 31 July 2019 | ||
| 500 | |a Gesehen am 08.01.2020 | ||
| 520 | |a Background - Glochidion zeylanicum (GZ), a common plant in Thailand and Eastern Asia, is rich in antioxidants. However, the possible anti-aging and oxidative stress resistance properties of GZ leaf extracts (hexane and methanol extracts) have not been reported. - Purpose - We aimed to provide the first science-based evidence of the beneficial effects of GZ on anti-aging and oxidative stress resistance in the Caenorhabditis elegans model. - Methods - The phytochemical composition of the hexane and methanol extracts were analyzed using GLC-MS and LC-MS. Fingerprinting analysis of the extract was performed by RP-HPLC. We determined total phenolics, flavonoids, and antioxidant properties via DPPH and ABTS assays. Oxidative stress resistance, anti-aging and lifespan were studied in C. elegans treated with leaf extracts. - Results - GZ leaf extracts protected the worms against oxidative stress and attenuated ROS accumulation. The expression of stress-response genes, such as SOD-3, and GST-4 were up-regulated, whereas HSP-16.2 was down-regulated after GZ treatment. The oxidative stress resistance properties of GZ possibly involved the DAF-16/FoxO and SKN-1/Nrf-2 transcription factors. GZ leaf extracts improved pharyngeal pumping function and autofluorescent pigment attenuation suggesting anti-aging properties. GZ leaf extracts modulated the lifespan extension in C. elegans. - Conclusion - This study reports novel anti-aging and antioxidant activities of GZ leaf extracts, suggesting a novel bioactivity for a medicinally important plant and supplementary drug against oxidative stress. | ||
| 650 | 4 | |a Aging | |
| 650 | 4 | |a Antioxidants | |
| 650 | 4 | |a DAF-16/FoxO | |
| 650 | 4 | |a SKN-1/Nrf2 | |
| 700 | 1 | |a Wink, Michael |d 1951- |e VerfasserIn |0 (DE-588)124618146 |0 (DE-627)363448519 |0 (DE-576)164659390 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Phytomedicine |d München [u.a.] : Elsevier, 1994 |g 64(2019) Artikel-Nummer 153061, 8 Seiten |h Online-Ressource |w (DE-627)325793352 |w (DE-600)2040195-4 |w (DE-576)116691972 |x 1618-095X |7 nnas |a Glochidion zeylanicum leaf extracts exhibit lifespan extending and oxidative stress resistance properties in Caenorhabditis elegans via DAF-16/FoxO and SKN-1/Nrf-2 signaling pathways |
| 773 | 1 | 8 | |g volume:64 |g year:2019 |g pages:153061 |g extent:8 |a Glochidion zeylanicum leaf extracts exhibit lifespan extending and oxidative stress resistance properties in Caenorhabditis elegans via DAF-16/FoxO and SKN-1/Nrf-2 signaling pathways |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.phymed.2019.153061 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u http://www.sciencedirect.com/science/article/pii/S0944711319302272 |x Verlag |
| 951 | |a AR | ||
| 992 | |a 20200108 | ||
| 993 | |a Article | ||
| 994 | |a 2019 | ||
| 998 | |g 124618146 |a Wink, Michael |m 124618146:Wink, Michael |d 160000 |d 160100 |e 160000PW124618146 |e 160100PW124618146 |k 0/160000/ |k 1/160000/160100/ |p 5 | ||
| 999 | |a KXP-PPN1686665172 |e 3573310230 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"relHost":[{"pubHistory":["1.1994/95 -"],"type":{"media":"Online-Ressource","bibl":"periodical"},"language":["eng"],"disp":"Glochidion zeylanicum leaf extracts exhibit lifespan extending and oxidative stress resistance properties in Caenorhabditis elegans via DAF-16/FoxO and SKN-1/Nrf-2 signaling pathwaysPhytomedicine","recId":"325793352","note":["Fortsetzung der Druckausgabe","Gesehen am 13.06.2023"],"id":{"zdb":["2040195-4"],"issn":["1618-095X"],"eki":["325793352"]},"part":{"pages":"153061","extent":"8","year":"2019","volume":"64","text":"64(2019) Artikel-Nummer 153061, 8 Seiten"},"physDesc":[{"extent":"Online-Ressource"}],"title":[{"title":"Phytomedicine","title_sort":"Phytomedicine","subtitle":"international journal of phytotherapy and phytopharmacology"}],"origin":[{"dateIssuedDisp":"1994-","publisher":"Elsevier ; Urban & Fischer","publisherPlace":"München [u.a.] ; Jena","dateIssuedKey":"1994"}]}],"note":["Available online 31 July 2019","Gesehen am 08.01.2020"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"id":{"eki":["1686665172"],"doi":["10.1016/j.phymed.2019.153061"]},"physDesc":[{"extent":"8 S."}],"language":["eng"],"title":[{"title":"Glochidion zeylanicum leaf extracts exhibit lifespan extending and oxidative stress resistance properties in Caenorhabditis elegans via DAF-16/FoxO and SKN-1/Nrf-2 signaling pathways","title_sort":"Glochidion zeylanicum leaf extracts exhibit lifespan extending and oxidative stress resistance properties in Caenorhabditis elegans via DAF-16/FoxO and SKN-1/Nrf-2 signaling pathways"}],"recId":"1686665172","name":{"displayForm":["Chatrawee Duangjan, Panthakarn Rangsinth, Xiaojie Gu, Shaoxiong Zhang, Michael Wink, Tewin Tencomnao"]},"origin":[{"dateIssuedDisp":"31 July 2019","dateIssuedKey":"2019"}],"person":[{"display":"Duangjan, Chatrawee","given":"Chatrawee","family":"Duangjan","role":"aut"},{"role":"aut","family":"Wink","display":"Wink, Michael","given":"Michael"}]} | ||
| SRT | |a DUANGJANCHGLOCHIDION3120 | ||