Neurological soft signs and grey matter abnormalities in individuals with ultra-high risk for psychosis

Neurological soft signs (NSSs), conventionally defined as subtle neurological abnormalities, are frequently found in individuals with schizophrenia. Many neuroimaging studies have also reported that NSSs are associated with grey matter changes in patients with schizophrenia at different stages of th...

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Hauptverfasser: Kong, Li (VerfasserIn) , Herold, Christina (VerfasserIn) , Schröder, Johannes (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 2019
In: PsyCh journal
Year: 2018, Jahrgang: 8, Heft: 2, Pages: 252-260
ISSN:2046-0260
DOI:10.1002/pchj.258
Online-Zugang:Resolving-System, Volltext: https://doi.org/10.1002/pchj.258
Verlag: https://onlinelibrary.wiley.com/doi/abs/10.1002/pchj.258
Volltext
Verfasserangaben:Li Kong, Huiru Cui, Tianhong Zhang, Ya Wang, Jia Huang, Yikang Zhu, Yingying Tang, Christina J. Herold, Johannes Schröder, Eric F.C. Cheung, Raymond C.K. Chan, and Jijun Wang

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520 |a Neurological soft signs (NSSs), conventionally defined as subtle neurological abnormalities, are frequently found in individuals with schizophrenia. Many neuroimaging studies have also reported that NSSs are associated with grey matter changes in patients with schizophrenia at different stages of the illness. However, these findings may be confounded by the effect of antipsychotic medications, chronicity, and duration of untreated psychosis. Examining NSSs in individuals with ultra-high risk (UHR) for psychosis may help to identify the neuroanatomical substrates of NSSs related to the illness itself and to avoid these potential confounding effects. A sample of 21 individuals with UHR were included in the present study. 
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