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PI4KIII inhibitor enviroxime impedes the replication of the hepatitis C virus by inhibiting PI3 kinases

Abstract. Objectives: Many positive-stranded RNA viruses, including HCV, drastically remodel intracellular membranes to generate specialized environments for RNA including HCV, drastically remodel intracellular membranes to generate specialized environments for RNA replication. Phosphatidylinositol...

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Bibliographische Detailangaben
Hauptverfasser: Delang, Leen (VerfasserIn) , Harak, Christian (VerfasserIn) , Benkheil, Mohammed (VerfasserIn) , Khan, Hayat (VerfasserIn) , Leyssen, Pieter (VerfasserIn) , Andrews, Martin (VerfasserIn) , Lohmann, Volker (VerfasserIn) , Neyts, Johan (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 14 September 2018
In: The journal of antimicrobial chemotherapy
Year: 2018, Jahrgang: 73, Heft: 12, Pages: 3375-3384
ISSN:1460-2091
DOI:10.1093/jac/dky327
Online-Zugang:Verlag, kostenfrei, Volltext: https://doi.org/10.1093/jac/dky327
Verlag, kostenfrei, Volltext: https://academic.oup.com/jac/article/73/12/3375/5096849
Volltext
Verfasserangaben:Leen Delang, Christian Harak, Mohammed Benkheil, Hayat Khan, Pieter Leyssen, Martin Andrews, Volker Lohmann, Johan Neyts
Beschreibung
Zusammenfassung:Abstract. Objectives: Many positive-stranded RNA viruses, including HCV, drastically remodel intracellular membranes to generate specialized environments for RNA including HCV, drastically remodel intracellular membranes to generate specialized environments for RNA replication. Phosphatidylinositol 4-kinase III (PI4KIII)α plays an essential role in the formation of HCV replication complexes and has therefore been explored as a potential drug target. Here, we characterized the anti-HCV activity of the PI4KIII inhibitors enviroxime and BF738735 and elucidated their mechanism of action
Beschreibung:Gesehen am 20.01.2020
Beschreibung:Online Resource
ISSN:1460-2091
DOI:10.1093/jac/dky327

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