A hypothesis of radioresistance and cell-survival curve shape based on cell-cycle progression and damage tolerance
Exponential survival curves of early-passage humanfibroblasts challenge classic biophysical models of cell inactivation. Thus,X-ray doses of 2–4 Gy inactivate normal, human skinfibroblasts in spite of negligible residual double-strand breaks. By con-trast, radioresistant p53-mutant U251 glioblastoma...
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| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
2019
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| In: |
Radiation protection dosimetry
Year: 2019, Volume: 183, Issue: 1/2, Pages: 107-110 |
| ISSN: | 1742-3406 |
| DOI: | 10.1093/rpd/ncy247 |
| Online Access: | Verlag, Volltext: https://doi.org/10.1093/rpd/ncy247 Verlag: https://academic.oup.com/rpd/article/183/1-2/107/5238184 
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| Author Notes: | Carsten Herskind, Qi Liu, Xiaolei Liu, Yingying Zhang, Lin Ma, Elsa Angelie, Hui Hui Ma, Junqi Liu, Frank A. Giordano, Frederik Wenz and Marlon R. Veldwijk |
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| 520 | |a Exponential survival curves of early-passage humanfibroblasts challenge classic biophysical models of cell inactivation. Thus,X-ray doses of 2–4 Gy inactivate normal, human skinfibroblasts in spite of negligible residual double-strand breaks. By con-trast, radioresistant p53-mutant U251 glioblastoma cells proliferate in spite of residual damage. Similarly, p53 wildtype TK6lymphoblastoid cells show exponential survival curves while the related p53-mutant WTK1 cell line continued to proliferateand showed a shouldered survival curve. Here, we propose a model in which the radioresistant shoulder region is due to toler-ance to certain types or amounts of residual damage that would otherwise inactivate normal cells. Thus, the steeper initialslope and absence of a shoulder in the survival curve of normal cells may not imply a higher number of residual lesions butrather non-tolerance to these lesions. | ||
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