High hepatic expression of PDK4 improves survival upon multimodal treatment of colorectal liver metastases
Patients with borderline resectable colorectal liver metastases (CRLM) frequently receive neoadjuvant chemotherapy (NC) to reduce tumour burden, thus making surgical resection feasible. Even though NC can induce severe liver injury, most studies investigating tissue-based prognostic markers focus on...
Gespeichert in:
| Hauptverfasser: | , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
27 February 2019
|
| In: |
British journal of cancer
Year: 2019, Jahrgang: 120, Heft: 7, Pages: 675-688 |
| ISSN: | 1532-1827 |
| DOI: | 10.1038/s41416-019-0406-9 |
| Online-Zugang: | Verlag, Volltext: https://doi.org/10.1038/s41416-019-0406-9 Verlag: https://www.nature.com/articles/s41416-019-0406-9 
|
| Verfasserangaben: | Moritz J. Strowitzki, Praveen Radhakrishnan, Sandra Pavicevic, Jana Scheer, Gwendolyn Kimmer, Alina S. Ritter, Christopher Tuffs, Claudia Volz, Florian Vondran, Jonathan M. Harnoss, Johannes Klose, Thomas Schmidt and Martin Schneider |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1688547614 | ||
| 003 | DE-627 | ||
| 005 | 20220817214259.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 200127s2019 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1038/s41416-019-0406-9 |2 doi | |
| 035 | |a (DE-627)1688547614 | ||
| 035 | |a (DE-599)KXP1688547614 | ||
| 035 | |a (OCoLC)1341299567 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Strowitzki, Moritz |d 1987- |e VerfasserIn |0 (DE-588)1071578561 |0 (DE-627)82605532X |0 (DE-576)433164638 |4 aut | |
| 245 | 1 | 0 | |a High hepatic expression of PDK4 improves survival upon multimodal treatment of colorectal liver metastases |c Moritz J. Strowitzki, Praveen Radhakrishnan, Sandra Pavicevic, Jana Scheer, Gwendolyn Kimmer, Alina S. Ritter, Christopher Tuffs, Claudia Volz, Florian Vondran, Jonathan M. Harnoss, Johannes Klose, Thomas Schmidt and Martin Schneider |
| 264 | 1 | |c 27 February 2019 | |
| 300 | |a 14 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 27.01.2020 | ||
| 520 | |a Patients with borderline resectable colorectal liver metastases (CRLM) frequently receive neoadjuvant chemotherapy (NC) to reduce tumour burden, thus making surgical resection feasible. Even though NC can induce severe liver injury, most studies investigating tissue-based prognostic markers focus on tumour tissue. Here, we assessed the prognostic significance of pyruvate-dehydrogenase-kinase isoenzyme 4 (PDK4) within liver tissue of patients undergoing surgical resection due to CRLM. Transcript levels of hypoxia-adaptive genes (such as PDK isoenzymes) were assessed in the tissue of healthy liver, corresponding CRLM, healthy colon mucosa and corresponding tumour. Uni- and multivariate analyses were performed. Responses to chemotherapy upon up- or down-regulation of PDK4 were studied in vitro. PDK4 expression within healthy liver tissue was associated with increased overall survival and liver function following surgical resection of CRLM. This association was enhanced in patients with NC. PDK4 expression in CRLM tissue did not correlate with overall survival. Up-regulation of PDK4 increased the resistance of hepatocytes and colon cancer cells against chemotherapy-induced toxicity, whereas knockdown of PDK4 enhanced chemotherapy-associated cell damage. Our findings suggest that up-regulated PDK4 expression reduces hepatic chemotherapy-induced oxidative stress and is associated with improved postoperative liver function in patients undergoing multimodal treatment and resection of CRLM. | ||
| 700 | 1 | |a Radhakrishnan, Praveen |d 1985- |e VerfasserIn |0 (DE-588)1082783137 |0 (DE-627)84779220X |0 (DE-576)455565694 |4 aut | |
| 700 | 1 | |a Ritter, Alina |d 1993- |e VerfasserIn |0 (DE-588)1120950007 |0 (DE-627)874145775 |0 (DE-576)480623031 |4 aut | |
| 700 | 1 | |a Volz, Claudia |d 1991- |e VerfasserIn |0 (DE-588)1120947421 |0 (DE-627)874145554 |0 (DE-576)480620229 |4 aut | |
| 700 | 1 | |a Harnoß, Jonathan M. |d 1986- |e VerfasserIn |0 (DE-588)1065010915 |0 (DE-627)827807511 |0 (DE-576)424699524 |4 aut | |
| 700 | 1 | |a Klose, Johannes |d 1981- |e VerfasserIn |0 (DE-588)138129274 |0 (DE-627)599747706 |0 (DE-576)306578387 |4 aut | |
| 700 | 1 | |a Schmidt, Thomas |d 1980- |e VerfasserIn |0 (DE-588)132383152 |0 (DE-627)521950023 |0 (DE-576)260799149 |4 aut | |
| 700 | 1 | |a Schneider, Martin |d 1976- |e VerfasserIn |0 (DE-588)12390384X |0 (DE-627)706468147 |0 (DE-576)42325037X |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t British journal of cancer |d Edinburgh : Nature Publ. Group, 1947 |g 120(2019), 7, Seite 675-688 |h Online-Ressource |w (DE-627)320420094 |w (DE-600)2002452-6 |w (DE-576)103746854 |x 1532-1827 |7 nnas |a High hepatic expression of PDK4 improves survival upon multimodal treatment of colorectal liver metastases |
| 773 | 1 | 8 | |g volume:120 |g year:2019 |g number:7 |g pages:675-688 |g extent:14 |a High hepatic expression of PDK4 improves survival upon multimodal treatment of colorectal liver metastases |
| 856 | 4 | 0 | |u https://doi.org/10.1038/s41416-019-0406-9 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u https://www.nature.com/articles/s41416-019-0406-9 |x Verlag |
| 951 | |a AR | ||
| 992 | |a 20200127 | ||
| 993 | |a Article | ||
| 994 | |a 2019 | ||
| 998 | |g 12390384X |a Schneider, Martin |m 12390384X:Schneider, Martin |d 910000 |d 910200 |e 910000PS12390384X |e 910200PS12390384X |k 0/910000/ |k 1/910000/910200/ |p 13 |y j | ||
| 998 | |g 132383152 |a Schmidt, Thomas |m 132383152:Schmidt, Thomas |d 910000 |d 910200 |d 50000 |e 910000PS132383152 |e 910200PS132383152 |e 50000PS132383152 |k 0/910000/ |k 1/910000/910200/ |k 0/50000/ |p 12 | ||
| 998 | |g 138129274 |a Klose, Johannes |m 138129274:Klose, Johannes |d 910000 |d 910200 |e 910000PK138129274 |e 910200PK138129274 |k 0/910000/ |k 1/910000/910200/ |p 11 | ||
| 998 | |g 1065010915 |a Harnoß, Jonathan M. |m 1065010915:Harnoß, Jonathan M. |d 50000 |e 50000PH1065010915 |k 0/50000/ |p 10 | ||
| 998 | |g 1120947421 |a Volz, Claudia |m 1120947421:Volz, Claudia |d 910000 |d 910200 |e 910000PV1120947421 |e 910200PV1120947421 |k 0/910000/ |k 1/910000/910200/ |p 8 | ||
| 998 | |g 1120950007 |a Ritter, Alina |m 1120950007:Ritter, Alina |d 910000 |d 910300 |e 910000PR1120950007 |e 910300PR1120950007 |k 0/910000/ |k 1/910000/910300/ |p 6 | ||
| 998 | |g 1082783137 |a Radhakrishnan, Praveen |m 1082783137:Radhakrishnan, Praveen |d 910000 |d 910200 |e 910000PR1082783137 |e 910200PR1082783137 |k 0/910000/ |k 1/910000/910200/ |p 2 | ||
| 998 | |g 1071578561 |a Strowitzki, Moritz |m 1071578561:Strowitzki, Moritz |d 910000 |d 910200 |e 910000PS1071578561 |e 910200PS1071578561 |k 0/910000/ |k 1/910000/910200/ |p 1 |x j | ||
| 999 | |a KXP-PPN1688547614 |e 3582555011 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"recId":"1688547614","note":["Gesehen am 27.01.2020"],"name":{"displayForm":["Moritz J. Strowitzki, Praveen Radhakrishnan, Sandra Pavicevic, Jana Scheer, Gwendolyn Kimmer, Alina S. Ritter, Christopher Tuffs, Claudia Volz, Florian Vondran, Jonathan M. Harnoss, Johannes Klose, Thomas Schmidt and Martin Schneider"]},"relHost":[{"id":{"zdb":["2002452-6"],"issn":["1532-1827"],"eki":["320420094"]},"type":{"media":"Online-Ressource","bibl":"periodical"},"language":["eng"],"origin":[{"publisherPlace":"Edinburgh ; Edinburgh","dateIssuedDisp":"1947-","publisher":"Nature Publ. Group ; Churchill Livingstone","dateIssuedKey":"1947"}],"part":{"issue":"7","year":"2019","extent":"14","pages":"675-688","text":"120(2019), 7, Seite 675-688","volume":"120"},"titleAlt":[{"title":"BJC"}],"title":[{"title_sort":"British journal of cancer","subtitle":"BJC","title":"British journal of cancer"}],"physDesc":[{"extent":"Online-Ressource"}],"disp":"High hepatic expression of PDK4 improves survival upon multimodal treatment of colorectal liver metastasesBritish journal of cancer","pubHistory":["Volume 1, issue 1 (1 March 1947)-"],"note":["Gesehen am 27.10.25"],"recId":"320420094"}],"physDesc":[{"extent":"14 S."}],"person":[{"family":"Strowitzki","display":"Strowitzki, Moritz","given":"Moritz","role":"aut"},{"given":"Praveen","display":"Radhakrishnan, Praveen","family":"Radhakrishnan","role":"aut"},{"given":"Alina","display":"Ritter, Alina","family":"Ritter","role":"aut"},{"given":"Claudia","display":"Volz, Claudia","family":"Volz","role":"aut"},{"given":"Jonathan M.","family":"Harnoß","display":"Harnoß, Jonathan M.","role":"aut"},{"role":"aut","given":"Johannes","family":"Klose","display":"Klose, Johannes"},{"role":"aut","family":"Schmidt","display":"Schmidt, Thomas","given":"Thomas"},{"family":"Schneider","display":"Schneider, Martin","given":"Martin","role":"aut"}],"title":[{"title":"High hepatic expression of PDK4 improves survival upon multimodal treatment of colorectal liver metastases","title_sort":"High hepatic expression of PDK4 improves survival upon multimodal treatment of colorectal liver metastases"}],"id":{"eki":["1688547614"],"doi":["10.1038/s41416-019-0406-9"]},"language":["eng"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"origin":[{"dateIssuedKey":"2019","dateIssuedDisp":"27 February 2019"}]} | ||
| SRT | |a STROWITZKIHIGHHEPATI2720 | ||