Buchumschlag

FOXI1 immunohistochemistry differentiates benign renal oncocytoma from malignant chromophobe renal cell carcinoma

Weitere Versionen anzeigen (2)

Background/Aim: Renal oncocytoma (RO) and chromophobe renal cell carcinoma (chRCC) are suggested to develop from α- and β-intercalated (IC) cells of the collecting duct expressing solute carrier family 4 member 1 (SLC4A1) and SLC26A4 under control of forkhead box 1 (FOXI1) transcription factor. The...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Molnár, Ágnes (VerfasserIn) , Kovacs, Gyula (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 2019
In: Anticancer research
Year: 2019, Jahrgang: 39, Heft: 6, Pages: 2785-2790
ISSN:1791-7530
DOI:10.21873/anticanres.13405
Online-Zugang:Verlag, Volltext: https://doi.org/10.21873/anticanres.13405
Verlag, Volltext: http://ar.iiarjournals.org/content/39/6/2785
Volltext
Verfasserangaben:Agnes Molnar, Csenge Anna Horvath, Petra Czovek, Arpad Szanto and Gyula Kovacs

MARC

LEADER 00000caa a22000002c 4500
001 1688636110
003 DE-627
005 20220817214755.0
007 cr uuu---uuuuu
008 200128s2019 xx |||||o 00| ||eng c
024 7 |a 10.21873/anticanres.13405  |2 doi 
035 |a (DE-627)1688636110 
035 |a (DE-599)KXP1688636110 
035 |a (OCoLC)1341299622 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Molnár, Ágnes  |e VerfasserIn  |0 (DE-588)1203818068  |0 (DE-627)1688928863  |4 aut 
245 1 0 |a FOXI1 immunohistochemistry differentiates benign renal oncocytoma from malignant chromophobe renal cell carcinoma  |c Agnes Molnar, Csenge Anna Horvath, Petra Czovek, Arpad Szanto and Gyula Kovacs 
246 3 0 |a one 
264 1 |c 2019 
300 |a 6 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a accepted May 23, 2019 
500 |a Gesehen am 30.01.2020 
520 |a Background/Aim: Renal oncocytoma (RO) and chromophobe renal cell carcinoma (chRCC) are suggested to develop from α- and β-intercalated (IC) cells of the collecting duct expressing solute carrier family 4 member 1 (SLC4A1) and SLC26A4 under control of forkhead box 1 (FOXI1) transcription factor. The aim of this study was to clarify the possible cellular origin and of RO and chRCC. Materials and Methods: Immunohistochemistry for aquaporin 2 (AQP2), FOXI1, SLC4A1 and SLC16A4 was applied to distinct types of renal cell tumors. Results: Nuclear FOXI1 staining occurred in 96% of 83 ROs, in 3% of 90 chRCCs and none of the other tumor types. The α-IC cell marker SLC4A1 was seen in 60% of RO and 11% of chRCC, whereas staining for the β-IC cell marker SLC26A4 was negative in all but one tumor. Conclusion: Although the origin of RO remains unclear, our findings suggest that FOXI1 immunohistochemistry is useful in differential diagnosis of RO from chRCC with overlapping histology. 
650 4 |a chromophobe renal cell carcinoma 
650 4 |a differential diagnosis 
650 4 |a FOXI1 
650 4 |a immunohistochemistry 
650 4 |a Renal oncocytoma 
700 1 |a Kovacs, Gyula  |e VerfasserIn  |0 (DE-588)1081747579  |0 (DE-627)846587424  |0 (DE-576)454756399  |4 aut 
773 0 8 |i Enthalten in  |t Anticancer research  |d Kapandriti, Attiki, Greece : International Institute of Anticancer Research, 2004  |g 39(2019), 6, Seite 2785-2790  |h Online-Ressource  |w (DE-627)387478493  |w (DE-600)2145376-7  |w (DE-576)358408717  |x 1791-7530  |7 nnas  |a FOXI1 immunohistochemistry differentiates benign renal oncocytoma from malignant chromophobe renal cell carcinoma 
773 1 8 |g volume:39  |g year:2019  |g number:6  |g pages:2785-2790  |g extent:6  |a FOXI1 immunohistochemistry differentiates benign renal oncocytoma from malignant chromophobe renal cell carcinoma 
856 4 0 |u https://doi.org/10.21873/anticanres.13405  |x Verlag  |x Resolving-System  |3 Volltext 
856 4 0 |u http://ar.iiarjournals.org/content/39/6/2785  |x Verlag  |3 Volltext 
951 |a AR 
992 |a 20200128 
993 |a Article 
994 |a 2019 
998 |g 1081747579  |a Kovacs, Gyula  |m 1081747579:Kovacs, Gyula  |d 50000  |e 50000PK1081747579  |k 0/50000/  |p 5  |y j 
999 |a KXP-PPN1688636110  |e 358282876X 
BIB |a Y 
SER |a journal 
JSO |a {"origin":[{"dateIssuedDisp":"2019","dateIssuedKey":"2019"}],"id":{"eki":["1688636110"],"doi":["10.21873/anticanres.13405"]},"name":{"displayForm":["Agnes Molnar, Csenge Anna Horvath, Petra Czovek, Arpad Szanto and Gyula Kovacs"]},"physDesc":[{"extent":"6 S."}],"relHost":[{"name":{"displayForm":["International Institute of Anticancer Research"]},"origin":[{"publisherPlace":"Kapandriti, Attiki, Greece","dateIssuedKey":"2004","publisher":"International Institute of Anticancer Research","dateIssuedDisp":"2004-"}],"id":{"zdb":["2145376-7"],"eki":["387478493"],"issn":["1791-7530"]},"physDesc":[{"extent":"Online-Ressource"}],"title":[{"title_sort":"Anticancer research","title":"Anticancer research","subtitle":"international journal of cancer research and treatment"}],"disp":"FOXI1 immunohistochemistry differentiates benign renal oncocytoma from malignant chromophobe renal cell carcinomaAnticancer research","note":["Gesehen am 26.02.13"],"type":{"bibl":"periodical","media":"Online-Ressource"},"language":["eng"],"recId":"387478493","pubHistory":["Nachgewiesen 24.2004 -"],"part":{"pages":"2785-2790","issue":"6","year":"2019","extent":"6","volume":"39","text":"39(2019), 6, Seite 2785-2790"}}],"title":[{"title_sort":"FOXI1 immunohistochemistry differentiates benign renal oncocytoma from malignant chromophobe renal cell carcinoma","title":"FOXI1 immunohistochemistry differentiates benign renal oncocytoma from malignant chromophobe renal cell carcinoma"}],"person":[{"family":"Molnár","given":"Ágnes","roleDisplay":"VerfasserIn","display":"Molnár, Ágnes","role":"aut"},{"roleDisplay":"VerfasserIn","display":"Kovacs, Gyula","role":"aut","family":"Kovacs","given":"Gyula"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"note":["accepted May 23, 2019","Gesehen am 30.01.2020"],"language":["eng"],"recId":"1688636110"} 
SRT |a MOLNARAGNEFOXI1IMMUN2019 

Ähnliche Einträge