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Human SAMHD1 restricts the xenotransplantation relevant porcine endogenous retrovirus (PERV) in non-dividing cells

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The release of porcine endogenous retrovirus (PERV) particles from pig cells is a potential risk factor during xenotransplantation by way of productively infecting the human transplant recipient. Potential countermeasures against PERV replication are restriction factors that block retroviral replica...

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Main Authors: Al-shehabi, Hussein (Author) , Kutzner, Juliane (Author) , Schaller, Torsten (Author)
Format: Article (Journal)
Language:English
Published: 15 February 2019
In: Journal of general virology
Year: 2019, Volume: 100, Issue: 4, Pages: 656-661
ISSN:1465-2099
DOI:10.1099/jgv.0.001232
Online Access:Verlag, Volltext: https://doi.org/10.1099/jgv.0.001232
Verlag: https://www.microbiologyresearch.org/content/journal/jgv/10.1099/jgv.0.001232
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Author Notes:Hussein Al-Shehabi, Uwe Fiebig, Juliane Kutzner, Joachim Denner, Torsten Schaller, Norbert Bannert, Henning Hofmann
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The ability of SAMHD1 to block HIV-1 but not SIV requires expression of MxB by Buffone, Cindy (Author) , Kutzner, Juliane (Author) , Schaller, Torsten (Author) ,


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