Endocannabinoid signalling in atherosclerosis and related metabolic complications
Endocannabinoids are a group of arachidonic acid-derived lipid mediators binding to cannabinoid receptors CB1 and CB2. An overactivity of the endocannabinoid system plays a pathophysiological role in the development of visceral obesity and insulin resistance. Moreover, elevated circulating endocanna...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
15. Februar 2019
|
| In: |
Thrombosis and haemostasis
Year: 2019, Volume: 119, Issue: 4, Pages: 567-575 |
| ISSN: | 2567-689X |
| DOI: | 10.1055/s-0039-1678738 |
| Online Access: | Verlag, Volltext: https://doi.org/10.1055/s-0039-1678738 Verlag: http://www.thieme-connect.de/DOI/DOI?10.1055/s-0039-1678738 
|
| Author Notes: | Raquel Guillamat-Prats, Martina Rami, Stephan Herzig, Sabine Steffens |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1688791574 | ||
| 003 | DE-627 | ||
| 005 | 20231026105322.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 200129s2019 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1055/s-0039-1678738 |2 doi | |
| 035 | |a (DE-627)1688791574 | ||
| 035 | |a (DE-599)KXP1688791574 | ||
| 035 | |a (OCoLC)1341299925 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Guillamat-Prats, Raquel |e VerfasserIn |0 (DE-588)1203744943 |0 (DE-627)1688792228 |4 aut | |
| 245 | 1 | 0 | |a Endocannabinoid signalling in atherosclerosis and related metabolic complications |c Raquel Guillamat-Prats, Martina Rami, Stephan Herzig, Sabine Steffens |
| 264 | 1 | |c 15. Februar 2019 | |
| 300 | |a 9 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 29.01.2020 | ||
| 520 | |a Endocannabinoids are a group of arachidonic acid-derived lipid mediators binding to cannabinoid receptors CB1 and CB2. An overactivity of the endocannabinoid system plays a pathophysiological role in the development of visceral obesity and insulin resistance. Moreover, elevated circulating endocannabinoid levels are also prevalent in atherosclerosis. The pathophysiological increase of endocannabinoid levels is due to an altered expression of endocannabinoid synthesizing and degrading enzymes induced by inflammatory mediators such as cytokines or lipids. Emerging experimental evidence suggests that enhanced endocannabinoid signalling affects atherosclerosis via multiple effects, including a modulation of vascular inflammation, leukocyte recruitment, macrophage cholesterol metabolism and consequently atherosclerotic plaque stability. In addition, recent findings in various metabolic disease models highlight the relevance of peripheral CB1 cannabinoid receptors in adipose tissue, liver and pancreas, which crucially regulate lipid and glucose metabolism as well as macrophage properties in these organs. This suggests that targeting the endocannabinoid system in the vasculature and peripheral organs might have a therapeutic potential for atherosclerosis by inhibiting vascular inflammation and improving metabolic risk factors. This review will provide a brief update on the effects of endocannabinoid signalling in atherosclerosis and related metabolic complications. | ||
| 700 | 1 | |a Herzig, Stephan |d 1969- |e VerfasserIn |0 (DE-588)12146623X |0 (DE-627)705470857 |0 (DE-576)292725949 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Thrombosis and haemostasis |d Stuttgart : Thieme, 1976 |g 119(2019), 4, Seite 567-575 |h Online-Ressource |w (DE-627)302723188 |w (DE-600)1492370-1 |w (DE-576)079877362 |x 2567-689X |7 nnas |a Endocannabinoid signalling in atherosclerosis and related metabolic complications |
| 773 | 1 | 8 | |g volume:119 |g year:2019 |g number:4 |g pages:567-575 |g extent:9 |a Endocannabinoid signalling in atherosclerosis and related metabolic complications |
| 856 | 4 | 0 | |u https://doi.org/10.1055/s-0039-1678738 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u http://www.thieme-connect.de/DOI/DOI?10.1055/s-0039-1678738 |x Verlag |
| 951 | |a AR | ||
| 992 | |a 20200129 | ||
| 993 | |a Article | ||
| 994 | |a 2019 | ||
| 998 | |g 12146623X |a Herzig, Stephan |m 12146623X:Herzig, Stephan |d 50000 |e 50000PH12146623X |k 0/50000/ |p 3 | ||
| 999 | |a KXP-PPN1688791574 |e 3583113977 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"name":{"displayForm":["Raquel Guillamat-Prats, Martina Rami, Stephan Herzig, Sabine Steffens"]},"type":{"bibl":"article-journal","media":"Online-Ressource"},"note":["Gesehen am 29.01.2020"],"origin":[{"dateIssuedDisp":"15. Februar 2019","dateIssuedKey":"2019"}],"physDesc":[{"extent":"9 S."}],"relHost":[{"disp":"Endocannabinoid signalling in atherosclerosis and related metabolic complicationsThrombosis and haemostasis","language":["eng"],"id":{"eki":["302723188"],"issn":["2567-689X"],"zdb":["1492370-1"],"doi":["10.1055/s-00035024"]},"type":{"media":"Online-Ressource","bibl":"periodical"},"pubHistory":["35.1976 -"],"note":["Gesehen am 15.06.2018"],"origin":[{"dateIssuedDisp":"1976-","dateIssuedKey":"1976","publisherPlace":"Stuttgart ; Stuttgart","publisher":"Thieme ; Schattauer"}],"physDesc":[{"extent":"Online-Ressource"}],"part":{"pages":"567-575","issue":"4","extent":"9","text":"119(2019), 4, Seite 567-575","year":"2019","volume":"119"},"title":[{"title_sort":"Thrombosis and haemostasis","title":"Thrombosis and haemostasis","subtitle":"journal of the International Society on Thrombosis and Haemostasis"}],"recId":"302723188"}],"title":[{"title_sort":"Endocannabinoid signalling in atherosclerosis and related metabolic complications","title":"Endocannabinoid signalling in atherosclerosis and related metabolic complications"}],"language":["eng"],"id":{"eki":["1688791574"],"doi":["10.1055/s-0039-1678738"]},"person":[{"family":"Guillamat-Prats","role":"aut","roleDisplay":"VerfasserIn","given":"Raquel","display":"Guillamat-Prats, Raquel"},{"role":"aut","family":"Herzig","display":"Herzig, Stephan","roleDisplay":"VerfasserIn","given":"Stephan"}],"recId":"1688791574"} | ||
| SRT | |a GUILLAMATPENDOCANNAB1520 | ||