Recent developments in the research on biomarkers of cholangiocarcinoma in primary sclerosing cholangitis

Primary sclerosing cholangitis (PSC) is characterized by a chronic inflammatory process of the bile ducts of unclear aetiology. It is often complicated by cholangiocarcinoma (CCA) with a dismal prognosis. Early detection of CCA is important because treatment options for advanced disease are limited....

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Hauptverfasser: Wannhoff, Andreas (VerfasserIn) , Gotthardt, Daniel (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 2019
In: Clinics and research in hepatology and gastroenterology
Year: 2018, Jahrgang: 43, Heft: 3, Pages: 236-243
ISSN:2210-741X
DOI:10.1016/j.clinre.2018.08.013
Online-Zugang:Verlag, Volltext: https://doi.org/10.1016/j.clinre.2018.08.013
Verlag: http://www.sciencedirect.com/science/article/pii/S2210740118301773
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Verfasserangaben:Wannhoff, Andreas, Gotthardt, Daniel N.

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520 |a Primary sclerosing cholangitis (PSC) is characterized by a chronic inflammatory process of the bile ducts of unclear aetiology. It is often complicated by cholangiocarcinoma (CCA) with a dismal prognosis. Early detection of CCA is important because treatment options for advanced disease are limited. Besides the established markers, like CA19-9, recent developments have been made using latest technologies. This review summarizes the recent advances and remaining limitations of biomarkers of CCA in PSC. 
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