Targeting the PI3K/Akt/mTOR pathway with the pan-Akt inhibitor GDC-0068 in PIK3CA-mutant breast cancer brain metastases
AbstractBackground. Activating mutations in the pathway of phosphatidylinositol-3 kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) occur in 43-70% of bre
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| Hauptverfasser: | , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
07 June 2019
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| In: |
Neuro-Oncology
Year: 2019, Jahrgang: 21, Heft: 11, Pages: 1401-1411 |
| ISSN: | 1523-5866 |
| DOI: | 10.1093/neuonc/noz105 |
| Online-Zugang: | Verlag, Volltext: https://doi.org/10.1093/neuonc/noz105 Verlag, Volltext: https://academic.oup.com/neuro-oncology/article/21/11/1401/5512506 
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| Verfasserangaben: | Franziska Maria Ippen, Julia Katharina Grosch, Megha Subramanian, Benjamin Macfarlane Kuter, Bianca M. Liederer, Emile G. Plise, Joana Liliana Mora, Naema Nayyar, Stephen Paul Schmidt, Anita Giobbie-Hurder, Maria Martinez-Lage, Scott L. Carter, Daniel P. Cahill, Hiroaki Wakimoto, and Priscilla Kaliopi Brastianos |
| Zusammenfassung: | AbstractBackground. Activating mutations in the pathway of phosphatidylinositol-3 kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) occur in 43-70% of bre |
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| Beschreibung: | Gesehen am 30.01.2020 |
| Beschreibung: | Online Resource |
| ISSN: | 1523-5866 |
| DOI: | 10.1093/neuonc/noz105 |