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Processive extrusion of polypeptide loops by a Hsp100 disaggregase

A combination of optical tweezers and fluorescent-particle tracking is used to dissect the dynamics of the Hsp100 disaggregase ClpB, and show that the processive extrusion of polypeptide loops is the mechanistic basis of its activity.

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Bibliographic Details
Main Authors: Avellaneda, Mario (Author) , Franke, Kamila B. (Author) , Bukau, Bernd (Author) , Mogk, Axel (Author)
Format: Article (Journal)
Language:English
Published: 29 January 2020
In: Nature
Year: 2020, Volume: 578, Issue: 7794, Pages: 317-320
ISSN:1476-4687
DOI:10.1038/s41586-020-1964-y
Online Access:Resolving-System, Volltext: https://doi.org/10.1038/s41586-020-1964-y
Verlag: https://www.nature.com/articles/s41586-020-1964-y
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Author Notes:Mario J. Avellaneda, Kamila B. Franke, Vanda Sunderlikova, Bernd Bukau, Axel Mogk & Sander J. Tans
Description
Summary:A combination of optical tweezers and fluorescent-particle tracking is used to dissect the dynamics of the Hsp100 disaggregase ClpB, and show that the processive extrusion of polypeptide loops is the mechanistic basis of its activity.
Item Description:Das PDF enthält zusätzlich einen Anhang von 15 Seiten
Gesehen am 31.01.2020
Physical Description:Online Resource
ISSN:1476-4687
DOI:10.1038/s41586-020-1964-y

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