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Processive extrusion of polypeptide loops by a Hsp100 disaggregase

A combination of optical tweezers and fluorescent-particle tracking is used to dissect the dynamics of the Hsp100 disaggregase ClpB, and show that the processive extrusion of polypeptide loops is the mechanistic basis of its activity.

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Bibliographische Detailangaben
Hauptverfasser: Avellaneda, Mario (VerfasserIn) , Franke, Kamila B. (VerfasserIn) , Bukau, Bernd (VerfasserIn) , Mogk, Axel (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 29 January 2020
In: Nature
Year: 2020, Jahrgang: 578, Heft: 7794, Pages: 317-320
ISSN:1476-4687
DOI:10.1038/s41586-020-1964-y
Online-Zugang:Resolving-System, Volltext: https://doi.org/10.1038/s41586-020-1964-y
Verlag: https://www.nature.com/articles/s41586-020-1964-y
Volltext
Verfasserangaben:Mario J. Avellaneda, Kamila B. Franke, Vanda Sunderlikova, Bernd Bukau, Axel Mogk & Sander J. Tans

MARC

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