Magnetic resonance imaging surrogates of molecular subgroups in atypical teratoid/rhabdoid tumor
Abstract: Background. Recently, 3 molecular subgroups of atypical teratoid/rhabdoid tumor (ATRT) were identified, but little is known of their clinical and magnetic resonance imaging (MRI) characteristics. Methods. A total of 43 patients with known molecular subgroup status (ATRT–sonic hedgehog [SH...
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
13 July 2018
|
| In: |
Neuro-Oncology
Year: 2018, Jahrgang: 20, Heft: 12, Pages: 1672-1679 |
| ISSN: | 1523-5866 |
| DOI: | 10.1093/neuonc/noy111 |
| Online-Zugang: | Verlag, Volltext: https://doi.org/10.1093/neuonc/noy111 Verlag, Volltext: https://academic.oup.com/neuro-oncology/article/20/12/1672/5053230 
|
| Verfasserangaben: | Johannes Nowak, Karolina Nemes, Annika Hohm, Lindsey A. Vandergrift, Martin Hasselblatt, Pascal D. Johann, Marcel Kool, Michael C. Frühwald, and Monika Warmuth-Metz |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 168958338X | ||
| 003 | DE-627 | ||
| 005 | 20220817224446.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 200206s2018 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1093/neuonc/noy111 |2 doi | |
| 035 | |a (DE-627)168958338X | ||
| 035 | |a (DE-599)KXP168958338X | ||
| 035 | |a (OCoLC)1341304157 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Nowak, Johannes |d 19XX- |e VerfasserIn |0 (DE-588)1204245592 |0 (DE-627)1689583681 |4 aut | |
| 245 | 1 | 0 | |a Magnetic resonance imaging surrogates of molecular subgroups in atypical teratoid/rhabdoid tumor |c Johannes Nowak, Karolina Nemes, Annika Hohm, Lindsey A. Vandergrift, Martin Hasselblatt, Pascal D. Johann, Marcel Kool, Michael C. Frühwald, and Monika Warmuth-Metz |
| 264 | 1 | |c 13 July 2018 | |
| 300 | |b Illustrationen | ||
| 300 | |a 8 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Advance access date 13 July 2018 | ||
| 500 | |a Gesehen am 06.02.2020 | ||
| 520 | |a Abstract: Background. Recently, 3 molecular subgroups of atypical teratoid/rhabdoid tumor (ATRT) were identified, but little is known of their clinical and magnetic resonance imaging (MRI) characteristics. Methods. A total of 43 patients with known molecular subgroup status (ATRT–sonic hedgehog [SHH], n = 17; ATRT-tyrosine [TYR], n = 16; ATRT–myelocytomatosis oncogene [MYC], n = 10) were retrieved from the EU-RHAB Registry and analyzed for clinical and MRI features. Results. On MRI review, differences in preferential tumor location were confirmed, with ATRT-TYR being predominantly located infratentorially (P < 0.05). Peritumoral edema was more pronounced in ATRT-MYC compared with ATRT-SHH (P < 0.05) and ATRT-TYR (P < 0.05). Conversely, peripheral tumor cysts were found more frequently in ATRT-SHH (71%) and ATRT-TYR (94%) compared with ATRT-MYC (40%, P < 0.05). Contrast enhancement was absent in 29% of ATRT-SHH (0% of ATRT-TYR; 10% of ATRT-MYC; P < 0.05), and there was a trend toward strong contrast enhancement in ATRT-TYR and ATRT-MYC. We found the characteristic (bandlike) enhancement in 28% of ATRT as well as restricted diffusion in the majority of tumors. A midline/off-midline location in the posterior fossa was also not subgroup specific. Visible meningeal spread (M2) at diagnosis was rare throughout all subgroups. Conclusion. These exploratory findings suggest that MRI features vary across the 3 molecular subgroups of ATRT. Within future prospective trials, MRI may aid diagnosis and treatment stratification | ||
| 700 | 1 | |a Johann, Pascal-David |d 1985- |e VerfasserIn |0 (DE-588)1017717044 |0 (DE-627)690412339 |0 (DE-576)354193791 |4 aut | |
| 700 | 1 | |a Kool, Marcel |e VerfasserIn |0 (DE-588)1058669753 |0 (DE-627)797393560 |0 (DE-576)414823842 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Neuro-Oncology |d Oxford : Oxford Univ. Press, 1999 |g 20(2018), 12, Seite 1672-1679 |h Online-Ressource |w (DE-627)357167341 |w (DE-600)2094060-9 |w (DE-576)318041839 |x 1523-5866 |7 nnas |a Magnetic resonance imaging surrogates of molecular subgroups in atypical teratoid/rhabdoid tumor |
| 773 | 1 | 8 | |g volume:20 |g year:2018 |g number:12 |g pages:1672-1679 |g extent:8 |a Magnetic resonance imaging surrogates of molecular subgroups in atypical teratoid/rhabdoid tumor |
| 856 | 4 | 0 | |u https://doi.org/10.1093/neuonc/noy111 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u https://academic.oup.com/neuro-oncology/article/20/12/1672/5053230 |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20200206 | ||
| 993 | |a Article | ||
| 994 | |a 2018 | ||
| 998 | |g 1058669753 |a Kool, Marcel |m 1058669753:Kool, Marcel |d 50000 |e 50000PK1058669753 |k 0/50000/ |p 7 | ||
| 998 | |g 1017717044 |a Johann, Pascal-David |m 1017717044:Johann, Pascal-David |d 910000 |d 910500 |e 910000PJ1017717044 |e 910500PJ1017717044 |k 0/910000/ |k 1/910000/910500/ |p 6 | ||
| 999 | |a KXP-PPN168958338X |e 3588752714 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"person":[{"family":"Nowak","given":"Johannes","display":"Nowak, Johannes","roleDisplay":"VerfasserIn","role":"aut"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Johann, Pascal-David","family":"Johann","given":"Pascal-David"},{"family":"Kool","given":"Marcel","display":"Kool, Marcel","roleDisplay":"VerfasserIn","role":"aut"}],"note":["Advance access date 13 July 2018","Gesehen am 06.02.2020"],"recId":"168958338X","language":["eng"],"physDesc":[{"noteIll":"Illustrationen","extent":"8 S."}],"relHost":[{"title":[{"subtitle":"official journal of the World Federation of Neuro-Oncology","title_sort":"Neuro-Oncology","title":"Neuro-Oncology"}],"pubHistory":["1.1999 -"],"type":{"bibl":"periodical","media":"Online-Ressource"},"disp":"Magnetic resonance imaging surrogates of molecular subgroups in atypical teratoid/rhabdoid tumorNeuro-Oncology","note":["Gesehen am 21.07.23"],"physDesc":[{"extent":"Online-Ressource"}],"language":["eng"],"recId":"357167341","id":{"eki":["357167341"],"issn":["1523-5866"],"zdb":["2094060-9"]},"origin":[{"dateIssuedDisp":"1999-","dateIssuedKey":"1999","publisherPlace":"Oxford ; Durham, NC","publisher":"Oxford Univ. Press ; Duke University Medical Center"}],"part":{"year":"2018","extent":"8","text":"20(2018), 12, Seite 1672-1679","issue":"12","volume":"20","pages":"1672-1679"}}],"origin":[{"dateIssuedDisp":"13 July 2018","dateIssuedKey":"2018"}],"id":{"eki":["168958338X"],"doi":["10.1093/neuonc/noy111"]},"name":{"displayForm":["Johannes Nowak, Karolina Nemes, Annika Hohm, Lindsey A. Vandergrift, Martin Hasselblatt, Pascal D. Johann, Marcel Kool, Michael C. Frühwald, and Monika Warmuth-Metz"]},"title":[{"title":"Magnetic resonance imaging surrogates of molecular subgroups in atypical teratoid/rhabdoid tumor","title_sort":"Magnetic resonance imaging surrogates of molecular subgroups in atypical teratoid/rhabdoid tumor"}],"type":{"bibl":"article-journal","media":"Online-Ressource"}} | ||
| SRT | |a NOWAKJOHANMAGNETICRE1320 | ||