Cover Image

Surgical management of bisphosphonate-related osteonecrosis of the jaw stages II and III

Objective - The value of surgery in advanced stages of bisphosphonate-related osteonecrosis of the jaw (BRONJ) is still controversial. Hence, we evaluated the effect of surgical therapy in BRONJ stages II and III in combination with a standardized perioperative adjuvant treatment. - Study Design - W...

Full description

Saved in:
Bibliographic Details
Main Authors: Bodem, Jens (Author) , Schaal, Carolin (Author) , Kargus, Steffen (Author) , Saure, Daniel (Author) , Mertens, Christian (Author) , Engel, Michael (Author) , Hoffmann, Jürgen (Author) , Freudlsperger, Christian (Author)
Format: Article (Journal)
Language:English
Published: 2016
In: Oral surgery, oral medicine, oral pathology, oral radiology, and endodontology
Year: 2016, Volume: 121, Issue: 4, Pages: 367-372
ISSN:1528-395X
DOI:10.1016/j.oooo.2015.10.033
Online Access:Verlag, Volltext: https://doi.org/10.1016/j.oooo.2015.10.033
Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S2212440315012961
Get full text
Author Notes:Jens Philipp Bodem, MD, DDS, Carolin Schaal, DDS, Steffen Kargus, MD, DDS, Daniel Saure, PhD, Christian Mertens, DDS, Michael Engel, MD, DDS, Jürgen Hoffmann, MD, DDS, and Christian Freudlsperger, MD, DDS

MARC

LEADER 00000caa a2200000 c 4500
001 1689784822
003 DE-627
005 20240404193231.0
007 cr uuu---uuuuu
008 200211s2016 xx |||||o 00| ||eng c
024 7 |a 10.1016/j.oooo.2015.10.033  |2 doi 
035 |a (DE-627)1689784822 
035 |a (DE-599)KXP1689784822 
035 |a (OCoLC)1341305005 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Bodem, Jens  |d 1979-  |e VerfasserIn  |0 (DE-588)130671002  |0 (DE-627)50557666X  |0 (DE-576)298335107  |4 aut 
245 1 0 |a Surgical management of bisphosphonate-related osteonecrosis of the jaw stages II and III  |c Jens Philipp Bodem, MD, DDS, Carolin Schaal, DDS, Steffen Kargus, MD, DDS, Daniel Saure, PhD, Christian Mertens, DDS, Michael Engel, MD, DDS, Jürgen Hoffmann, MD, DDS, and Christian Freudlsperger, MD, DDS 
264 1 |c 2016 
300 |a 6 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Available online 1 December 2015 
500 |a Gesehen am 11.02.2020 
520 |a Objective - The value of surgery in advanced stages of bisphosphonate-related osteonecrosis of the jaw (BRONJ) is still controversial. Hence, we evaluated the effect of surgical therapy in BRONJ stages II and III in combination with a standardized perioperative adjuvant treatment. - Study Design - We included 39 patients who presented with BRONJ in a total of 47 locations and stages II (n = 23) and III (n = 24). All patients had exclusively received a monthly intravenous application of zoledronic acid. Surgical therapy consisted of complete removal of the necrotic jaw, accompanied by a standardized perioperative adjuvant treatment including intravenous antibiotic prophylaxis, gastric feeding, and an antimicrobiologic mouth rinsing. - Results - Overall, 35 (74.5%) of the 47 BRONJ sites were treated successfully, with success defined as complete mucosal healing of the exposed jaw (n = 24) or as relative healing when surgical therapy downscaled BRONJ II or III to asymptomatic BRONJ stage I (n = 11). Interestingly, perioperative adjuvant treatment or bisphosphonate therapy parameters showed no statistical effect on the treatment outcome. - Conclusions - The results of the present study prove the effectiveness of surgical therapy for BRONJ stage II or III. 
700 1 |a Schaal, Carolin  |d 1989-  |e VerfasserIn  |0 (DE-588)1106284321  |0 (DE-627)86299148X  |0 (DE-576)473988445  |4 aut 
700 1 |a Kargus, Steffen  |d 1984-  |e VerfasserIn  |0 (DE-588)1036761266  |0 (DE-627)751687324  |0 (DE-576)386811970  |4 aut 
700 1 |a Saure, Daniel  |d 1986-  |e VerfasserIn  |0 (DE-588)1016032161  |0 (DE-627)705475662  |0 (DE-576)351440666  |4 aut 
700 1 |a Mertens, Christian  |e VerfasserIn  |0 (DE-588)1091595992  |0 (DE-627)852487223  |0 (DE-576)461744317  |4 aut 
700 1 |a Engel, Michael  |d 1972-  |e VerfasserIn  |0 (DE-588)132967367  |0 (DE-627)52919421X  |0 (DE-576)264912454  |4 aut 
700 1 |a Hoffmann, Jürgen  |d 1965-  |e VerfasserIn  |0 (DE-588)1032524456  |0 (DE-627)738520063  |0 (DE-576)380087189  |4 aut 
700 1 |a Freudlsperger, Christian  |d 1977-  |e VerfasserIn  |0 (DE-588)130275913  |0 (DE-627)589450751  |0 (DE-576)301504105  |4 aut 
773 0 8 |i Enthalten in  |t Oral surgery, oral medicine, oral pathology, oral radiology, and endodontology  |d Orlando, Fla. : Elsevier, 1979  |g 121(2016), 4, Seite 367-372  |h Online-Ressource  |w (DE-627)320415104  |w (DE-600)2001803-4  |w (DE-576)090881028  |x 1528-395X  |7 nnas  |a Surgical management of bisphosphonate-related osteonecrosis of the jaw stages II and III 
773 1 8 |g volume:121  |g year:2016  |g number:4  |g pages:367-372  |g extent:6  |a Surgical management of bisphosphonate-related osteonecrosis of the jaw stages II and III 
856 4 0 |u https://doi.org/10.1016/j.oooo.2015.10.033  |x Verlag  |x Resolving-System  |3 Volltext 
856 4 0 |u http://www.sciencedirect.com/science/article/pii/S2212440315012961  |x Verlag  |3 Volltext 
951 |a AR 
992 |a 20200211 
993 |a Article 
994 |a 2016 
998 |g 130275913  |a Freudlsperger, Christian  |m 130275913:Freudlsperger, Christian  |d 910000  |d 910800  |e 910000PF130275913  |e 910800PF130275913  |k 0/910000/  |k 1/910000/910800/ 
998 |g 1032524456  |a Hoffmann, Jürgen  |m 1032524456:Hoffmann, Jürgen  |d 910000  |d 910800  |e 910000PH1032524456  |e 910800PH1032524456  |k 0/910000/  |k 1/910000/910800/ 
998 |g 132967367  |a Engel, Michael  |m 132967367:Engel, Michael  |d 910000  |d 910800  |e 910000PE132967367  |e 910800PE132967367  |k 0/910000/  |k 1/910000/910800/ 
998 |g 1091595992  |a Mertens, Christian  |m 1091595992:Mertens, Christian  |d 910000  |d 910800  |e 910000PM1091595992  |e 910800PM1091595992  |k 0/910000/  |k 1/910000/910800/ 
998 |g 1016032161  |a Saure, Daniel  |m 1016032161:Saure, Daniel  |d 910000  |d 999701  |e 910000PS1016032161  |e 999701PS1016032161  |k 0/910000/  |k 1/910000/999701/ 
998 |g 1036761266  |a Kargus, Steffen  |m 1036761266:Kargus, Steffen  |d 910000  |d 910800  |e 910000PK1036761266  |e 910800PK1036761266  |k 0/910000/  |k 1/910000/910800/ 
998 |g 1106284321  |a Schaal, Carolin  |m 1106284321:Schaal, Carolin  |d 910000  |d 910800  |e 910000PS1106284321  |e 910800PS1106284321  |k 0/910000/  |k 1/910000/910800/ 
998 |g 130671002  |a Bodem, Jens  |m 130671002:Bodem, Jens  |d 910000  |d 910800  |e 910000PB130671002  |e 910800PB130671002  |k 0/910000/  |k 1/910000/910800/  |p 1  |x j 
999 |a KXP-PPN1689784822  |e 3592812165 
BIB |a Y 
SER |a journal 
JSO |a {"relHost":[{"id":{"issn":["1528-395X"],"eki":["320415104"],"zdb":["2001803-4"]},"origin":[{"dateIssuedDisp":"1979-2011","publisherPlace":"Orlando, Fla. ; St. Louis, Mo.","publisher":"Elsevier ; Mosby","dateIssuedKey":"1979"}],"part":{"text":"121(2016), 4, Seite 367-372","issue":"4","volume":"121","pages":"367-372","year":"2016","extent":"6"},"pubHistory":["79.1995 - 112.2011"],"titleAlt":[{"title":"Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics"}],"title":[{"title":"Oral surgery, oral medicine, oral pathology, oral radiology, and endodontology","title_sort":"Oral surgery, oral medicine, oral pathology, oral radiology, and endodontology"}],"note":["Gesehen am 04.03.24"],"physDesc":[{"extent":"Online-Ressource"}],"recId":"320415104","language":["eng"],"type":{"media":"Online-Ressource","bibl":"periodical"},"disp":"Surgical management of bisphosphonate-related osteonecrosis of the jaw stages II and IIIOral surgery, oral medicine, oral pathology, oral radiology, and endodontology"}],"origin":[{"dateIssuedDisp":"2016","dateIssuedKey":"2016"}],"id":{"eki":["1689784822"],"doi":["10.1016/j.oooo.2015.10.033"]},"person":[{"given":"Jens","family":"Bodem","role":"aut","roleDisplay":"VerfasserIn","display":"Bodem, Jens"},{"display":"Schaal, Carolin","role":"aut","roleDisplay":"VerfasserIn","family":"Schaal","given":"Carolin"},{"given":"Steffen","family":"Kargus","display":"Kargus, Steffen","roleDisplay":"VerfasserIn","role":"aut"},{"family":"Saure","given":"Daniel","display":"Saure, Daniel","role":"aut","roleDisplay":"VerfasserIn"},{"given":"Christian","family":"Mertens","display":"Mertens, Christian","roleDisplay":"VerfasserIn","role":"aut"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Engel, Michael","given":"Michael","family":"Engel"},{"display":"Hoffmann, Jürgen","roleDisplay":"VerfasserIn","role":"aut","given":"Jürgen","family":"Hoffmann"},{"family":"Freudlsperger","given":"Christian","display":"Freudlsperger, Christian","roleDisplay":"VerfasserIn","role":"aut"}],"note":["Available online 1 December 2015","Gesehen am 11.02.2020"],"recId":"1689784822","language":["eng"],"physDesc":[{"extent":"6 S."}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"name":{"displayForm":["Jens Philipp Bodem, MD, DDS, Carolin Schaal, DDS, Steffen Kargus, MD, DDS, Daniel Saure, PhD, Christian Mertens, DDS, Michael Engel, MD, DDS, Jürgen Hoffmann, MD, DDS, and Christian Freudlsperger, MD, DDS"]},"title":[{"title_sort":"Surgical management of bisphosphonate-related osteonecrosis of the jaw stages II and III","title":"Surgical management of bisphosphonate-related osteonecrosis of the jaw stages II and III"}]} 
SRT |a BODEMJENSSSURGICALMA2016 

Similar Items