RIPK1 and death receptor signaling drive biliary damage and early liver tumorigenesis in mice with chronic hepatobiliary injury
Hepatocyte apoptosis is intrinsically linked to chronic liver disease and hepatocarcinogenesis. Conversely, necroptosis of hepatocytes and other liver cell types and its relevance for liver disease is debated. Using liver parenchymal cell (LPC)-specific TGF-beta-activated kinase 1 (TAK1)-deficient (...
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| Main Authors: | , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
15 April 2019
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| In: |
Cell death and differentiation
Year: 2019, Volume: 26, Issue: 12, Pages: 2710-2726 |
| ISSN: | 1476-5403 |
| DOI: | 10.1038/s41418-019-0330-9 |
| Online Access: | Verlag, Volltext: https://doi.org/10.1038/s41418-019-0330-9 Verlag, Volltext: https://www.nature.com/articles/s41418-019-0330-9 |
| Author Notes: | Santosh Krishna-Subramanian, Stephan Singer, Marietta Armaka, Jesus M. Banales, Kerstin Holzer, Peter Schirmacher, Henning Walczak, George Kollias, Manolis Pasparakis, Vangelis Kondylis |
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