RIPK1 and death receptor signaling drive biliary damage and early liver tumorigenesis in mice with chronic hepatobiliary injury

Hepatocyte apoptosis is intrinsically linked to chronic liver disease and hepatocarcinogenesis. Conversely, necroptosis of hepatocytes and other liver cell types and its relevance for liver disease is debated. Using liver parenchymal cell (LPC)-specific TGF-beta-activated kinase 1 (TAK1)-deficient (...

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Bibliographic Details
Main Authors: Subramanian, Santosh Krishna (Author) , Schirmacher, Peter (Author)
Format: Article (Journal)
Language:English
Published: 15 April 2019
In: Cell death and differentiation
Year: 2019, Volume: 26, Issue: 12, Pages: 2710-2726
ISSN:1476-5403
DOI:10.1038/s41418-019-0330-9
Online Access:Verlag, Volltext: https://doi.org/10.1038/s41418-019-0330-9
Verlag, Volltext: https://www.nature.com/articles/s41418-019-0330-9
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Author Notes:Santosh Krishna-Subramanian, Stephan Singer, Marietta Armaka, Jesus M. Banales, Kerstin Holzer, Peter Schirmacher, Henning Walczak, George Kollias, Manolis Pasparakis, Vangelis Kondylis
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