The hepcidin-ferroportin axis controls the iron content of Salmonella-containing vacuoles in macrophages
The effects of iron on vacuole-resident Salmonella in macrophages are unclear. Here the authors show that the bacteria are not subject to nutritional inhibition by iron deprivation, but that iron depletion in the vacuole, via the hepcidin-ferroportin axis, inhibits the bactericidal effect of oxidati...
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
[2018]
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| In: |
Nature Communications
Year: 2018, Volume: 9, Pages: 1-12 |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/s41467-018-04446-8 |
| Online Access: | Verlag, Volltext: https://doi.org/10.1038/s41467-018-04446-8 Verlag, Volltext: https://www.nature.com/articles/s41467-018-04446-8 
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| Author Notes: | Daejin Lim, Kwang Soo Kim, Jae-Ho Jeong, Oriana Marques, Hyun-Ju Kim, Miryoung Song, Tae-Hoon Lee, Jae Il Kim, Hueng-Sik Choi, Jung-Joon Min, Dirk Bumann, Martina U. Muckenthaler & Hyon E. Choy |
| Summary: | The effects of iron on vacuole-resident Salmonella in macrophages are unclear. Here the authors show that the bacteria are not subject to nutritional inhibition by iron deprivation, but that iron depletion in the vacuole, via the hepcidin-ferroportin axis, inhibits the bactericidal effect of oxidative burst. |
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| Item Description: | Gesehen am 20.02.2020 |
| Physical Description: | Online Resource |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/s41467-018-04446-8 |