Atypical teratoid/rhabdoid tumors are comprised of three epigenetic subgroups with distinct enhancer landscapes
Atypical teratoid/rhabdoid tumor (ATRT) is one of the most common brain tumors in infants. Although the prognosis of ATRT patients is poor, some patients respond favorably to current treatments, suggesting molecular inter-tumor heterogeneity. To investigate this further, we genetically and epigeneti...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
February 25, 2016
|
| In: |
Cancer cell
Year: 2016, Volume: 29, Issue: 3, Pages: 379-393 |
| ISSN: | 1878-3686 |
| DOI: | 10.1016/j.ccell.2016.02.001 |
| Online Access: | Verlag, Volltext: https://doi.org/10.1016/j.ccell.2016.02.001 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S1535610816300356 
|
| Author Notes: | Pascal D. Johann, Serap Erkek, Marc Zapatka, Kornelius Kerl, Ivo Buchhalter, Volker Hovestadt, David T. W. Jones, Dominik Sturm, Carl Hermann, Maia Segura Wang, Andrey Korshunov, Marina Rhyzova, Susanne Gröbner, Sebastian Brabetz, Lukas Chavez, Susanne Bens, Stefan Gröschel, Fabian Kratochwil, Andrea Wittmann, Laura Sieber, Christina Geörg, Stefan Wolf, Katja Beck, Florian Oyen, David Capper, Peter van Sluis, Richard Volckmann, Jan Koster, Rogier Versteeg, Andreas von Deimling, Till Milde, Olaf Witt, Andreas E. Kulozik, Martin Ebinger, Tarek Shalaby, Michael Grotzer, David Sumerauer, Josef Zamecnik, Jaume Mora, Nada Jabado, Michael D. Taylor, Annie Huang, Eleonora Aronica, Anna Bertoni, Bernhard Radlwimmer, Torsten Pietsch, Ulrich Schüller, Reinhard Schneppenheim, Paul A. Northcott, Jan O. Korbel, Reiner Siebert, Michael C. Frühwald, Peter Lichter, Roland Eils, Amar Gajjar, Martin Hasselblatt, Stefan M. Pfister, and Marcel Kool |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1690652683 | ||
| 003 | DE-627 | ||
| 005 | 20220817235357.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 200221s2016 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.ccell.2016.02.001 |2 doi | |
| 035 | |a (DE-627)1690652683 | ||
| 035 | |a (DE-599)KXP1690652683 | ||
| 035 | |a (OCoLC)1341307597 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Johann, Pascal-David |d 1985- |e VerfasserIn |0 (DE-588)1017717044 |0 (DE-627)690412339 |0 (DE-576)354193791 |4 aut | |
| 245 | 1 | 0 | |a Atypical teratoid/rhabdoid tumors are comprised of three epigenetic subgroups with distinct enhancer landscapes |c Pascal D. Johann, Serap Erkek, Marc Zapatka, Kornelius Kerl, Ivo Buchhalter, Volker Hovestadt, David T. W. Jones, Dominik Sturm, Carl Hermann, Maia Segura Wang, Andrey Korshunov, Marina Rhyzova, Susanne Gröbner, Sebastian Brabetz, Lukas Chavez, Susanne Bens, Stefan Gröschel, Fabian Kratochwil, Andrea Wittmann, Laura Sieber, Christina Geörg, Stefan Wolf, Katja Beck, Florian Oyen, David Capper, Peter van Sluis, Richard Volckmann, Jan Koster, Rogier Versteeg, Andreas von Deimling, Till Milde, Olaf Witt, Andreas E. Kulozik, Martin Ebinger, Tarek Shalaby, Michael Grotzer, David Sumerauer, Josef Zamecnik, Jaume Mora, Nada Jabado, Michael D. Taylor, Annie Huang, Eleonora Aronica, Anna Bertoni, Bernhard Radlwimmer, Torsten Pietsch, Ulrich Schüller, Reinhard Schneppenheim, Paul A. Northcott, Jan O. Korbel, Reiner Siebert, Michael C. Frühwald, Peter Lichter, Roland Eils, Amar Gajjar, Martin Hasselblatt, Stefan M. Pfister, and Marcel Kool |
| 264 | 1 | |c February 25, 2016 | |
| 300 | |a 15 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 21.02.2020 | ||
| 520 | |a Atypical teratoid/rhabdoid tumor (ATRT) is one of the most common brain tumors in infants. Although the prognosis of ATRT patients is poor, some patients respond favorably to current treatments, suggesting molecular inter-tumor heterogeneity. To investigate this further, we genetically and epigenetically analyzed 192 ATRTs. Three distinct molecular subgroups of ATRTs, associated with differences in demographics, tumor location, and type of SMARCB1 alterations, were identified. Whole-genome DNA and RNA sequencing found no recurrent mutations in addition to SMARCB1 that would explain the differences between subgroups. Whole-genome bisulfite sequencing and H3K27Ac chromatin-immunoprecipitation sequencing of primary tumors, however, revealed clear differences, leading to the identification of subgroup-specific regulatory networks and potential therapeutic targets. | ||
| 700 | 1 | |a Sturm, Dominik |d 1983- |e VerfasserIn |0 (DE-588)1035550709 |0 (DE-627)749549165 |0 (DE-576)383282144 |4 aut | |
| 700 | 1 | |a Korshunov, Andrey |e VerfasserIn |0 (DE-588)1043235361 |0 (DE-627)770439365 |0 (DE-576)394592093 |4 aut | |
| 700 | 1 | |a Gröschel, Stefan |d 1979- |e VerfasserIn |0 (DE-588)138335664 |0 (DE-627)601621565 |0 (DE-576)307122352 |4 aut | |
| 700 | 1 | |a Geörg, Christina |d 1981- |e VerfasserIn |0 (DE-588)1017957827 |0 (DE-627)690472315 |0 (DE-576)354690892 |4 aut | |
| 700 | 1 | |a Capper, David |d 1979- |e VerfasserIn |0 (DE-588)133950751 |0 (DE-627)558829902 |0 (DE-576)300212402 |4 aut | |
| 700 | 1 | |a Deimling, Andreas von |d 1959- |e VerfasserIn |0 (DE-588)103034115X |0 (DE-627)735093946 |0 (DE-576)378138065 |4 aut | |
| 700 | 1 | |a Milde, Till |d 1973- |e VerfasserIn |0 (DE-588)1038311837 |0 (DE-627)75711234X |0 (DE-576)39229334X |4 aut | |
| 700 | 1 | |a Witt, Olaf |d 1965- |e VerfasserIn |0 (DE-588)17275030X |0 (DE-627)697681750 |0 (DE-576)133607410 |4 aut | |
| 700 | 1 | |a Kulozik, Andreas |d 1959- |e VerfasserIn |0 (DE-588)1025736567 |0 (DE-627)723892032 |0 (DE-576)167091638 |4 aut | |
| 700 | 1 | |a Pfister, Stefan |d 1974- |e VerfasserIn |0 (DE-588)123850215 |0 (DE-627)706450930 |0 (DE-576)293908400 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Cancer cell |d Cambridge, Mass. : Cell Press, 2002 |g 29(2016), 3, Seite 379-393 |h Online-Ressource |w (DE-627)343970082 |w (DE-600)2074034-7 |w (DE-576)097935972 |x 1878-3686 |7 nnas |a Atypical teratoid/rhabdoid tumors are comprised of three epigenetic subgroups with distinct enhancer landscapes |
| 773 | 1 | 8 | |g volume:29 |g year:2016 |g number:3 |g pages:379-393 |g extent:15 |a Atypical teratoid/rhabdoid tumors are comprised of three epigenetic subgroups with distinct enhancer landscapes |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.ccell.2016.02.001 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u http://www.sciencedirect.com/science/article/pii/S1535610816300356 |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20200221 | ||
| 993 | |a Article | ||
| 994 | |a 2016 | ||
| 998 | |g 123850215 |a Pfister, Stefan |m 123850215:Pfister, Stefan |d 910000 |d 910500 |e 910000PP123850215 |e 910500PP123850215 |k 0/910000/ |k 1/910000/910500/ | ||
| 998 | |g 1025736567 |a Kulozik, Andreas |m 1025736567:Kulozik, Andreas |d 910000 |d 910500 |e 910000PK1025736567 |e 910500PK1025736567 |k 0/910000/ |k 1/910000/910500/ |p 32 | ||
| 998 | |g 1038311837 |a Milde, Till |m 1038311837:Milde, Till |d 910000 |d 910500 |e 910000PM1038311837 |e 910500PM1038311837 |k 0/910000/ |k 1/910000/910500/ | ||
| 998 | |g 103034115X |a Deimling, Andreas von |m 103034115X:Deimling, Andreas von |d 910000 |d 912000 |e 910000PD103034115X |e 912000PD103034115X |k 0/910000/ |k 1/910000/912000/ | ||
| 998 | |g 133950751 |a Capper, David |m 133950751:Capper, David |d 910000 |e 910000PC133950751 |k 0/910000/ | ||
| 998 | |g 1017957827 |a Geörg, Christina |m 1017957827:Geörg, Christina |d 910000 |e 910000PG1017957827 |k 0/910000/ | ||
| 998 | |g 138335664 |a Gröschel, Stefan |m 138335664:Gröschel, Stefan |d 910000 |e 910000PG138335664 |k 0/910000/ | ||
| 998 | |g 1043235361 |a Korshunov, Andrey |m 1043235361:Korshunov, Andrey |d 910000 |e 910000PK1043235361 |k 0/910000/ | ||
| 998 | |g 1035550709 |a Sturm, Dominik |m 1035550709:Sturm, Dominik |d 910000 |d 910500 |e 910000PS1035550709 |e 910500PS1035550709 |k 0/910000/ |k 1/910000/910500/ | ||
| 998 | |g 1017717044 |a Johann, Pascal-David |m 1017717044:Johann, Pascal-David |d 910000 |d 910500 |e 910000PJ1017717044 |e 910500PJ1017717044 |k 0/910000/ |k 1/910000/910500/ |p 1 |x j | ||
| 999 | |a KXP-PPN1690652683 |e 359738448X | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"origin":[{"dateIssuedDisp":"February 25, 2016","dateIssuedKey":"2016"}],"name":{"displayForm":["Pascal D. Johann, Serap Erkek, Marc Zapatka, Kornelius Kerl, Ivo Buchhalter, Volker Hovestadt, David T. W. Jones, Dominik Sturm, Carl Hermann, Maia Segura Wang, Andrey Korshunov, Marina Rhyzova, Susanne Gröbner, Sebastian Brabetz, Lukas Chavez, Susanne Bens, Stefan Gröschel, Fabian Kratochwil, Andrea Wittmann, Laura Sieber, Christina Geörg, Stefan Wolf, Katja Beck, Florian Oyen, David Capper, Peter van Sluis, Richard Volckmann, Jan Koster, Rogier Versteeg, Andreas von Deimling, Till Milde, Olaf Witt, Andreas E. Kulozik, Martin Ebinger, Tarek Shalaby, Michael Grotzer, David Sumerauer, Josef Zamecnik, Jaume Mora, Nada Jabado, Michael D. Taylor, Annie Huang, Eleonora Aronica, Anna Bertoni, Bernhard Radlwimmer, Torsten Pietsch, Ulrich Schüller, Reinhard Schneppenheim, Paul A. Northcott, Jan O. Korbel, Reiner Siebert, Michael C. Frühwald, Peter Lichter, Roland Eils, Amar Gajjar, Martin Hasselblatt, Stefan M. Pfister, and Marcel Kool"]},"type":{"media":"Online-Ressource","bibl":"article-journal"},"id":{"eki":["1690652683"],"doi":["10.1016/j.ccell.2016.02.001"]},"recId":"1690652683","person":[{"given":"Pascal-David","role":"aut","family":"Johann","display":"Johann, Pascal-David"},{"display":"Sturm, Dominik","role":"aut","family":"Sturm","given":"Dominik"},{"display":"Korshunov, Andrey","role":"aut","family":"Korshunov","given":"Andrey"},{"display":"Gröschel, Stefan","family":"Gröschel","role":"aut","given":"Stefan"},{"given":"Christina","role":"aut","family":"Geörg","display":"Geörg, Christina"},{"given":"David","family":"Capper","role":"aut","display":"Capper, David"},{"family":"Deimling","role":"aut","display":"Deimling, Andreas von","given":"Andreas von"},{"given":"Till","family":"Milde","role":"aut","display":"Milde, Till"},{"role":"aut","family":"Witt","display":"Witt, Olaf","given":"Olaf"},{"given":"Andreas","display":"Kulozik, Andreas","role":"aut","family":"Kulozik"},{"given":"Stefan","display":"Pfister, Stefan","family":"Pfister","role":"aut"}],"language":["eng"],"note":["Gesehen am 21.02.2020"],"title":[{"title_sort":"Atypical teratoid/rhabdoid tumors are comprised of three epigenetic subgroups with distinct enhancer landscapes","title":"Atypical teratoid/rhabdoid tumors are comprised of three epigenetic subgroups with distinct enhancer landscapes"}],"physDesc":[{"extent":"15 S."}],"relHost":[{"part":{"year":"2016","pages":"379-393","issue":"3","extent":"15","text":"29(2016), 3, Seite 379-393","volume":"29"},"physDesc":[{"extent":"Online-Ressource"}],"title":[{"title":"Cancer cell","title_sort":"Cancer cell"}],"disp":"Atypical teratoid/rhabdoid tumors are comprised of three epigenetic subgroups with distinct enhancer landscapesCancer cell","origin":[{"publisher":"Cell Press ; Elsevier","dateIssuedDisp":"2002-","publisherPlace":"Cambridge, Mass. ; New York, NY","dateIssuedKey":"2002"}],"id":{"issn":["1878-3686"],"zdb":["2074034-7"],"eki":["343970082"]},"recId":"343970082","type":{"bibl":"periodical","media":"Online-Ressource"},"pubHistory":["1.2002 -"],"note":["Gesehen am 28.02.11"],"language":["eng"]}]} | ||
| SRT | |a JOHANNPASCATYPICALTE2520 | ||